Zobrazeno 1 - 10
of 44
pro vyhledávání: '"George T. Stevenson"'
Autor:
George T. Stevenson
Publikováno v:
Haematologica, Vol 99, Iss 10 (2014)
Antibodies against surface molecules of human tumors are now frequently administered in combination with strong chemotherapy, increasing therapeutic efficacy but making the task of elucidating immunological events more difficult. Experiments on genet
Externí odkaz:
https://doaj.org/article/2663aa50a72741febe92f5cc22f3f78b
Autor:
George T. Stevenson
Publikováno v:
Leukemia Research. 29:239-246
Evidence suggests that amelioration of childhood immune thrombocytopenic purpura and some other autoimmune states by intravenous normal IgG is due to the following chain of events: (1) cross-linking of Fcγ-receptors on blood effector cells; (2) rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c0c3de77aec8c03550e90e22fadddde
https://doi.org/10.1016/j.leukres.2004.08.001
https://doi.org/10.1016/j.leukres.2004.08.001
Autor:
Weng S. Leong, Valerie A. Anderson, Andrew Worth, Andrew M. Smith, George T. Stevenson, Kwok S. Kan
Publikováno v:
The Journal of Immunology. 166:1320-1326
We describe a two-stage preparation of chemically engineered Ab constructs, employing as modules Fab′γ from mAb or rAb, and Fc from human normal IgG1. A multivalent, optionally multispecific F(ab′)n core is formed in stage one, and one or more F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bdb997de8331265a97df7b9b0e66e9
https://doi.org/10.4049/jimmunol.166.2.1320
https://doi.org/10.4049/jimmunol.166.2.1320
Autor:
Mark S. Cragg, George T. Stevenson
Publikováno v:
Seminars in Cancer Biology. 9:139-147
Molecular mapping of the cell surface has probably proceeded further with the human lymphocyte than with any other mammalian cell, and the B lymphocyte yields a wide range of subtly varying neoplasms. These two bodies of knowledge are now readily cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c9f84819a078cb8da4952945974d7e
https://doi.org/10.1006/scbi.1998.0085
https://doi.org/10.1006/scbi.1998.0085
Publikováno v:
Blood. 119(16)
Follicular lymphoma (FL) is a B-cell tumor arising in germinal centers and retaining features of its normal B-cell counterpart. Lymphomagenesis appears stepwise from the t(14;18) translocation, through FL-like cells, to FL in situ, then to overt FL.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160d1fbad0083f7aef5f3c3350c2ac50
https://pubmed.ncbi.nlm.nih.gov/22337721
https://pubmed.ncbi.nlm.nih.gov/22337721
Autor:
George T. Stevenson
Publikováno v:
Leukemia Research. 18:395-399
Our discussion is summarized in Fig. 1. Cytotoxic drugs are shown with the classical sigmoid relationship of response to log dose, with a parallel increase in toxicity which suits the Phase I approach. With antibody it is doubtful that clinical tumou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d22821be95007b9eed75f37ce9a0316
https://doi.org/10.1016/0145-2126(94)90074-4
https://doi.org/10.1016/0145-2126(94)90074-4
Publikováno v:
Molecular immunology. 48(5)
This work aims to enhance killing of antibody-coated human tumor cells by altering the antibody's affinity for two effector-cell Fcγ-receptors (FcγR). Affinity for the activating FcγRIII is raised, affinity for the inhibitory FcγRIIB is reduced,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6de4e434917e6633c96cf967975092
https://pubmed.ncbi.nlm.nih.gov/21196049
https://pubmed.ncbi.nlm.nih.gov/21196049
Autor:
John Greenman, Christopher J. Slade, George T. Stevenson, Suzanne Nikoletti, Nancy Hogg, Martin J. Glennie
Publikováno v:
Cancer Immunology Immunotherapy. 34:361-369
The three forms of Fc gamma receptor carried by monocytes (Fc gamma RI, II) and natural killer (NK) cells (Fc gamma RIII) are all capable of mediating cell lysis. Here we compare the use of F(ab'gamma)2 bispecific antibodies, specifically targetting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b796e138f2f7b8b01159034f30ba41b
https://doi.org/10.1007/bf01741745
https://doi.org/10.1007/bf01741745
Autor:
Andrew J.T. George, K.A.F. Pulford, Martin J. Glennie, Alison L. Tutt, J. Greenman, George T. Stevenson
Publikováno v:
Molecular Immunology. 28:1243-1254
Fc gamma RII (CDw32) on monocytes is capable of triggering both phagocytosis and lysis of chick red blood cells (CRBC) coated with antibody of the appropriate isotype. In this report we describe the production and characterization of a mouse monoclon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ab4831598cbe949f5ec2307a083043
https://doi.org/10.1016/0161-5890(91)90011-8
https://doi.org/10.1016/0161-5890(91)90011-8
Autor:
Terence J. Hamblin, Freda K. Stevenson, Christopher J. Slade, Rebecca Cusack, George T. Stevenson, Andrew J. Bell, M B Spellerberg
Publikováno v:
Blood. 77:1071-1079
Multiple myeloma is a disease in which conventional chemotherapy has only limited value, but which may be ideal for treatment with passive antibody against a suitable cell surface antigen on the neoplastic plasma cell. The CD38 antigen is known to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb0d08e9f72149382c6bb52916695ea1
https://doi.org/10.1182/blood.v77.5.1071.1071
https://doi.org/10.1182/blood.v77.5.1071.1071