Zobrazeno 1 - 10
of 23
pro vyhledávání: '"George Treacy"'
Autor:
Carrie Brodmerkel, Charles Pendley, Mary Ann Mascelli, Gopi Shankar, Jacqueline Benson, Honghui Zhou, Clifford Sachs, George Treacy
Publikováno v:
Nature Biotechnology. 29:615-624
Preclinical and clinical studies conducted in the mid-1990s reported strong association and causality between the T-cell helper (T(H)) 1 inductor cytokine interleukin (IL)-12 and numerous immune-mediated disorders, which spurred the development of th
Autor:
George Treacy, Clifford Sachs, Pauline L. Martin, Satoru Oneda, Noritaka Imai, Hideshi Tsusaki, Qun Jiao
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 89:351-363
BACKGROUND: Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of interleukin (IL) 12 and IL-23 and inhibits their pharmacological activity. To evaluate potential effects of ustekinumab treatment during pregnancy, developmental
Autor:
Joseph Marini, Alan M. Hoberman, Kimber L. White, Joel Cornacoff, George Treacy, Pauline L. Martin, Vanessa L. Peachee, Edward Eirikas
Publikováno v:
International Journal of Toxicology. 27:341-347
Monoclonal antibodies directed against tumor necrosis factor alpha (TNFalpha) are currently employed in the treatment of various immune-mediated diseases. These studies were designed to evaluate potential effects of anti-TNFalpha treatment in mice du
Publikováno v:
Journal of Immunotherapy. 15:251-256
The IgG1 kappa human monoclonal antibody (HMab), F105 reacts with a discontinuous epitope on the CD4 binding site (CD4BS) of human immunodeficiency virus type 1 (HIV-1)/gp120 and has broad neutralizing activity. F105 HMab (60 mg/kg bolus) was adminis
Autor:
Carrie, Brodmerkel, Yaowei, Zhu, Qun, Jiao, Joel, Cornacoff, George, Treacy, Mary Ann, Mascelli, Alice B, Gottlieb
Publikováno v:
Journal of drugs in dermatology : JDD. 9(6)
Ustekinumab, a fully human immunoglobulin (Ig) G1K monoclonal antibody directed against the p40 subunit of interleukin (IL)-12/23, has demonstrated efficacy in patients with moderate-to-severe psoriasis.To evaluate the effect of IL-12/23 inhibition o
Autor:
Peter J. Bugelski, Ram Achuthanandam, George Treacy, Renold J. Capocasale, Esther Bouman-Thio
Publikováno v:
Expert review of clinical immunology. 5(5)
Monoclonal antibodies (mAbs) are widely used in anti-inflammatory and tumor therapy. Although effective, mAbs can cause a variety of adverse effects. An important toxicity seen with a few mAbs is cytokine-release syndrome (CRS). These mAbs include: a
Autor:
Pauline L. Martin, George Treacy
Publikováno v:
Pharmaceutical Sciences Encyclopedia
Monoclonal antibodies are populations of identical, monospecific antibodies with defined specificity and affinity for a target antigen. The design of preclinical safety evaluation of monoclonal antibodies is based on the class of monoclonal, the targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3766ca71b7c361ba787ac9495777aca2
https://doi.org/10.1002/9780470571224.pse185
https://doi.org/10.1002/9780470571224.pse185
Publikováno v:
Pharmaceutical Sciences Encyclopedia ISBN: 9780470571224
Pharmaceutical Sciences Encyclopedia
Pharmaceutical Sciences Encyclopedia
A number of immunomodulatory biopharmaceuticals (IMBPs), such as peptides, recombinant proteins, and monoclonal antibodies, have been approved or are currently in development to treat chronic inflamatory diseases. IMBPs by virtue of their intended ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af912f5609b92a835074999b49d37716
https://doi.org/10.1002/9780470571224.pse186
https://doi.org/10.1002/9780470571224.pse186
Autor:
Allen Schantz, George Treacy, Deborah Kwok, Qun Jiao, Gordon Powers, Kathleen Van den Bulck, Zhao Zhou, Pauline L. Martin
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology.
BACKGROUND: Intetumumab is a human IgG1 anti-αv-integrin monoclonal antibody that inhibits angiogenesis. Integrin binding and angiogenesis are important in reproduction including fertilization, implantation, and embryofetal development. These studie