Zobrazeno 1 - 10
of 31
pro vyhledávání: '"George T. De Sanctis"'
Autor:
Jeffrey M. Drazen, George T. De Sanctis, Lester Kobzik, Venkat Subramaniam, Stephanie A. Shore, Joseph Vallone, Shoji Okinaga, Josephine Hjoberg, Eric S. Silverman, Jack A. Elias, Arlene Hallock
Publikováno v:
Journal of Applied Physiology. 97:249-259
Individuals with asthma have increased levels of nitric oxide in their exhaled air. To explore its role, we have developed a regulatable transgenic mouse capable of overexpressing inducible nitric oxide synthase in a lung-specific fashion. The CC10-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b43329c9c9b9e07280397126c3981b3
https://doi.org/10.1152/japplphysiol.01389.2003
https://doi.org/10.1152/japplphysiol.01389.2003
Publikováno v:
The Journal of Immunology. 168:4764-4771
Inflammatory responses induced by allergen exposure cause mucous cell metaplasia (MCM) by differentiation of existing and proliferating epithelial cells into mucus-storing cells. Airway epithelia have various mechanisms that resolve these changes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63dea8d0a432d3340181f1a64f97c5a5
https://doi.org/10.4049/jimmunol.168.9.4764
https://doi.org/10.4049/jimmunol.168.9.4764
Publikováno v:
Clinical Pulmonary Medicine. 8:59-65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0a3dc630acc7bba40da9a7deaed6b1f
https://doi.org/10.1097/00045413-200103000-00001
https://doi.org/10.1097/00045413-200103000-00001
Autor:
Jeffrey M. Drazen, Alain Sauty, Israel F. Charo, George T. De Sanctis, Kate G. Ackerman, James A. MacLean, Elliot DeHaan, Francis H. Y. Green, Andrew D. Luster
Publikováno v:
The Journal of Immunology. 165:6568-6575
Monocyte chemoattractant proteins-1 and -5 have been implicated as important mediators of allergic pulmonary inflammation in murine models of asthma. The only identified receptor for these two chemokines to date is the CCR2. To study the role of CCR2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a6245d21847124c155ba3e237e748c
https://doi.org/10.4049/jimmunol.165.11.6568
https://doi.org/10.4049/jimmunol.165.11.6568
Autor:
Carolyn E. Donovan, David A. Mark, Hong Zhen He, Hsiou-Chi Liou, Lester Kobzik, Yunsheng Wang, George T. De Sanctis, David L. Perkins, Patricia W. Finn
Publikováno v:
The Journal of Immunology. 163:6827-6833
The NF-κB/Rel family of transcription factors induces many genes involved in immune and inflammatory responses. Mice with germline deletions of individual NF-κB/Rel subunits have different phenotypes, suggesting that the NF-κB/Rel transcription fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f37ed775efe89be447056e54a129c55a
https://doi.org/10.4049/jimmunol.163.12.6827
https://doi.org/10.4049/jimmunol.163.12.6827
Autor:
Eric S. Silverman, Kwang Ho In, Tim P. Keith, David R. Beier, Koichiro Asano, Andrew R. Fischer, George T. De Sanctis, Kristina Serino, Chandri N. Yandava, Jeffrey M. Drazen
Publikováno v:
Clinical Reviews in Allergy & Immunology. 17:59-69
Our data demonstrate the presence of a naturally occurring family of alleles in the core promoter of the 5-LO gene, which is characterized by the deletion or addition of consensus Sp1 (-GGGCGG) and Egr-1 (-GCGGGGGCG-) binding motifs. Each of the vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6148043de6f284d1ff428fbb15817d
https://doi.org/10.1007/bf02737597
https://doi.org/10.1007/bf02737597
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:379-387
Murine models of allergen-induced pulmonary inflammation share many features with human asthma, including the development of antigen-induced pulmonary eosinophilia, airway hyperresponsiveness, antigen-specific cellular and antibody responses, the ela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e55d1070b40dd043e5fd39b60ce95cc
https://doi.org/10.1165/ajrcmb.20.3.3291
https://doi.org/10.1165/ajrcmb.20.3.3291
Autor:
Hartmut Grasemann, Paul L. Huang, Changaram S. Venugopal, Lester Kobzik, Kaoru Hamada, Aiping Jiao, Jeffrey M. Drazen, James A. MacLean, George T. De Sanctis, Chandri N. Yandava, Jeremy A. Scott, Sanjay Mehta, Attila J. Fabian, Walter W. Wolyniec
Publikováno v:
The Journal of Experimental Medicine
Asthma is a chronic disease characterized by increased airway responsiveness and airway inflammation. The functional role of nitric oxide (NO) and the various nitric oxide synthase (NOS) isoforms in human asthma is controversial. To investigate the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577d3c600822c3cda8904000303c4d22
http://europepmc.org/articles/PMC2193630
http://europepmc.org/articles/PMC2193630
Autor:
James A. Listman, George T. De Sanctis, Manuela Cernadas, Lester Kobzik, David L. Perkins, David C. Christiani, Hitoshi Kikutani, Patricia W. Finn, Carolyn E. Donovan, S J Krinzman, David A. Mark
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:1-8
CD23, a receptor for immunoglobulin E, is expressed at increased levels in asthmatic and atopic individuals and has been associated with disorders characterized by chronic inflammation. Using an established murine model, we employed several complemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bec2c884ceb92c8e38eb14e8e881c75
https://doi.org/10.1165/ajrcmb.20.1.3299
https://doi.org/10.1165/ajrcmb.20.1.3299
Autor:
Sanjay Mehta, Aiping Jiao, Jeffrey M. Drazen, Chandri N. Yandava, George T. De Sanctis, Paul L. Huang, Lester Kobzik
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 273:L883-L888
Nitric oxide (NO) can be measured in the expired gas of humans and animals, but the source of expired NO (FENO) and the functional contribution of the various known isoforms of NO synthase (NOS) to the NO measured in the expired air is not known. FEN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de262fd88be303dae3d6acb47e908494
https://doi.org/10.1152/ajplung.1997.273.4.l883
https://doi.org/10.1152/ajplung.1997.273.4.l883