Zobrazeno 1 - 10
of 48
pro vyhledávání: '"George T, Shubeita"'
Publikováno v:
Entropy, Vol 23, Iss 9, p 1166 (2021)
Living cells are complex systems characterized by fluids crowded by hundreds of different elements, including, in particular, a high density of polymers. They are an excellent and challenging laboratory to study exotic emerging physical phenomena, wh
Externí odkaz:
https://doaj.org/article/60fb337578954e4dacc2920b56097487
Autor:
Ibtissem Nabti, Babu J. N. Reddy, Rachid Rezgui, Wenqi Wang, Steven P. Gross, George T. Shubeita
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Regulation of organelle transport by molecular motors along the cytoskeletal microtubules is central to maintaining cellular functions. Here, we show that the ubiquitous tau-related microtubule-associated protein 4 (MAP4) can bias the bidirectional t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99059ebc082f98bd152c1e35ad207e64
https://doi.org/10.1073/pnas.2206677119
https://doi.org/10.1073/pnas.2206677119
Autor:
Ibtissem Nabti, George T. Shubeita, Fatima S M Refai, Yanthe E. Pearson, Xin Xie, C.U. Murade, Kristin C. Gunsalus, Samata Chaudhuri, Hala Fahs
Publikováno v:
ACS Sensors. 6:2233-2240
Molecules that bind DNA by intercalating its bases remain among the most potent cancer therapies and antimicrobials due to their interference with DNA-processing proteins. To accelerate the discovery of novel intercalating drugs, we designed a fluore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10bb6c201df57544401ed9ff51bd8edd
https://doi.org/10.1021/acssensors.1c00167
https://doi.org/10.1021/acssensors.1c00167
Autor:
Guilherme Nettesheim, Gabriel R. Jaffe, C.U. Murade, George T. Shubeita, Ibtissem Nabti, Stephen J. King
Publikováno v:
Nature Physics. 16:1144-1151
Eukaryotic cell processes depend on molecular motors to transport cargo along cytoskeletal filaments, and the response of these mechanoenzymes to external forces shapes their cellular function. These responses have been largely mapped out in dilute,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98584cb777847bb285a9fdf28cbe3cda
https://doi.org/10.1038/s41567-020-0957-y
https://doi.org/10.1038/s41567-020-0957-y
Publikováno v:
Imaging and Applied Optics Congress 2022 (3D, AOA, COSI, ISA, pcAOP).
DNA-ligand interactions are dominated by electrostatics as DNA is a highly charged molecule at physiological conditions. Here, we present a FRET-based sensor which can optically report on these interactions between DNA and charged ligands.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bbeb7597099e2a6394b082f1a7c3b95
https://doi.org/10.1364/3d.2022.jw5d.5
https://doi.org/10.1364/3d.2022.jw5d.5
Autor:
Ibtissem Nabti, Babu Reddy Janakaloti Narayanareddy, Rachid Rezgui, Wenqi Wang, Steven Gross, George T. Shubeita
Publikováno v:
Biophysical Journal. 122:26a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3cc00ddbe721d27b31ae280c3c4e5e4
https://doi.org/10.1016/j.bpj.2022.11.361
https://doi.org/10.1016/j.bpj.2022.11.361
Autor:
George T. Shubeita, C.U. Murade
Publikováno v:
Biomed Opt Express
Among the various types of interactions between biomolecules, electrostatic interactions dominate as these are long-range interactions and are often a generic first step in the recruitment of specific ligands. DNA, being a highly charged molecule, at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abae5f65c81a942f944bc2a8192a245b
https://pubmed.ncbi.nlm.nih.gov/35154861
https://pubmed.ncbi.nlm.nih.gov/35154861
Autor:
Chandrashekhar U, Murade, Samata, Chaudhuri, Ibtissem, Nabti, Hala, Fahs, Fatima S M, Refai, Xin, Xie, Yanthe E, Pearson, Kristin C, Gunsalus, George T, Shubeita
Publikováno v:
ACS sensors. 6(6)
Molecules that bind DNA by intercalating its bases remain among the most potent cancer therapies and antimicrobials due to their interference with DNA-processing proteins. To accelerate the discovery of novel intercalating drugs, we designed a fluore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab14560dacddb535d3635f43433a80a7
https://pubmed.ncbi.nlm.nih.gov/34029461
https://pubmed.ncbi.nlm.nih.gov/34029461
Autor:
Rafael A Longoria, George T Shubeita
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67710 (2013)
To complete meiosis II in animal cells, the male DNA material needs to meet the female DNA material contained in the female pronucleus at the egg center, but it is not known how the male pronucleus, deposited by the sperm at the periphery of the cell
Externí odkaz:
https://doaj.org/article/505aef3cb17643f5b58da2ca3e8251d8
Autor:
Ibtissem Nabita, C.U. Murade, George T. Shubeita, Samata Chadhuri, Kris Gunsalus, Fathima Shaffra Refai, Hala Fahs
Publikováno v:
Biophysical Journal. 118:315a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf4efe508248cc43327a28a52a0f752c
https://doi.org/10.1016/j.bpj.2019.11.1772
https://doi.org/10.1016/j.bpj.2019.11.1772