Zobrazeno 1 - 10
of 117
pro vyhledávání: '"George W. Rogers"'
Autor:
Brandon R. Desousa, Kristen K.O. Kim, Anthony E. Jones, Andréa B. Ball, Wei Y. Hsieh, Pamela Swain, Danielle H. Morrow, Alexandra J. Brownstein, David A. Ferrick, Orian S. Shirihai, Andrew Neilson, David A. Nathanson, George W. Rogers, Brian P. Dranka, Anne N. Murphy, Charles Affourtit, Steven J. Bensinger, Linsey Stiles, Natalia Romero, Ajit S. Divakaruni
Oxidative phosphorylation and glycolysis are the dominant ATP-generating pathways in mammalian metabolism. The balance between these two pathways is often shifted to execute cell-specific functions in response to stimuli that promote activation, prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262cd739bb8f66589fce51566c8ae045
https://doi.org/10.1101/2022.04.16.488523
https://doi.org/10.1101/2022.04.16.488523
Autor:
George W Rogers, Martin D Brand, Susanna Petrosyan, Deepthi Ashok, Alvaro A Elorza, David A Ferrick, Anne N Murphy
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21746 (2011)
Recently developed technologies have enabled multi-well measurement of O(2) consumption, facilitating the rate of mitochondrial research, particularly regarding the mechanism of action of drugs and proteins that modulate metabolism. Among these techn
Externí odkaz:
https://doaj.org/article/6809df3e6d854ea0b649391d3f2dff26
Autor:
James L. Figarola, Sanjay Awasthi, Arthur D. Riggs, David A. Horne, George W. Rogers, Joshua D. Tompkins, Jyotsana Singhal, Charles Warden, Sharad S. Singhal
Publikováno v:
Journal of Biological Chemistry. 290:30321-30341
Mitochondrial oxidative phosphorylation produces most of the energy in aerobic cells by coupling respiration to the production of ATP. Mitochondrial uncouplers, which reduce the proton gradient across the mitochondrial inner membrane, create a futile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08c58890b6473cd357c515e8e0977ae
https://doi.org/10.1074/jbc.m115.686352
https://doi.org/10.1074/jbc.m115.686352
Publikováno v:
The Journal of Immunology. 204:73.2-73.2
Tyrosine kinase inhibitors have been actively investigated as potential therapies for various cancers including blood tumors. However, as T cell activation can also be mediated by various tyrosine kinases, relevant inhibitors are also now being consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8c961c66455113cd1b5937936d08fce
https://doi.org/10.4049/jimmunol.204.supp.73.2
https://doi.org/10.4049/jimmunol.204.supp.73.2
Autor:
Linsey Stiles, Luciana Berod, Tin Duong, Kacey Caradonna, Ajit S. Divakaruni, Michael J. Wolfgang, Alexsander Y. Andreyev, Tim Sparwasser, Brandon R. Desousa, Daniel Braas, David A. Ferrick, George W. Rogers, Marc Liesa, Theodore P. Ciaraldi, Caitlyn E. Bowman, Lucía Minarrieta, Kristen K.O. Kim, Brian P. Dranka, Steven J. Bensinger, Wei Yuan Hsieh, Anne N. Murphy
Publikováno v:
Cell metabolism, vol 28, iss 3
Long-chain fatty acid (LCFA) oxidation has been shown to play an important role in interleukin-4 (IL-4)-mediated macrophage polarization (M(IL-4)). However, many of these conclusions are based on the inhibition of carnitine palmitoyltransferase-1 wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159495c0d1be78d8c409a5323dfdda36
https://escholarship.org/uc/item/7w98t225
https://escholarship.org/uc/item/7w98t225
Autor:
Steven J. Novick, Julie B. Stimmel, George W. Rogers, David A. Ferrick, James B. Mangum, Kennedy L. Queen, Ruolan Wang
Publikováno v:
SLAS Discovery. 20:422-429
Numerous investigations have linked mitochondrial dysfunction to adverse health outcomes and drug-induced toxicity. The pharmaceutical industry is challenged with identifying mitochondrial liabilities earlier in drug development and thereby reducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba141130cca7f77b268b7e62ac44cd0d
https://doi.org/10.1177/1087057114557621
https://doi.org/10.1177/1087057114557621
Autor:
Andrew Neilson, Daniel D. Von Hoff, Ruben M. Munoz, George W. Rogers, Haiyong Han, Pawan Noel
Publikováno v:
Journal of Visualized Experiments : JoVE
Many cancer types, including pancreatic cancer, have a dense fibrotic stroma that plays an important role in tumor progression and invasion. Activated cancer associated fibroblasts are a key component of the tumor stroma that interact with cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2941ac40faa650c2f0b50a21ceb7d39f
https://pubmed.ncbi.nlm.nih.gov/28872142
https://pubmed.ncbi.nlm.nih.gov/28872142
Publikováno v:
Analytical biochemistry. 552
Activities of enzymes localized to the mitochondrial matrix of mammalian cells are often critical regulatory steps in cellular metabolism. As such, measurement of matrix enzyme activities in response to genetic modifications or drug interventions is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8af42a1482c5129cd1f49bdf209e1b7
https://pubmed.ncbi.nlm.nih.gov/28987935
https://pubmed.ncbi.nlm.nih.gov/28987935
Publikováno v:
IEEE Transactions on Geoscience and Remote Sensing. 52:690-700
An approach to the detection of specific polarimetric SAR signatures is presented. The polarimetric response in a resolution cell can be viewed as a sample of the electromagnetic scattering matrix for that resolution cell. Through the use of multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7553f32d678575d4e2f59e670746150f
https://doi.org/10.1109/tgrs.2013.2243737
https://doi.org/10.1109/tgrs.2013.2243737
Autor:
Alexander Y. Andreyev, Alejandro P. Heuck, William G. McDonald, Melvin I. Simon, Robert R. Henry, Estelle A. Wall, Theodore P. Ciaraldi, Sandra E. Wiley, Mattias Loviscach, Nagendra Yadava, David A. Ferrick, Ajit S. Divakaruni, Susanna Petrosyan, George W. Rogers, Anne N. Murphy, Jerry R. Colca
Publikováno v:
Proceedings of the National Academy of Sciences. 110:5422-5427
Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in carbohydrate, amino acid, and lipid metabolism. We report that clinically relevant concentrations of thiazolidinediones (TZDs), a widely used class of insuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba61887b682c43ad1ae60a3af85bdb9
https://doi.org/10.1073/pnas.1303360110
https://doi.org/10.1073/pnas.1303360110