Zobrazeno 1 - 7
of 7
pro vyhledávání: '"George Sutphin"'
Autor:
Undine Kruegel, Brett Robison, Thomas Dange, Günther Kahlert, Joe R Delaney, Soumya Kotireddy, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Christopher J Murakami, Jennifer Schleit, George Sutphin, Daniel Carr, Krisztina Tar, Gunnar Dittmar, Matt Kaeberlein, Brian K Kennedy, Marion Schmidt
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002253 (2011)
Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component employed by cells to counter toxic protein aggregates is the conserved ubiquitin/proteasome syste
Externí odkaz:
https://doaj.org/article/cb26d1c7f14d4479b9b28b8bfe0b4d0f
Publikováno v:
Innovation in Aging. 6:730-731
Metabolism of tryptophan by the kynurenine pathway is increasingly linked to aging. Kynurenine pathway enzymes and metabolites influence a range of molecular processes critical to healthy aging, including regulation of inflammatory and immune respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c6be1a552c7894474f467c3731e400a
https://doi.org/10.1093/geroni/igac059.2662
https://doi.org/10.1093/geroni/igac059.2662
Autor:
Luis Espejo, Destiny DeNicola, Sam Freitas, Hope Dang, Emily Turner, Raul Castro-Portuguez, Anne Haskins, George Sutphin
Publikováno v:
Innovation in Aging. 5:674-675
Select kynurenine pathway interventions extend lifespan in invertebrate models and are of interest in treating age-associated diseases. Kynurenine pathway activity is responsive to inflammatory signaling, and we are evaluating the potential for these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8457f4d2974735a557b714518227a9d5
https://doi.org/10.1093/geroni/igab046.2541
https://doi.org/10.1093/geroni/igab046.2541
Publikováno v:
Innovation in Aging
Cancer cells have elevated energy demands to sustain continuous growth and other malignant processes and undergo extensive metabolic reprogramming to meet these demands. One element of this reprogramming in many cancer subtypes is elevated synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30886785f858b7ee07c241efb5e94a4
http://europepmc.org/articles/PMC8681161
http://europepmc.org/articles/PMC8681161
Autor:
George Sutphin, Hope Dang, Luis Espejo, Raul Castro-Portuguez, Bradford Hull, Jeremy Meyers, Emily Turner, Destiny DeNicola
Publikováno v:
Innovation in Aging
Aberrant kynurenine pathway metabolism is increasingly linked to aging and age-associated disease. Kynurenine metabolic activity increases with age and becomes dysregulated during various forms of age-associated pathology in humans. By manipulating o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b98194a28abef5315b36cd7c730a2c
http://europepmc.org/articles/PMC8680976
http://europepmc.org/articles/PMC8680976
Autor:
Bradford Hull, George Sutphin
Publikováno v:
Innovation in Aging
Cellular stress is a fundamental component of age-associated disease. Cells experience many forms of stress (oxidative, heavy metal, etc.), and as we age the burden of stress and resulting damage increases while our cells’ ability to deal with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdf67ad9c86b9e79f237b0f71dab0e4
http://europepmc.org/articles/PMC8681331
http://europepmc.org/articles/PMC8681331
Publikováno v:
Innovation in Aging. 5:682-682
Cellular stress is an ever-present aspect of aging and a primary driver of many common age-associated diseases such as cancer, diabetes, or neurodegenerative diseases. As we age, stress-induced damage accumulates over time, along with reduced efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aac26c6ab23d577044507578ae193fdc
https://doi.org/10.1093/geroni/igab046.2566
https://doi.org/10.1093/geroni/igab046.2566