Zobrazeno 1 - 10
of 524
pro vyhledávání: '"George W. Gokel"'
Autor:
Mohit B. Patel, Helena Spikes, Robert S. Bailey, Thomas Connell, Hannah Gill, Michael R. Gokel, Rebecca Harris, Joseph W. Meisel, Saeedeh Negin, Shanheng Andrew Yin, George W. Gokel
Publikováno v:
Antibiotics, Vol 12, Iss 10, p 1513 (2023)
Lariat ethers are macrocyclic polyethers—crown ethers—to which sidearms are appended. 4,13-Diaza-18-crown-6 having twin alkyl chains at the nitrogens show biological activity. They exhibit antibiotic activity, but when co-administered at with an
Externí odkaz:
https://doaj.org/article/8f3ac2720fb5453f89aef58f557f073e
Publikováno v:
International Journal of Biomedical Imaging, Vol 2013 (2013)
Hydraphiles are a class of synthetic ion channels that now have a twenty-year history of analysis and success. In early studies, these compounds were rigorously validated in a wide range of in vitro assays including liposomal ion flow detected by NMR
Externí odkaz:
https://doaj.org/article/79621f5f124a49369be3279e4827440c
Autor:
Harshita Kumari, Saeedeh Negin, Andrew Eisenhart, Mohit B. Patel, Thomas L. Beck, Frank Heinrich, Helena J. Spikes, George W. Gokel
Publikováno v:
RSC advances. 12(49)
Supramolecular interactions are well recognized and many of them have been extensively studied in chemistry. The formation of supramolecular complexes that rely on weak force interactions are less well studied in bilayer membranes. Herein, a supporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f96e3a89852cd3d5b743ccce0696bf
https://pubmed.ncbi.nlm.nih.gov/36415550
https://pubmed.ncbi.nlm.nih.gov/36415550
Autor:
Saeedeh Negin, Joseph W. Meisel, Shanheng Yin, Mohit B. Patel, George W. Gokel, Michael R. Gokel, Michael McKeever
Publikováno v:
Journal of Coordination Chemistry. 74:14-39
Lariat ethers are a variant of crown ethers that have pendant side arms. The original design for these molecules included donor groups in the side arms that were envisioned to enhance alkali metal ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f940359a60d9ab4d1f0951013c55c5f1
https://doi.org/10.1080/00958972.2021.1878352
https://doi.org/10.1080/00958972.2021.1878352
Autor:
Michael R. Gokel, Joseph L Meisel, Saeedeh Negin, George W. Gokel, Shanheng Yin, Hannah Gill, Mohit B. Patel
Publikováno v:
Antibiotics, Vol 10, Iss 1391, p 1391 (2021)
Antibiotics
Volume 10
Issue 11
Antibiotics
Volume 10
Issue 11
The compounds referred to as bis(tryptophan)s (BTs) have shown activity as antimicrobials. The hypothesis that the activity of these novel amphiphiles results from insertion in bilayer membranes and transport of cations is supported by planar bilayer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f831a5d6f47d6c0097d629fd745a53b8
https://www.mdpi.com/2079-6382/10/11/1391
https://www.mdpi.com/2079-6382/10/11/1391
Autor:
Mohit B. Patel, Evan C. Garrad, Sergey L. Sedinkin, Saeedeh Negin, Michael R. Gokel, George W. Gokel, Shanheng Yin, Steven Korb
Publikováno v:
Chemical Science International Journal. :1-19
Aims: The aim of the study was to determine whether and to what extent any of a family of amphiphilic heptapeptide synthetic anion transporters (SATs) affected the growth or root morphology of Arabidopsis thaliana. Study Design: A. thaliana plants we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a87b374a54726d7b331722b0273f2be9
https://doi.org/10.9734/csji/2019/v27i430119
https://doi.org/10.9734/csji/2019/v27i430119
Publikováno v:
Inorganica Chimica Acta. 468:183-191
Bibracchial (two-armed) 4,13-diaza-18-crown-6 lariat ether and tris(macrocycle) hydraphile synthetic amphiphiles alter root morphology in Arabidopsis thaliana plants. The effect on root structure and growth depends both on the hydraphile spacer chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a8ee64abdea26d385bcc7d0a05cf512
https://doi.org/10.1016/j.ica.2017.05.019
https://doi.org/10.1016/j.ica.2017.05.019
Publikováno v:
ChemBioChem. 17:2153-2161
Several N,N'-bis(n-alkyl-4,13-diaza[18]crown-6) lariat ethers were found to significantly enhance the potency of rifampicin and tetracycline, but not erythromycin and kanamycin, against the non-pathogenic DH5α and K-12 strains of Escherichia coli wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0f6ff6542996521aff334d986fc1a8
https://doi.org/10.1002/cbic.201600428
https://doi.org/10.1002/cbic.201600428
Publikováno v:
Supramolecular Chemistry. 29:167-175
Lariat ethers and hydraphiles have been studied by the use of gel electrophoresis to evaluate the complexation of a 10 kilobase plasmid DNA. Both receptor systems show behaviour that reflects differences in side or spacer chain lengths. In addition,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa4263b365258510de022b9e7f9d4c76
https://doi.org/10.1080/10610278.2016.1192170
https://doi.org/10.1080/10610278.2016.1192170
Autor:
Evan C. Garrad, George W. Gokel, Joseph W. Meisel, Ariel Stavri, Saeedeh Negin, Mohit B. Patel, Michael R. Gokel, Zachary T. Cusumano
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2864-2870
Hydraphiles are synthetic amphiphiles that form ion-conducting pores in liposomal membranes. These pores exhibit open-close behavior when studied by planar bilayer conductance techniques. In previous work, we showed that when co-administered with var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b2b28666b86bf00e30120c8d1e1890
https://doi.org/10.1016/j.bmc.2016.04.058
https://doi.org/10.1016/j.bmc.2016.04.058