Zobrazeno 1 - 10
of 21
pro vyhledávání: '"George Torosian"'
Publikováno v:
Journal of Pharmaceutical Sciences. 81:586-591
The degradation kinetics of moricizine hydrochloride (1) were examined over a pH range of 0.6 to 6.0 at an ionic strength of 0.3 and 60 degrees C. The disappearance of intact 1 was followed by a stability-indicating HPLC assay. The degradation produc
Publikováno v:
Pharmaceutical Research. :1325-1328
Publikováno v:
Journal of Pharmaceutical Sciences. 83:1404-1406
The antiarrhythmic agent moricizine hydrochloride exhibits a single melting-decomposition endotherm peak at temperatures ranging from 209 to 214.5 degrees C (Form I) when recrystallized from polar solvents, as determined by differential scanning calo
Autor:
David Coffin-Beach, Arthur R. Hurwitz, George Torosian, Robert C. Diluccio, Munir A. Hussain, Eli Shefter
Publikováno v:
Journal of pharmaceutical sciences. 83(1)
Crystalline polyvinyl alcohol (PVA) polymer and low-crystallinity polyvinyl alcohol-methyl acrylate copolymer (PVA-MA) were examined as sustained-release tablet excipients with theophylline as a model drug. By blending of different proportions of the
Publikováno v:
Drug Intelligence & Clinical Pharmacy. 14:605-608
A study was designed to determine if the admixture of phenytoin in normal saline would remain physically stable for a suitable period of time to allow for intravenous infusion. Five phenytoin concentrations (1.0 mg/ml, 2.5 mg/ml, 5.0 mg/ml, 7.5 mg/ml
Publikováno v:
American Journal of Health-System Pharmacy. 32:817-821
The stability of methyldopa in two extemporaneous syrup preparations was studied. Film-coated methyldopa tablets were triturated and incorporated into (1) unpreserved Syrup USP and (2) an equal mixture of simple syrup containing 0.5% citric acid and
Publikováno v:
Journal of Pharmaceutical Sciences. 70:981-984
The pharmacokinetic profile of sulfisoxazole was studied and compared in dogs, swine, and humans. The trial was conducted over a 72-hr period after intravenous administration and a 96-hr period after oral administration in dogs and swine. In humans,
Publikováno v:
American Journal of Health-System Pharmacy. 33:1294-1297
The effect of orange juice consumption on urinary pH was studied in seven adult male subjects, each of whom served as his own control. The diet of the subjects was standardized during the work-day. The effects of two regimens of orange juice were stu
Publikováno v:
American Journal of Health-System Pharmacy. 32:912-917
The stability and the behavior of patent blue (Alphazurine 2G) dye in a vehicle such as lidocaine hydrochloride injection were studied with regard to medication orders which may be prepared by hospital pharmacists. The patent blue family of dyes are
Autor:
Robert C. DiLuccio, Munir A. Hussain, David Coffin-Beach, George Torosian, Eli Shefter, Arthur R. Hurwitz
Publikováno v:
Pharmaceutical Research. :844-847
Low crystalline and crystalline polyvinyl alcohol-methyl acrylate (PVA-MA) copolymers were examined, because of their excellent flow and compressibility properties, as matrices for sustained-release tablets using phenylpropanolamine hydrochloride (PP