Increased Vulnerability to Atrial Fibrillation Is Associated With Increased Susceptibility to Alternans in Old Sheep

Autor: Charles M. Pearman, George W.P. Madders, Emma J. Radcliffe, Graeme J. Kirkwood, Michael Lawless, Amy Watkins, Charlotte E.R. Smith, Andrew W. Trafford, David A. Eisner, Katharine M. Dibb

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 23 (2018)

Background Atrial fibrillation (AF) is common in the elderly, but rare in the young; however, the changes that occur with age that promote AF are not fully understood. Action potential (AP) alternans may be involved in the initiation of AF. Using a t

Externí odkaz: https://doaj.org/article/f7e1341037234cee820cd751d17b30eb

Optimising Large Animal Models of Sustained Atrial Fibrillation: Relevance of the Critical Mass Hypothesis

Autor: Katharine M. Dibb, George W.P. Madders, Andrew W. Trafford, Charlotte E.R. Smith, Nathan Denham, Charles M. Pearman

Publikováno v: Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Denham, N, Pearman, C, Madders, G, Smith, C E R, Trafford, A & Dibb, K 2021, ' Optimising Large Animal Models of Sustained Atrial Fibrillation: Relevance of the Critical Mass Hypothesis ', Frontiers in Physiology . https://doi.org/10.3389/fphys.2021.690897

BackgroundLarge animal models play an important role in our understanding of the pathophysiology of atrial fibrillation (AF). Our aim was to determine whether prospectively collected baseline variables could predict the development of sustained AF in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0768f2b78eb062ba547f19cf2a2d241
https://www.frontiersin.org/articles/10.3389/fphys.2021.690897/full

Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure

Autor: Jessica L. Caldwell, Nathan Denham, George W.P. Madders, Charles M. Pearman, Katharine M. Dibb, David A. Eisner, Andrew W. Trafford

Publikováno v: Denham, N C, Pearman, C M, Caldwell, J L, Madders, G W P, Eisner, D A, Trafford, A W & Dibb, K M 2018, ' Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure ', Frontiers in Physiology, vol. 9, no. OCT, 1380, pp. 1380 . https://doi.org/10.3389/fphys.2018.01380
Frontiers in Physiology
Frontiers in Physiology, Vol 9 (2018)

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship exists between the two - AF exacerbates heart failure causing a significant increase in heart failure symptoms, admissions to hospital and cardiovascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29a12e62fec5aaeeaa326da1c0fa57e
https://www.research.manchester.ac.uk/portal/en/publications/calcium-in-the-pathophysiology-of-atrial-fibrillation-and-heart-failure(2822052e-7ffe-4c27-8cb6-e7bdc79aa172).html

Phosphodiesterase-5 inhibition with sildenafil suppresses triggered ventricular arrhythmias and calcium waves via reduced sarcoplasmic reticulum content in the large mammal

Autor: George W.P. Madders, David Hutchings, Andrew W. Trafford, Katharine M. Dibb, Charles M. Pearman, Lori Woods, David A. Eisner

Publikováno v: Journal of Molecular and Cellular Cardiology. 120:37

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71fc6bdaf6ae45d8c4fc528a6c91225c
https://doi.org/10.1016/j.yjmcc.2018.05.112

179 Phosphodiesterase-5 inhibition with sildenafil suppresses calcium waves by reducing sarcoplasmic reticulum content

Autor: David Hutchings, George W.P. Madders, Katharine M. Dibb, Andrew W. Trafford, David A. Eisner, Lori Woods, Charles M. Pearman

Publikováno v: Heart. 103:A124.1-A124

Rationale: Occurrence of diastolic Ca2+ waves in cardiac myocytes leads to arrhythmias by inducing delayed after-depolarisations. Waves are initiated when sarcoplasmic reticulum (SR) content reaches a critical threshold level. The phosphodiesterase-5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66a9979406a957c67b533995f7e45e93
https://doi.org/10.1136/heartjnl-2017-311726.177