Zobrazeno 1 - 6
of 6
pro vyhledávání: '"George V Aslanidi"'
Autor:
Awilda M Rosario, Pedro E Cruz, Carolina Ceballos-Diaz, Michael R Strickland, Zoe Siemienski, Meghan Pardo, Keri-Lyn Schob, Andrew Li, George V Aslanidi, Arun Srivastava, Todd E Golde, Paramita Chakrabarty
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy applications for central nervous system diseases. Though rAAV can efficiently target neurons and astrocytes in mouse brains, microglia, the immune cells of the brain, a
Externí odkaz:
https://doaj.org/article/97a40b710dcb4b2eb9bbcd9f5345793e
Autor:
Christine N Kay, Renee C Ryals, George V Aslanidi, Seok Hong Min, Qing Ruan, Jingfen Sun, Frank M Dyka, Daniel Kasuga, Andrea E Ayala, Kim Van Vliet, Mavis Agbandje-McKenna, William W Hauswirth, Sanford L Boye, Shannon E Boye
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62097 (2013)
Development of viral vectors capable of transducing photoreceptors by less invasive methods than subretinal injection would provide a major advancement in retinal gene therapy. We sought to develop novel AAV vectors optimized for photoreceptor transd
Externí odkaz:
https://doaj.org/article/acb82117f6a642269cce77147bb4a790
Autor:
George V Aslanidi, Angela E Rivers, Luis Ortiz, Liujiang Song, Chen Ling, Lakshmanan Govindasamy, Kim Van Vliet, Mengqun Tan, Mavis Agbandje-McKenna, Arun Srivastava
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59142 (2013)
The ubiquitin-proteasome pathway plays a critical role in the intracellular trafficking of AAV2 vectors, and phosphorylation of certain surface-exposed amino acid residues on the capsid provides the primary signal for ubiquitination. Removal of sever
Externí odkaz:
https://doaj.org/article/ad3cc4e20a7a4d0b901038d575181fd8
Autor:
Liujiang Song, Xiaomiao Li, Giridhara R Jayandharan, Yuan Wang, George V Aslanidi, Chen Ling, Li Zhong, Guangping Gao, Mervin C Yoder, Changquan Ling, Mengqun Tan, Arun Srivastava
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58757 (2013)
We have observed that of the 10 AAV serotypes, AAV6 is the most efficient in transducing primary human hematopoietic stem cells (HSCs), and that the transduction efficiency can be further increased by specifically mutating single surface-exposed tyro
Externí odkaz:
https://doaj.org/article/f6f6b42546ea4658bef5d154256e79ef
Autor:
Geoffrey L Rogers, Ashley T Martino, George V Aslanidi, Giridhara R Jayandharan, Arun eSrivastava, Roland W. Herzog
Publikováno v:
Frontiers in Microbiology, Vol 2 (2011)
Gene replacement therapy by in vivo delivery of adeno-associated virus (AAV) is attractive as a potential treatment for a variety of genetic disorders. However, while AAV has been used successfully in many models, other experiments in clinical trials
Externí odkaz:
https://doaj.org/article/adfbdf359ff546ca991f775753ec380a
Autor:
Christine N. Kay, Renee C. Ryals, George V. Aslanidi, Seok Hong Min, Qing Ruan, Jingfen Sun, Frank M. Dyka, Daniel Kasuga, Andrea E. Ayala, Kim Van Vliet, Mavis Agbandje-McKenna, William W. Hauswirth, Sanford L. Boye, Shannon E. Boye
Publikováno v:
PLoS ONE, Vol 8, Iss 9 (2013)
Externí odkaz:
https://doaj.org/article/1e7d397ee6504d4991261a14ef4ad389