Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Georges, Abboud"'
Autor:
Ahmed S. Elshikha, Yong Ge, Josephine Brown, Nathalie Kanda, Mojgan Zadeh, Georges Abboud, Seung-Chul Choi, Gregg Silverman, Timothy J. Garrett, William L. Clapp, Mansour Mohamadzadeh, Laurence Morel
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107122- (2023)
Summary: Gut dysbiosis has been associated with lupus pathogenesis, and fecal microbiota transfers (FMT) from lupus-prone mice shown to induce autoimmune activation into healthy mice. The immune cells of lupus patients exhibit an increased glucose me
Externí odkaz:
https://doaj.org/article/229a7a042b954b65b4b97ba2cac53849
Autor:
Laurence Morel, Seung-Chul Choi, Josephine Brown, Georges Abboud, Ahmed S Elshikha, Yong Ge, Nathalie Kanda, Timothy J Garrett, William Clapp, Mansour Zadeh
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/96f9123f909046638b896a1f03eb17cb
Autor:
Ahmed S. Elshikha, Xiang Yu Teng, Nathalie Kanda, Wei Li, Seung-Chul Choi, Georges Abboud, Morgan Terrell, Kristianna Fredenburg, Laurence Morel
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
We report a novel model of lupus-associated cardiovascular pathology accelerated by the TLR7 agonist R848 in lupus-prone B6.Sle1.Sle2.Sle3 (TC) mice. R848-treated TC mice but not non-autoimmune C57BL/6 (B6) controls developed microvascular inflammati
Externí odkaz:
https://doaj.org/article/7b50c7a510614092856dbcfa17b01bd2
Autor:
Josephine Brown, Georges Abboud, Longhuan Ma, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Jean Lee, Weidan Peng, Joy Cagmat, Tamas Faludi, Mansour Mohamadzadeh, Timothy Garrett, Laura Mandik-Nayak, Alexander Chervonsky, Andras Perl, Laurence Morel
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104241- (2022)
Summary: A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell activation. Metabolomic analyses dem
Externí odkaz:
https://doaj.org/article/d23480af288b4f76bbaf7d930d6da554
Publikováno v:
BMC Immunology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Systemic lupus erythematosus is an autoimmune disease characterized by an overproduction of autoantibodies resulting from dysregulation in multiple immune cell types. D-mannose is a C− 2 epimer of glucose that exhibits immunoreg
Externí odkaz:
https://doaj.org/article/90495eb6874443128fef1d4e747265e3
Autor:
Ahmed Samir Elshikha, Ye Yuan, Yuanqing Lu, Mong-Jen Chen, Georges Abboud, Mohammad Ahsanul Akbar, Henrike Plate, Hedwig Wolney, Tanja Hoffmann, Eleni Tagari, Leilani Zeumer, Laurence Morel, Sihong Song
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss , Pp 131-142 (2018)
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by high levels of pathogenic autoantibodies and tissue damage. Multiple studies showed that dendritic cell (DC) activation plays a critical role in SLE pathogenesi
Externí odkaz:
https://doaj.org/article/e575778530f141d29aa43f3805e56eb0
Autor:
Seung-Chul Choi, Anton A. Titov, Georges Abboud, Howard R. Seay, Todd M. Brusko, Derry C. Roopenian, Shahram Salek-Ardakani, Laurence Morel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
T cell functions depend on distinct metabolic fluxes. Here the authors show different metabolic requirements of humoral responses to self versus microbial antigens: while glucose is dispensable for antiviral Tfh and antibody responses, it is essentia
Externí odkaz:
https://doaj.org/article/3e0a1f8d30674ceda6619fa064e835de
Autor:
Georges Abboud
Publikováno v:
Revista de Direito da Faculdade Guanambi, Vol 2, Iss 01, Pp 62-69 (2016)
Trata-se de artigo cuja finalidade é exclusivamente comparativa. O escopo é demonstrar que não devemos confundir o sistema de provimentos vinculantes do CPC-2015 com o sistema genuíno de precedentes do direito inglês. Essa diferenciação busca
Externí odkaz:
https://doaj.org/article/804fa90bb0744e49a51905ab14f158c6
Publikováno v:
J Immunol
BATF3-deficient mice that lack CD8+ dendritic cells (DCs) showed an exacerbation of chronic graft-versus-host disease (cGVHD), including T follicular helper (Tfh) cell and autoantibody responses, whereas mice carrying the Sle2c2 lupus-suppressive loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585774e8b7e58e8bf0af60a8819062d1
https://doi.org/10.4049/jimmunol.2100242
https://doi.org/10.4049/jimmunol.2100242
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to xanthosine monophosphate, the rate-limiting step in de novo guanosine monophosphate (GMP) synthesis. In cultured cells, IMPDH polymerizes into micron-scale filamentous str
Externí odkaz:
https://doaj.org/article/30a62799ed5e4030a1f42ce20ca3c6ad