Zobrazeno 1 - 5
of 5
pro vyhledávání: '"George Zakusilo"'
Autor:
Michael R. Murphy, Anthony Ramadei, Ahmet Doymaz, Sophia Varriano, Devorah Natelson, Amy Yu, Sera Aktas, Marie Mazzeo, Michael Mazzeo, George Zakusilo, Frida E. Kleiman
Publikováno v:
bioRxiv
Alternative Polyadenylation (APA) is an emerging mechanism for dynamic changes in gene expression. Previously, we described widespread APA occurrence in introns during the DNA damage response (DDR). Here, we show that a DNA damage activated APA event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4be44e9b54e2df77fcc587b077e321b
https://europepmc.org/articles/PMC9882041/
https://europepmc.org/articles/PMC9882041/
Autor:
Logan R. Myler, Charles G Kinzig, Titia de Lange, George Zakusilo, Sarah W Cai, Nanda Kumar Sasi
Publikováno v:
Genes Dev
The mammalian telomeric shelterin complex—comprised of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1—blocks the DNA damage response at chromosome ends and interacts with telomerase and the CST complex to regulate telomere length. The evolutionary origin
SummaryThe maintenance of genome integrity requires that telomerase action be limited to telomeres and not convert DSBs into neotelomeres. Using the breakpoint sequence from an apparent germline neotelomere formation event, we developed an assay to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7da4253b7f07b18ba29021463983504a
https://doi.org/10.1101/2022.10.31.514589
https://doi.org/10.1101/2022.10.31.514589
Autor:
Xiaohan Ying, Matthew S Lee, Justin J Choi, Keith Mages, Caroline Jedlicka, Yu Han Chen, Hyejin Kim, Julie Kim, George Zakusilo, Andrew Zhu
Publikováno v:
Infection
Background Laboratory parameters and the associated clinical outcomes have been an area of focus in COVID-19 research globally. Purpose We performed a scoping review to synthesize laboratory values described in the literature and their associations w
Autor:
Jorge Baquero, Michael R. Murphy, Bin Tian, Emral Devany, Xiaokan Zhang, Mainul Hoque, George Zakusilo, Frida E. Kleiman, Ji Yeon Park
Publikováno v:
Cell Discovery
The DNA damage response involves coordinated control of gene expression and DNA repair. Using deep sequencing, we found widespread changes of alternative cleavage and polyadenylation site usage on ultraviolet-treatment in mammalian cells. Alternative