Zobrazeno 1 - 10
of 91
pro vyhledávání: '"George W, Huntley"'
Autor:
Christopher A. Guevara, Kumayl Alloo, Swati Gupta, Romario Thomas, Pamela del Valle, Alexandra R. Magee, Deanna L. Benson, George W. Huntley
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
Anxiety is a psychiatric non-motor symptom of Parkinson’s that can appear in the prodromal period, prior to significant loss of midbrain dopamine neurons and motor symptoms. Parkinson’s-related anxiety affects females more than males, despite the
Externí odkaz:
https://doaj.org/article/5886914c8c8646169a387baab8423b30
Autor:
Roxana E. Mesías, Yosif Zaki, Christopher A. Guevara, Lauren G. Friedman, Ayan Hussein, Karen Therrien, Alexandra R. Magee, Nikolaos Tzavaras, Pamela Del Valle, Mark G. Baxter, George W. Huntley, Deanna L. Benson
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108002- (2023)
Summary: Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal striatum. To assess how these projections form, we measured PFC axon patterning, synapse formation, and functional maturation in the postnatally developi
Externí odkaz:
https://doaj.org/article/09770c6bebdf46609f5a2a241cfb54ff
Autor:
Mario de la Fuente Revenga, Bohan Zhu, Christopher A. Guevara, Lynette B. Naler, Justin M. Saunders, Zirui Zhou, Rudy Toneatti, Salvador Sierra, Jennifer T. Wolstenholme, Patrick M. Beardsley, George W. Huntley, Chang Lu, Javier González-Maeso
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109836- (2021)
Summary: Clinical evidence suggests that rapid and sustained antidepressant action can be attained with a single exposure to psychedelics. However, the biological substrates and key mediators of psychedelics’ enduring action remain unknown. Here, w
Externí odkaz:
https://doaj.org/article/43705a14b3dc480c8aba3ee0cb75a2bd
Autor:
George W. Huntley, Deanna L. Benson
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Late-onset Parkinson’s disease (PD) is dominated clinically and experimentally by a focus on dopamine neuron degeneration and ensuing motor system abnormalities. There are, additionally, a number of non-motor symptoms – including cognitive and ps
Externí odkaz:
https://doaj.org/article/40cdc1328031423c984c81a66e075d1e
Autor:
Roxana E. Mesías, Yosif Zaki, Christopher A. Guevara, Lauren G. Friedman, Ayan Hussein, Karen Therrien, Alexandra R. Magee, Nikolaos Tzavaras, Pamela Del Valle, Mark G. Baxter, George W. Huntley, Deanna L. Benson
Publikováno v:
bioRxiv
SummaryRational decision making is grounded in learning to associate actions with outcomes, a process that depends on projections from prefrontal cortex to dorsomedial striatum. Symptoms associated with a variety of human pathological conditions rang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec7aef0d88a21300213a857555ecf07
https://doi.org/10.1101/2023.03.14.532475
https://doi.org/10.1101/2023.03.14.532475
Autor:
Sylvain Bouchard, Roger L. Clem, Long Li, Erin S. Calipari, Ralph J. DiLeone, Aki Takahashi, Caroline Menard, Romain Durand-de Cuttoli, Madeline L. Pfau, Kenny L. Chan, Akihiro Yamanaka, Eric J. Nestler, Bridget A. Matikainen-Ankney, Hossein Aleyasin, Katherine B. LeClair, Scott J. Russo, Meghan E. Flanigan, Elizabeth K. Lucas, George W. Huntley, C. Joseph Burnett, Sam A. Golden
Publikováno v:
Nature Neuroscience. 23:638-650
Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have various negative effects on patients, their families and the public. Recent studies in humans and animals have implicated brain reward circuits in aggression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f98771a091dedde965580dc30865c1e4
https://doi.org/10.1038/s41593-020-0617-7
https://doi.org/10.1038/s41593-020-0617-7
Impaired executive function is a common and debilitating non-motor symptom of idiopathic and hereditary Parkinson’s disease (PD), but there is little understanding of the underlying pathophysiological mechanisms and circuits. The G2019S mutation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f836870b760e471fe5620b8ada1ab522
https://doi.org/10.1101/2022.01.26.477929
https://doi.org/10.1101/2022.01.26.477929
Autor:
George W. Huntley, Deanna L. Benson
Publikováno v:
J Comp Neurol
The cardinal motor symptoms that define Parkinson’s disease (PD) clinically have been recognized for over two hundred years. That these symptoms arise following the loss of dopamine neurons in the substantia nigra has been known for the last fifty.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53efac209907f61ed55451e94939d7d1
https://doi.org/10.1002/cne.24642
https://doi.org/10.1002/cne.24642
Autor:
Swati Gupta, Ayan Hussein, Deanna L. Benson, George W. Huntley, Christopher A. Guevara, Pamela Del Valle
Publikováno v:
Neuroscientist
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that has been recognized for over 200 years by its clinically dominant motor system impairment. There are prominent non-motor symptoms as well, and among these, psychiatric sympto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e119fa7f55bc944229556d3ab681bb22
https://pubmed.ncbi.nlm.nih.gov/33966533
https://pubmed.ncbi.nlm.nih.gov/33966533