Immune‐mediated ECM depletion improves tumour perfusion and payload delivery

Autor: Yen Ling Yeow, Venkata Ramana Kotamraju, Xiao Wang, Meenu Chopra, Nasibah Azme, Jiansha Wu, Tobias D Schoep, Derek S Delaney, Kirk Feindel, Ji Li, Kelsey M Kennedy, Wes M Allen, Brendan F Kennedy, Irma Larma, David D Sampson, Lisa M Mahakian, Brett Z Fite, Hua Zhang, Tomas Friman, Aman P Mann, Farah A Aziz, M Priyanthi Kumarasinghe, Mikael Johansson, Hooi C Ee, George Yeoh, Lingjun Mou, Katherine W Ferrara, Hector Billiran, Ruth Ganss, Erkki Ruoslahti, Juliana Hamzah

Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-20 (2019)

Abstract High extracellular matrix (ECM) content in solid cancers impairs tumour perfusion and thus access of imaging and therapeutic agents. We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds. We tar

Externí odkaz: https://doaj.org/article/2e2437d4c1094f77b0d61ca7df6fa756

Human Amnion Epithelial Cell Therapy for Chronic Liver Disease

Autor: Neil Andrewartha, George Yeoh

Publikováno v: Stem Cells International, Vol 2019 (2019)

Liver fibrosis is a common consequence of chronic liver disease. Over time, liver fibrosis can develop into liver cirrhosis. Current therapies for liver fibrosis are limited, and liver transplant is the only curative therapy for patients who progress

Externí odkaz: https://doaj.org/article/b799d24508ef47a183718c75a99a8587

Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential

Autor: Rodrigo Carlessi, Elena Denisenko, Ebru Boslem, Julia Köhn-Gaone, Nathan Main, N. Dianah B. Abu Bakar, Gayatri D. Shirolkar, Matthew Jones, Aaron B. Beasley, Daniel Poppe, Benjamin J. Dwyer, Connie Jackaman, M. Christian Tjiam, Ryan Lister, Michael Karin, Jonathan A. Fallowfield, Timothy J. Kendall, Stuart J. Forbes, Elin S. Gray, John K. Olynyk, George Yeoh, Alistair R.R. Forrest, Grant A. Ramm, Mark A. Febbraio, Janina E.E. Tirnitz-Parker

Publikováno v: Carlessi, R, Denisenko, E, Boslem, E, Köhn-Gaone, J, Main, N, Abu bakar, N D B, Shirolkar, G D, Jones, M, Beasley, A B, Poppe, D, Dwyer, B J, Jackaman, C, Tjiam, M C, Lister, R, Karin, M, Fallowfield, J A, Kendall, T J, Forbes, S J, Gray, E S, Olynyk, J K, Yeoh, G, Forrest, A R R, Ramm, G A, Febbraio, M A & Tirnitz-Parker, J E E 2023, ' Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential ', Cell Genomics, pp. 100301 . https://doi.org/10.1016/j.xgen.2023.100301

Current approaches to stage chronic liver diseases have limited utility to predict liver cancer risk. Here, we employed single nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and pre-malignant livers using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79b1e0fbed62d67780b4f1bbfca2265
https://doi.org/10.1016/j.xgen.2023.100301

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Autor: Ary Marsee, Floris J.M. Roos, Monique M.A. Verstegen, Helmuth Gehart, Eelco de Koning, Frédéric Lemaigre, Stuart J. Forbes, Weng Chuan Peng, Meritxell Huch, Takanori Takebe, Ludovic Vallier, Hans Clevers, Luc J.W. van der Laan, Bart Spee, Floris Roos, Monique Verstegen, Stuart Forbes, Luc van der Laan, Sylvia Boj, Pedro Baptista, Kerstin Schneeberger, Carol Soroka, Markus Heim, Sandro Nuciforo, Kenneth Zaret, Yoshimasa Saito, Matthias Lutolf, Vincenzo Cardinale, Ben Simons, Sven van IJzendoorn, Akihide Kamiya, Hiromi Chikada, Shuyong Wang, Seon Ju Mun, Myung Jin Son, Tamer Tevfik Onder, James Boyer, Toshiro Sato, Nikitas Georgakopoulos, Andre Meneses, Laura Broutier, Luke Boulter, Dominic Grün, Jan IJzermans, Benedetta Artegiani, Ruben van Boxtel, Ewart Kuijk, Guido Carpino, Gary Peltz, Jesus Banales, Nancy Man, Luigi Aloia, Nicholas LaRusso, Gregory George, Casey Rimland, George Yeoh, Anne Grappin-Botton, Daniel Stange, Nicole Prior, Janina E.E. Tirnitz-Parker, Emma Andersson, Chiara Braconi, Nicholas Hannan, Wei-Yu Lu, Stephen Strom, Pau Sancho-Bru, Shinichiro Ogawa, Vincenzo Corbo, Madeline Lancaster, Huili Hu, Sabine Fuchs, Delilah Hendriks

Publikováno v: Cell Stem Cell
Cell Stem Cell, 28(5), 816-832. Cell Press
Cell Stem Cell, Vol. 28, no. 5, p. 816-832 (2021)
Cell Stem Cell, 28(5), 816-832. CELL PRESS
Cell Stem Cell, 28(5), 816. Cell Press

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2ad5dde6f10e8b90de604b88f3f1ff

Human Liver Progenitor Cell Lines Are Readily Established From Non-Tumorous Tissue Adjacent to Hepatocellular Carcinoma.

Autor: Aibin Zhang, Roslyn London, Frederik Michael Schulz, Philippe Wilfred Roger Giguère-Simmonds, Luc Delriviere, Harsha Chandraratana, Kathy Hardy, Shusen Zheng, John K. Olynyk, George Yeoh

Publikováno v: Stem Cells & Development; Aug2010, Vol. 19 Issue 8, p1277-1284, 8p