Novel and Selective TLR7 Antagonists among the Imidazo[1,2-a]pyrazines, Imidazo[1,5-a]quinoxalines, and Pyrazolo[1,5-a]quinoxalines Series

Autor: Carine Deleuze-Masquéfa, Soulaima Chamat, Issam Kassab, Nour Bou Karroum, Pierre-Antoine Bonnet, Cindy Patinote, Mona Diab-Assaf, Hasnaa Bouharoun-Tayoun, Jean-François Guichou, Pierre Cuq, Georges Moarbess

Publikováno v: Journal of Medicinal Chemistry. 62:7015-7031

The Toll-like receptors (TLRs) 7 and 8 play an important role in the immune system activation, and their agonists may therefore serve as promising candidate vaccine adjuvants. However, the chronic immune activation by excessive TLR stimulation is a h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f287a1be945fb10181dddf0365af346
https://doi.org/10.1021/acs.jmedchem.9b00411

Preparation, characterization, and hydrogenation activity of new Rh 0 –MCM-41 catalysts prepared from as-synthesized MCM-41 and RhCl 3

Autor: Georges Moarbess, Franck Launay, Maya Boutros, Thomas Onfroy

Publikováno v: Comptes Rendus Chimie. 21:514-522

Impregnation of as-synthesized MCM-41 silica by ethanolic solutions of rhodium(III) chloride was tested as an alternative to its introduction into the synthesis gel to get, after calcination and reduction by H2, highly dispersed metal(0) nanoparticle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01163f7f485e0ad5e7a088260cb1c5c3
https://doi.org/10.1016/j.crci.2018.01.003

Novel and Selective TLR7 Antagonists among the Imidazo[1,2

Autor: Nour, Bou Karroum, Georges, Moarbess, Jean-François, Guichou, Pierre-Antoine, Bonnet, Cindy, Patinote, Hasnaa, Bouharoun-Tayoun, Soulaima, Chamat, Pierre, Cuq, Mona, Diab-Assaf, Issam, Kassab, Carine, Deleuze-Masquefa

Publikováno v: Journal of medicinal chemistry. 62(15)

The Toll-like receptors (TLRs) 7 and 8 play an important role in the immune system activation, and their agonists may therefore serve as promising candidate vaccine adjuvants. However, the chronic immune activation by excessive TLR stimulation is a h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e559df105f35a4f1969d967f25b02d09
https://pubmed.ncbi.nlm.nih.gov/31283223

Imidazo[1,2-a]pyrazine, Imidazo[1,5-a]quinoxaline and Pyrazolo[1,5-a]quinoxaline derivatives as IKK1 and IKK2 inhibitors

Autor: Kamel Hadj-Kaddour, Issam Kassab, Cindy Patinote, Nour Bou Karroum, Pierre-Antoine Bonnet, Georges Moarbess, Pierre Cuq, Carine Deleuze-Masquéfa, Mona Diab-Assaf

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2017, 138, pp.909-919. ⟨10.1016/j.ejmech.2017.07.021⟩

International audience; The transcription nuclear factor NF-κB plays a pivotal role in chronic and acute inflammatory diseases. Among the several and diverse strategies for inhibiting NF-κB, one of the most effective approach considered by the phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bc0f9ba5eb9f6ab228d32e37f6b83a
https://pubmed.ncbi.nlm.nih.gov/28750313

Pharmacokinetic properties and metabolism of a new potent antimalarial N-alkylamidine compound, M64, and its corresponding bioprecursors

Autor: Françoise Bressolle, Olivier Berger, Florence Gattacceca, Georges Moarbess, Sharon Wein, Samuel Le Pape, Christophe Tran Van Ba, Delphine Margout, Roger Escale, Henri Vial

Publikováno v: European Journal of Pharmaceutical Sciences
European Journal of Pharmaceutical Sciences, Elsevier, 2011, 42, pp.81-90. ⟨10.1016/j.ejps.2010.10.012⟩

International audience; Antimalarial activities and pharmacokinetics of the bis-alkylamidine, M64, and its amidoxime, M64-AH, and O-methylsulfonate, M64-S-Me, derivatives were investigated. M64 and M64-S-Me had the most potent activity against the Pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a48961aba7bfe373121b0514c8123b
https://hal.archives-ouvertes.fr/hal-00570553