Zobrazeno 1 - 10
of 31
pro vyhledávání: '"George T. De Sanctis"'
Autor:
Jeffrey M. Drazen, George T. De Sanctis, Lester Kobzik, Venkat Subramaniam, Stephanie A. Shore, Joseph Vallone, Shoji Okinaga, Josephine Hjoberg, Eric S. Silverman, Jack A. Elias, Arlene Hallock
Publikováno v:
Journal of Applied Physiology. 97:249-259
Individuals with asthma have increased levels of nitric oxide in their exhaled air. To explore its role, we have developed a regulatable transgenic mouse capable of overexpressing inducible nitric oxide synthase in a lung-specific fashion. The CC10-r
Publikováno v:
The Journal of Immunology. 168:4764-4771
Inflammatory responses induced by allergen exposure cause mucous cell metaplasia (MCM) by differentiation of existing and proliferating epithelial cells into mucus-storing cells. Airway epithelia have various mechanisms that resolve these changes to
Publikováno v:
Clinical Pulmonary Medicine. 8:59-65
Autor:
Jeffrey M. Drazen, Alain Sauty, Israel F. Charo, George T. De Sanctis, Kate G. Ackerman, James A. MacLean, Elliot DeHaan, Francis H. Y. Green, Andrew D. Luster
Publikováno v:
The Journal of Immunology. 165:6568-6575
Monocyte chemoattractant proteins-1 and -5 have been implicated as important mediators of allergic pulmonary inflammation in murine models of asthma. The only identified receptor for these two chemokines to date is the CCR2. To study the role of CCR2
Autor:
Carolyn E. Donovan, David A. Mark, Hong Zhen He, Hsiou-Chi Liou, Lester Kobzik, Yunsheng Wang, George T. De Sanctis, David L. Perkins, Patricia W. Finn
Publikováno v:
The Journal of Immunology. 163:6827-6833
The NF-κB/Rel family of transcription factors induces many genes involved in immune and inflammatory responses. Mice with germline deletions of individual NF-κB/Rel subunits have different phenotypes, suggesting that the NF-κB/Rel transcription fa
Autor:
Eric S. Silverman, Kwang Ho In, Tim P. Keith, David R. Beier, Koichiro Asano, Andrew R. Fischer, George T. De Sanctis, Kristina Serino, Chandri N. Yandava, Jeffrey M. Drazen
Publikováno v:
Clinical Reviews in Allergy & Immunology. 17:59-69
Our data demonstrate the presence of a naturally occurring family of alleles in the core promoter of the 5-LO gene, which is characterized by the deletion or addition of consensus Sp1 (-GGGCGG) and Egr-1 (-GCGGGGGCG-) binding motifs. Each of the vari
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:379-387
Murine models of allergen-induced pulmonary inflammation share many features with human asthma, including the development of antigen-induced pulmonary eosinophilia, airway hyperresponsiveness, antigen-specific cellular and antibody responses, the ela
Autor:
Hartmut Grasemann, Paul L. Huang, Changaram S. Venugopal, Lester Kobzik, Kaoru Hamada, Aiping Jiao, Jeffrey M. Drazen, James A. MacLean, George T. De Sanctis, Chandri N. Yandava, Jeremy A. Scott, Sanjay Mehta, Attila J. Fabian, Walter W. Wolyniec
Publikováno v:
The Journal of Experimental Medicine
Asthma is a chronic disease characterized by increased airway responsiveness and airway inflammation. The functional role of nitric oxide (NO) and the various nitric oxide synthase (NOS) isoforms in human asthma is controversial. To investigate the r
Autor:
James A. Listman, George T. De Sanctis, Manuela Cernadas, Lester Kobzik, David L. Perkins, David C. Christiani, Hitoshi Kikutani, Patricia W. Finn, Carolyn E. Donovan, S J Krinzman, David A. Mark
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:1-8
CD23, a receptor for immunoglobulin E, is expressed at increased levels in asthmatic and atopic individuals and has been associated with disorders characterized by chronic inflammation. Using an established murine model, we employed several complemen
Autor:
Sanjay Mehta, Aiping Jiao, Jeffrey M. Drazen, Chandri N. Yandava, George T. De Sanctis, Paul L. Huang, Lester Kobzik
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 273:L883-L888
Nitric oxide (NO) can be measured in the expired gas of humans and animals, but the source of expired NO (FENO) and the functional contribution of the various known isoforms of NO synthase (NOS) to the NO measured in the expired air is not known. FEN