Zobrazeno 1 - 10
of 17
pro vyhledávání: '"George T. Tkalcevic"'
Autor:
Ronald W. Clark, David Cunningham, Yang Cong, Timothy A. Subashi, George T. Tkalcevic, David B. Lloyd, James G. Boyd, Boris A. Chrunyk, George A. Karam, Xiayang Qiu, Ing-Kae Wang, Omar L. Francone
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 967-974 (2010)
The CETP inhibitor, torcetrapib, was prematurely terminated from phase 3 clinical trials due to an increase in cardiovascular and noncardiovascular mortality. Because nearly half of the latter deaths involved patients with infection, we have tested t
Externí odkaz:
https://doaj.org/article/90ebce87c8a64100a15f3130a1645823
Autor:
Michael Herr, James R. Gosset, Steven B. Coffey, Jana Polivkova, Timothy A. Subashi, Kay Ahn, Philip A. Carpino, Magee Thomas Victor, Brandon Pabst, Kevin B. Bahnck, Kim Huard, Kou Kou, David Hepworth, Kyuha Lee, Gregory J. Tesz, Allyn T. Londregan, Csilla C. Jorgensen, Anu Nigam, Hao Sun, Christian Perreault, Bryan Goodwin, Qifang Li, Markus Boehm, George T. Tkalcevic
Publikováno v:
Journal of Medicinal Chemistry. 58:7164-7172
Inhibition of triacylglycerol (TAG) biosynthetic enzymes has been suggested as a promising strategy to treat insulin resistance, diabetes, dyslipidemia, and hepatic steatosis. Monoacylglycerol acyltransferase 3 (MGAT3) is an integral membrane enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff3cfbe5a414f8fbc55e9bc5c4d6884
https://doi.org/10.1021/acs.jmedchem.5b01008
https://doi.org/10.1021/acs.jmedchem.5b01008
Autor:
Jean S. Beebe, William M. Hungerford, Nandini Chaturbhai Patel, Heather N. Frost, Susan Deborah Lagreca, Cathy Soderstrom, Shefali Kakar, Doug Savage, Matthew David Wessel, Matthew A. Marx, Merin Boehm, Thompson Carl Brian, Jinshan M. Chen, Connell Richard D, Nandell F. Keene, Elizabeth Knauth, Gary Borzillo, Aaron Kanter, Yong Lu, Joel Morris, Martin A. Berliner, Patrick Vincent, Bruce D. Cohen, George T. Tkalcevic, Joel T. Arcari, Deborah A. Gordon, James J. Valentine, Tracey Clark, Louis Martinez-Alsina, Vincent Bernardo, Felix Vajdos, Norma Jacqueline Tom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3059-3063
The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are described, including the benzimidazole series by linking a benzimidazole to the C5-position of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4094fb50746e9612e49cef7a5bc7bf6
https://doi.org/10.1016/j.bmcl.2013.03.012
https://doi.org/10.1016/j.bmcl.2013.03.012
Autor:
Michael Robbins, George T. Tkalcevic, Nandini Chaturbhai Patel, Michael John Munchhof, Andrei Shavnya, Qifang Li, Christopher S. Jones, Susan Deborah Lagreca, Gary Borzillo, Tracey Boyden, Larry A Reiter, Kathleen Pelletier, Luis Martinez-Alsina
Publikováno v:
ACS Medicinal Chemistry Letters. 3:106-111
Inhibitors of the Hedgehog signaling pathway have generated a great deal of interest in the oncology area due to the mounting evidence of their potential to provide promising therapeutic options for patients. Herein, we describe the discovery strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab465e54e0b2acbf6ad632b3284f050c
https://doi.org/10.1021/ml2002423
https://doi.org/10.1021/ml2002423
Autor:
David Cunningham, James G. Boyd, George T. Tkalcevic, Ing-Kae Wang, George A. Karam, Omar L. Francone, Yang Cong, Ronald W. Clark, Boris A. Chrunyk, Timothy A. Subashi, Xiayang Qiu, David B. Lloyd
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 967-974 (2010)
The CETP inhibitor, torcetrapib, was prematurely terminated from phase 3 clinical trials due to an increase in cardiovascular and noncardiovascular mortality. Because nearly half of the latter deaths involved patients with infection, we have tested t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bbd88c4759cf609d68773ef8e9b2ba
http://www.sciencedirect.com/science/article/pii/S002222752041051X
http://www.sciencedirect.com/science/article/pii/S002222752041051X
Autor:
Amy L. Mansolf, Hua Zhu Ke, Lori C. Gowen, Hollis A. Simmons, George T. Tkalcevic, John D. McNeish, Thomas A. Brown, Kristen L. Chidsey-Frink, D.T. Crawford, Hong Qi, Jeffrey L. Stock, Donna N. Petersen
Publikováno v:
Journal of Biological Chemistry. 278:1998-2007
We have previously described osteoblast/osteocyte factor 45 (OF45), a novel bone-specific extracellular matrix protein, and demonstrated that its expression is tightly linked to mineralization and bone formation. In this report, we have cloned and ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa726514d701f741436f5d1085d19b0
https://doi.org/10.1074/jbc.m203250200
https://doi.org/10.1074/jbc.m203250200
Autor:
George T. Tkalcevic, Thomas A. Brown, Donna N. Petersen, Ramon Rivera-Gonzalez, Amy L. Mansolf
Publikováno v:
Journal of Biological Chemistry. 275:36172-36180
We describe the cloning and characterization of a novel bone-specific cDNA predicted to encode an extracellular matrix protein. This cDNA was identified by subtractive hybridization based upon its high expression in bone marrow-derived osteoblasts. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24320f426b7505607204c0b51733975
https://doi.org/10.1074/jbc.m003622200
https://doi.org/10.1074/jbc.m003622200
Autor:
Nancy C. Elliott, D.T. Crawford, Thomas A. Brown, Lydia C. Pan, Hua Zhu Ke, Christina M. Tjoa, George T. Tkalcevic, M. J. Cole, D.D. Thompson, C.M. Pirie, Anthony R. Reinhold, Brad Newhouse, P. M. Sweetnam, Robert L. Rosati, Steven M. Toler, Hong Qi, J. W. Gauthier, P. Da Silva Jardine, M. W. Arriola, C. F. Ebbinghaus, Kimberly O. Cameron, H.A. Simmons, David F. Nickerson
Publikováno v:
Journal of Medicinal Chemistry. 41:2928-2931
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6d891ef0fa59ae1786f1c7b9a3e97c
https://doi.org/10.1021/jm980048b
https://doi.org/10.1021/jm980048b
Publikováno v:
Endocrinology. 139:1082-1092
The effects of estrogen and estrogen agonists can be mediated by estrogen receptor alpha (ER alpha) and estrogen receptor beta (ER beta). We now report the identification and initial characterization of several novel isoforms of rat ER beta messenger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0548b75c8246b9157f8717914c2eadcf
https://doi.org/10.1210/endo.139.3.5840
https://doi.org/10.1210/endo.139.3.5840
Autor:
Donna N. Petersen, David D. Thompson, Thomas A. Brown, George T. Tkalcevic, Ramon Rivera-Gonzalez
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 64:13-24
The identification and characterization of estrogen regulated genes in reproductive tissues is an important step in understanding estrogen's mechanism of action in sexual development and neoplasia. It is also important, given the clinical interest, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050ac469cae41698710d06e54cf43dbf
https://doi.org/10.1016/s0960-0760(97)00142-8
https://doi.org/10.1016/s0960-0760(97)00142-8