Zobrazeno 1 - 10
of 24
pro vyhledávání: '"George Stepan"'
Autor:
Datsen George Wei, Vicki Chiang, Elizabeth Fyne, Mini Balakrishnan, Tiffany Barnes, Michael Graupe, Joseph Hesselgesser, Alivelu Irrinki, Jeffrey P Murry, George Stepan, Kirsten M Stray, Angela Tsai, Helen Yu, Jonathan Spindler, Mary Kearney, Celsa A Spina, Deborah McMahon, Jacob Lalezari, Derek Sloan, John Mellors, Romas Geleziunas, Tomas Cihlar
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004071 (2014)
Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a major obstacle to curing HIV infection. Pharmacological activation of HIV expression in latently infected cells is being explored as one of the strategies to d
Externí odkaz:
https://doaj.org/article/ac65303f63b846a6ab208ba464922569
Autor:
Ladislav Prener, Ondřej Baszczyňski, Martin M. Kaiser, Martin Dračínský, George Stepan, Yu-Jen Lee, Boris Brumshtein, Helen Yu, Petr Jansa, Eric B. Lansdon, Zlatko Janeba
Publikováno v:
Journal of Medicinal Chemistry. 66:1761-1777
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39ab39534a1970a487d788dabe69090c
https://doi.org/10.1021/acs.jmedchem.2c01574
https://doi.org/10.1021/acs.jmedchem.2c01574
Autor:
Qi Liu, Chien-Hung Chou, Eda Canales, Roman Sakowicz, Steven Bondy, Tomas Cihlar, Albert Liclican, Diana M. Brainard, Anita Niedziela-Majka, William Rowe, Nikolai Novikov, Shekeba Ahmadyar, John R. Somoza, Randall L. Halcomb, Cheryl K. McDonald, Carina E. Cannizzaro, Nicolas Margot, Debi Jin, George Stepan, Qiaoyin Wu, Eric Hu, Judy Mwangi, Stephanie A. Leavitt, Todd C. Appleby, Robert L. Anderson, Scott E. Lazerwith, Schroeder Scott D, Tse Winston C, Gediminas Brizgys, Rebecca Begley, Yili Xu, Scott Sellers, Scott A. Wolckenhauer, Wesley I. Sundquist, Derek Hansen, Philip Morganelli, Andrew Mulato, Sheila Clancy, Xiaohong Liu, Anna Chiu, Eric S. Daar, Renee R. Ram, S. Swaminathan, Anne E. Chester, Melanie H. Wong, Ya-Pei Liu, John O. Link, Michael Graupe, Luong K. Tsai, Christian Callebaut, Latesh Lad, William E. Lee, Rujuta A. Bam, Terrence Z. Cai, Bing Lu, John K. Ling, Roland D. Saito, Magdeleine Hung, Armando G. Villaseñor, Peter Ruane, Nikos Pagratis, Martin S. Rhee, David Koditek, Gordon Crofoot, Giuseppe A. Papalia, Stephen R. Yant, Rob Hyland, Helen Yu, Jim Zheng, Jennifer R. Zhang, Gary I. Sinclair, Jiayao Li, Eric Singer
Publikováno v:
Nature
Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1–5. However, some people living with HIV who are heavily treatment-experienced have limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5892a90808b40581a09439f9529aaaa6
https://doi.org/10.1038/s41586-020-2443-1
https://doi.org/10.1038/s41586-020-2443-1
Autor:
Melanie H. Wong, Helen Yu, Daniel Gonik, Derek Hansen, Wesley I. Sundquist, Debi Jin, Anita Niedziela-Majka, Nikolai Novikov, William M. McDougall, Shekeba Ahmadyar, Albert Liclican, Jill M. Perreira, Andrew Mulato, George Stepan, Jennifer R. Zhang, Bing Lu, Magdeleine Hung, Giuseppe A. Papalia, Renee R. Ram, John O. Link, Kevin Chou, Abraham L. Brass, Eric E. Paoli, Stephen R. Yant, Jim Zheng, Eric Singer, Eric Hu, Tomas Cihlar, Schroeder Scott D, Tse Winston C
Publikováno v:
Nat Med
People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication fatigue that might lead to suboptimal treatment adherence and the emergence of drug-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283229e5414364737d5a0814370ed2fa
https://doi.org/10.1038/s41591-019-0560-x
https://doi.org/10.1038/s41591-019-0560-x
Publikováno v:
eLife, Vol 12 (2024)
Untargeted metabolomic profiling through liquid chromatography-mass spectrometry (LC-MS) measures a vast array of metabolites within biospecimens, advancing drug development, disease diagnosis, and risk prediction. However, the low throughput of LC-M
Externí odkaz:
https://doaj.org/article/30115f1a58ce442db8f042d039efe2b2
Autor:
Roy Bannister, George Stepan, Yili Xu, Roman Sakowicz, Michel Perron, Ona Barauskas, Eisuke Murakami, Cynthia Kim, Tomas Cihlar, Brian E. Schultz, Dmytro Kornyeyev, Gary Lee, Danielle P. Porter, Joy Y. Feng, Darius Babusis
Publikováno v:
Antimicrobial Agents and Chemotherapy
Remdesivir (RDV, GS-5734), the first FDA-approved antiviral for the treatment of COVID-19, is a single diastereomer monophosphoramidate prodrug of an adenosine analogue. It is intracellularly metabolized into the active triphosphate form, which in tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e35e6af2becb2fd0246022ee451bdc
https://doi.org/10.1128/aac.02237-20
https://doi.org/10.1128/aac.02237-20
Publikováno v:
Physical Review Research, Vol 6, Iss 4, p 043062 (2024)
Despite rapid progress in data acquisition techniques, many complex physical, chemical, and biological systems remain only partially observable, thus posing the challenge to identify valid theoretical models and estimate their parameters from an inco
Externí odkaz:
https://doaj.org/article/5084f6e0b0054d17aabf72dff2279977
Autor:
Jean-Yves Christophe Chiva, Peter Pyun, Andrew John Keats, Linos Lazarides, Karine G. Poullennec, Neil Andrew Dunbar, Brian E. Schultz, Mingzhe Ji, Gregory M. Watt, Karki Kapil Kumar, Ruby Cai, Carina E. Cannizzaro, Uli Schmitz, David Kenneth Dean, Yu-Jen Lee, Sangi Michael, Victoria Alexandra Steadman, Adam J. Schrier, Simon B. Pettit, Hans G. Fliri, Adrian John Highton, Todd C. Appleby, Carol Austin, Richard L. Mackman, Caroline A. Blakemore, Hui Hon Chung, Dustin Siegel, Gregory Chin, Bernard P. Murray, Hai Yang, Yang Tian, George Stepan, Jonathan Sanvoisin, Albert Liclican, Mish Michael R, David Sperandio, Rex Santos, Petr Jansa, Haolun Jin
Publikováno v:
Journal of Medicinal Chemistry. 61:9473-9499
Cyclophilins are a family of peptidyl-prolyl isomerases that are implicated in a wide range of diseases including hepatitis C. Our aim was to discover through total synthesis an orally bioavailable, non-immunosuppressive cyclophilin (Cyp) inhibitor w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f349698a38c7c9924d318620a6fcc5d2
https://doi.org/10.1021/acs.jmedchem.8b00802
https://doi.org/10.1021/acs.jmedchem.8b00802
Autor:
Tomas Cihlar, Kirsten L. White, Danielle P. Porter, Derek Hansen, Alexander Thielen, Martin Daeumer, Stephen R. Yant, George Stepan, Andrew Mulato
Publikováno v:
AIDS Research and Human Retroviruses. 32:1237-1247
Failure of combination antiretroviral (ARV) therapy in HIV-infected patients is often associated with the emergence of drug resistance-associated mutations (RAMs). To facilitate analysis of the barrier to resistance at therapeutically relevant ARV co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0760c45171d2e627b7bb32b11904a211
https://doi.org/10.1089/aid.2016.0071
https://doi.org/10.1089/aid.2016.0071
Autor:
David Šaman, Petr Jansa, George Stepan, Milan Dejmek, Ondřej Baszczyňski, Petr Šimon, Zlatko Janeba, Eric Hu, Liping Gao, Lucie Čechová
Publikováno v:
Antiviral Chemistry & Chemotherapy
Antiviral Chemistry & Chemotherapy, Vol 27 (2019)
Antiviral Chemistry & Chemotherapy, Vol 27 (2019)
With the worldwide number of human immunodeficiency virus positive patients stagnant and the increasing emergence of viral strains resistant to current treatment, the development of novel anti-human immunodeficiency virus drug candidates is a perpetu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f714fc186c6b532e8eebac161a1332f2
http://europepmc.org/articles/PMC6376552
http://europepmc.org/articles/PMC6376552