Divergent estimates of the ratio between Na+-Ca2+ current densities in t-tubular and surface membranes of rat ventricular cardiomyocytes

Autor: Jiří Šimurda, Georges Christé, Michal Pásek, Markéta Bébarová

Publikováno v: Journal of Cell Science. 134

The ratio between Na+-Ca2+ exchange current densities in t-tubular and surface membranes of rat ventricular cardiomyocytes (JNaCa-ratio) estimated from electrophysiological data published to date yields strikingly different values between 1.7 and nea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5e03d761c2ba21271fd114245bbbbb
https://doi.org/10.1242/jcs.258228

Accounting for cardiac t-tubule increase with age and myocyte volume to improve measurements of its membrane area and ionic current densities

Autor: Georges Christé, C. Chouabe, Robert Bonvallet

Publikováno v: Progress in Biophysics and Molecular Biology
Progress in Biophysics and Molecular Biology, 2020, 157, pp.40-53. ⟨10.1016/j.pbiomolbio.2020.06.005⟩
Progress in Biophysics and Molecular Biology, Elsevier, 2020, 157, pp.40-53. ⟨10.1016/j.pbiomolbio.2020.06.005⟩

International audience; In-silico models of cardiac myocytes allow simulating experiments in numbers on series of myocytes as well as on large populations of myocytes assembled in 3D structures. The simulated myocyte populations should have realistic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dea80082a7aa01c9679043a698d366
https://hal.inrae.fr/hal-03152615/document

The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT

Autor: Gilles Millat, Marek Jastrzebski, Mohamed Chahine, Yohann Vincent, Eckhard Ficker, Hugo Poulin, Asma Mechakra, Philippe Chevalier, Georges Christé, Valérie Pouliot

Publikováno v: Gene. 536:348-356

A variant of the ether-à-go-go related channel (hERG), p.Arg148Trp (R148W) was found at heterozygous state in two infants who died from sudden infant death syndrome (SIDS), one with documented prolonged QTc and Torsade de Pointes (TdP), and in an ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ac0a12dcec2b2c5182c37349686bca
https://doi.org/10.1016/j.gene.2013.11.072

In utero onset of long QT syndrome with atrioventricular block and spontaneous or lidocaine-induced ventricular tachycardia: Compound effects of hERG pore region mutation and SCN5A N-terminus variant

Autor: Shuenn-Nan Chiu, Olivier Thériault, Chien Chih Chang, Hai Huang, Mei-Hwan Wu, Ming-Tai Lin, Eckhard Ficker, Mohamed Chahine, Georges Christé

Publikováno v: Heart Rhythm. 5:1567-1574

Background Mexiletine may protect patients with long QT syndrome (LQTS) type 3 from arrhythmias. However, we found an unusual in utero presentation of intermittent atrioventricular block and ventricular tachycardia (spontaneous or lidocaine-induced)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9b3f8f3d118013f23938326a53dc5e
https://doi.org/10.1016/j.hrthm.2008.08.010

Acute effects of ethanol on action potential and intracellular Ca(2+) transient in cardiac ventricular cells: a simulation study

Autor: Jiří Šimurda, Georges Christé, Michal Pásek, Markéta Bébarová, Milena Šimurdová

Publikováno v: Medicalbiological engineeringcomputing. 54(5)

Alcohol consumption may result in electrocardiographic changes and arrhythmias, at least partly due to effects of ethanol on cardiac ionic currents. Contractility and intracellular Ca2+ dynamics seem to be altered as well. In this study, we integrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c96da0578f28f5ac4cc0d082f2a8b6
https://pubmed.ncbi.nlm.nih.gov/26280513