Zobrazeno 1 - 4
of 4
pro vyhledávání: '"George Todd Milne"'
Autor:
Regina Graul, Jennifer G. Chickering, Daniel P. Zimmer, Yueh-Tyng Chien, George Todd Milne, Jaime L. Masferrer, John R. Hadcock, Emmanuel S. Buys, Albert T. Profy
Publikováno v:
Nitric Oxide. 78:72-80
Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC), an enzyme that catalyzes the conversion of guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophophate (cGMP), transduces many of the physiological effects of the gasotransmitter
Autor:
George Todd Milne, Chad D. Schwartzkopf, Juli E. Jones, John R. Hadcock, Jaime L. Masferrer, Mark G. Currie
Publikováno v:
Diabetes. 67
Background: Praliciguat (IW-1973) is a soluble guanylate cyclase (sGC) stimulator in clinical development. In animal models, praliciguat has broad tissue distribution and enhances nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling, whi
Autor:
Mark G. Currie, Raj Iyengar, Renee Sarno, Brandon Nguyen, Thomas W.-H. Lee, Guang Liu, Daniel P. Zimmer, Susana S. Correia, George Todd Milne, Emily Atwater, Victoria Catanzano, Sarah Jacobson, Sylvie G. Bernier, Kim Tang, John R. Hadcock
Publikováno v:
The FASEB Journal. 32
Publikováno v:
Molecular and Cellular Biology. 16:4189-4198
DNA double-strand break (DSB) repair in mammalian cells is dependent on the Ku DNA binding protein complex. However, the mechanism of Ku-mediated repair is not understood. We discovered a Saccharomyces cerevisiae gene (KU80) that is structurally simi