Zobrazeno 1 - 10
of 19
pro vyhledávání: '"George Van Den Driessche"'
Publikováno v:
Journal of Cheminformatics, Vol 10, Iss 1, Pp 1-24 (2018)
Abstract Background Idiosyncratic adverse drug reactions have been linked to a drug’s ability to bind with a human leukocyte antigen (HLA) protein. However, due to the thousands of HLA variants and limited structural data for drug-HLA complexes, pr
Externí odkaz:
https://doaj.org/article/a7416fa6bf4d41c6af45805bfcc9be0c
Autor:
Jeffrey De Fauw, Pearse Keane, Nenad Tomasev, Daniel Visentin, George van den Driessche, Mike Johnson, Cian O Hughes, Carlton Chu, Joseph Ledsam, Trevor Back, Tunde Peto, Geraint Rees, Hugh Montgomery, Rosalind Raine, Olaf Ronneberger, Julien Cornebise
Publikováno v:
F1000Research, Vol 5 (2017)
There are almost two million people in the United Kingdom living with sight loss, including around 360,000 people who are registered as blind or partially sighted. Sight threatening diseases, such as diabetic retinopathy and age related macular degen
Externí odkaz:
https://doaj.org/article/5ed5147b6f0d4626a23ae8ddd4c84e20
Autor:
Jeffrey De Fauw, Pearse Keane, Nenad Tomasev, Daniel Visentin, George van den Driessche, Mike Johnson, Cian O Hughes, Carlton Chu, Joseph Ledsam, Trevor Back, Tunde Peto, Geraint Rees, Hugh Montgomery, Rosalind Raine, Olaf Ronneberger, Julien Cornebise
Publikováno v:
F1000Research, Vol 5 (2016)
There are almost two million people in the United Kingdom living with sight loss, including around 360,000 people who are registered as blind or partially sighted. Sight threatening diseases, such as diabetic retinopathy and age related macular degen
Externí odkaz:
https://doaj.org/article/96cf58273b6c45d0b87c3428a476d1ff
Autor:
Jennifer Soto, Guojun Chen, Gianpietro Dotti, Peter Abdou, Zejun Wang, Di Wen, Denis Fourches, Yuqi Zhang, Qian Chen, Ming Liu, Song Li, Jinqiang Wang, Masao Ohashi, George Van Den Driessche, Zhen Gu, Hongjun Li, Quanyin Hu
Publikováno v:
Matter. 1:1203-1214
Summary Tumor-associated adipocytes promote tumor growth by providing energy and causing chronic inflammation. Here, we have exploited the lipid metabolism to engineer adipocytes that serve as a depot to deliver cancer therapeutics at the tumor site.
Publikováno v:
The Journal of STEM Outreach. 4
Social media platforms like Twitter offer benefits for promoting and sharing scientific research. Each user becomes an instant news source for their work, and are able to report lab updates, news, and discoveries in near real time, increasing the vis
Photoinduced reconfiguration to control the protein-binding affinity of azobenzene-cyclized peptides
Autor:
Michael A. Daniele, Lewis A Gaffney, Stefano Menegatti, Ashlyn T. Young, Denis Fourches, Raphael Prodromou, Donald O. Freytes, Kevin Day, John D. Schneible, George Van Den Driessche, Vladimir A. Pozdin
Publikováno v:
J Mater Chem B
Journal of Materials Chemistry B
Journal of Materials Chemistry B
The impact of next-generation biorecognition elements (ligands) will be determined by the ability to remotely control their binding activity for a target biomolecule in complex environments. Compared to conventional mechanisms for regulating binding
Autor:
Geven Piir, Paola Gramatica, Vinicius M. Alves, Uko Maran, Xianliang Qiao, Michel Petitjean, Christopher M. Grulke, Karl-Werner Schramm, Giuseppe Felice Mangiatordi, Antony J. Williams, Barun Bhhatarai, Sherif Farag, Alexey V. Zakharov, Chetan Rupakheti, Emilio Benfenati, Weida Tong, Chandrabose Selvaraj, Eva Bay Wedebye, Fang Bai, Sugunadevi Sakkiah, Nicole Kleinstreuer, Ann M. Richard, Orazio Nicolotti, Huixiao Hong, George Van Den Driessche, Ilya A. Balabin, Eugene N. Muratov, Imran Shah, Ulf Norinder, Jiazhong Li, Huanxiang Liu, Viviana Consonni, Igor V. Tetko, Pavel V. Pogodin, Ruili Huang, Ester Papa, Ahmed Abdelaziz, Dragos Horvath, Alexandre Varnek, Patricia Ruiz, Carolina Horta Andrade, Domenico Alberga, Ziye Zheng, Roberto Todeschini, Daniela Trisciuzzi, Nina Jeliazkova, Xuehua Li, Dac-Trung Nguyen, Gilles Marcou, Zhongyu Wang, Kamel Mansouri, Alexander Tropsha, Yun Tang, Alessandro Sangion, Todd M. Martin, Xin Hu, Scott Boyer, Hongbin Xie, Serena Manganelli, Richard S. Judson, Nikolai Georgiev Nikolov, Jingwen Chen, Denis Fourches, Vladimir Poroikov, Alfonso T. García-Sosa, Alessandra Roncaglioni, Davide Ballabio, Patrik L. Andersson, Sulev Sild, Francesca Grisoni, Lixia Sun, Olivier Taboureau
Publikováno v:
Environmental Health Perspectives
Mansouri, K, Kleinstreuer, N, Abdelaziz, A M, Alberga, D, Alves, V M, Andersson, P L, Andrade, C H, Bai, F, Balabin, I, Ballabio, D, Benfenati, E, Bhhatarai, B, Boyer, S, Chen, J, Consonni, V, Farag, S, Fourches, D, García-Sosa, A T, Gramatica, P, Grisoni, F, Grulke, C M, Hong, H, Horvath, D, Hu, X, Huang, R, Jeliazkova, N, Li, J, Li, X, Liu, H, Manganelli, S, Mangiatordi, G F, Maran, U, Marcou, G, Martin, T, Muratov, E, Nguyen, D-T, Nicolotti, O, Nikolov, N G, Norinder, U, Papa, E, Petitjean, M, Piir, G, Pogodin, P, Poroikov, V, Qiao, X, Richard, A M, Roncaglioni, A, Ruiz, P, Rupakheti, C, Sakkiah, S, Sangion, A, Schramm, K-W, Selvaraj, C, Shah, I, Sild, S, Sun, L, Taboureau, O, Tang, Y, Tetko, I V, Todeschini, R, Tong, W, Trisciuzzi, D, Tropsha, A, Van Den Driessche, G, Varnek, A, Wang, Z, Wedebye, E B, Williams, A J, Xie, H, Zakharov, A V, Zheng, Z & Judson, R S 2020, ' CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity ', Environmental Health Perspectives, vol. 128, no. 2, 027002 . https://doi.org/10.1289/ehp5580
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2020, 128 (2), pp.027002. ⟨10.1289/EHP5580⟩
Mansouri, K, Kleinstreuer, N, Abdelaziz, A M, Alberga, D, Alves, V M, Andersson, P L, Andrade, C H, Bai, F, Balabin, I, Ballabio, D, Benfenati, E, Bhhatarai, B, Boyer, S, Chen, J, Consonni, V, Farag, S, Fourches, D, García-Sosa, A T, Gramatica, P, Grisoni, F, Grulke, C M, Hong, H, Horvath, D, Hu, X, Huang, R, Jeliazkova, N, Li, J, Li, X, Liu, H, Manganelli, S, Mangiatordi, G F, Maran, U, Marcou, G, Martin, T, Muratov, E, Nguyen, D-T, Nicolotti, O, Nikolov, N G, Norinder, U, Papa, E, Petitjean, M, Piir, G, Pogodin, P, Poroikov, V, Qiao, X, Richard, A M, Roncaglioni, A, Ruiz, P, Rupakheti, C, Sakkiah, S, Sangion, A, Schramm, K-W, Selvaraj, C, Shah, I, Sild, S, Sun, L, Taboureau, O, Tang, Y, Tetko, I V, Todeschini, R, Tong, W, Trisciuzzi, D, Tropsha, A, Van Den Driessche, G, Varnek, A, Wang, Z, Wedebye, E B, Williams, A J, Xie, H, Zakharov, A V, Zheng, Z & Judson, R S 2020, ' CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity ', Environmental Health Perspectives, vol. 128, no. 2, 027002 . https://doi.org/10.1289/ehp5580
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2020, 128 (2), pp.027002. ⟨10.1289/EHP5580⟩
Background:Endocrine disrupting chemicals (EDCs) are xenobiotics that mimic the interaction of natural hormones and alter synthesis, transport, or metabolic pathways. The prospect of EDCs causing adverse health effects in humans and wildlife has led
Autor:
George Van Den Driessche, Denis Fourches, Tova N. Williams, Alain R. B. Valery, Harold S. Freeman
Publikováno v:
ACS Sustainable Chemistry & Engineering. 6:14248-14256
We report on part 2 of the cheminformatics-assisted development of sustainable hair dyes with enhanced technical and toxicological properties. In this study, an initial similarity search analysis was performed using two reference probes (C.I. Basic O
Autor:
Kareem Ayoub, Trevor Back, Rosalind Raine, Alan Karthikesalingam, Pearse A. Keane, Xavier Glorot, Hugh Montgomery, Julien Cornebise, Demis Hassabis, Daniel Visentin, Brendan O'Donoghue, Adnan Tufail, Catherine A Egan, Jeffrey De Fauw, Olaf Ronneberger, Peng T. Khaw, Harry Askham, Reena Chopra, Faith Mackinder, Joseph R. Ledsam, Dominic King, Nenad Tomasev, Julian Hughes, Simon Bouton, Clemens Meyer, George van den Driessche, Cian Hughes, Stanislav Nikolov, Mustafa Suleyman, Balaji Lakshminarayanan, Dawn A Sim, Bernardino Romera-Paredes, Sam Blackwell, Geraint Rees
Publikováno v:
Nature Medicine. 24:1342-1350
The volume and complexity of diagnostic imaging is increasing at a pace faster than the availability of human expertise to interpret it. Artificial intelligence has shown great promise in classifying two-dimensional photographs of some common disease
Publikováno v:
Computational Toxicology