Zobrazeno 1 - 10
of 22
pro vyhledávání: '"George Stavrakis"'
Autor:
C. Touramanis, Adam Roberts, Barnaby Philippou, J. Vann, K. Mavrokoridis, Dan Hollywood, Krish Majumdar, Nigel A. Smith, Samuel Powell, George Stavrakis, Kevin J. McCormick
Publikováno v:
Proceedings of The 21st international workshop on neutrinos from accelerators — PoS(NuFact2019)
ARIADNE is a 1-ton dual-phase Time Projection Chamber (TPC) with a novel optical readout. The secondary scintillation light produced in the holes of a THick Gas Electron Multiplier (THGEM) is captured by Electron Multiplying Charge Coupled Device (EM
Autor:
Bruce H. Horwitz, Guillermo García-Cardeña, Xavier Cullere, Yuzhi Zhang, Francis W. Luscinskas, Thomas Ernandez, Deepak Venkatesh, Ibrahim Batal, George Stavrakis, Tanya N. Mayadas, Florencia Rosetti
Publikováno v:
Immunity. 38:1025-1037
SummaryEndothelial-dependent mechanisms of mononuclear cell influx are not well understood. We showed that acute stimulation of murine microvascular endothelial cells expressing the tumor necrosis factor receptors TNFR1 and TNFR2 with the soluble cyt
Autor:
Diana Gómez-Martín, Sanjeev Sethi, Nico van Rooijen, Hiroshi Nishi, Kevin Croce, Andrew H. Lichtman, Thomas Ernandez, George C. Tsokos, Naotake Tsuboi, Vasileios C. Kyttaris, Tanya N. Mayadas, Florencia Rosetti, George Stavrakis, Jorge Alcocer-Varela, Kan Chen
Publikováno v:
Journal of Immunology, 189(7), 3714-3723. American Association of Immunologists
Rosetti, F, Tsuboi, N, Chen, K, Nishi, H, Ernandez, T, Sethi, S, Croce, K, Stavrakis, G, Alcocer-Varela, J, Gomez-Martin, D, van Rooijen, N, Kyttaris, V C, Lichtman, A H, Tsokos, G C & Mayadas, T N 2012, ' Human Lupus Serum Induces Neutrophil-Mediated Organ Damage in Mice That Is Enabled by Mac-1 Deficiency ', Journal of Immunology, vol. 189, no. 7, pp. 3714-3723 . https://doi.org/10.4049/jimmunol.1201594
Rosetti, F, Tsuboi, N, Chen, K, Nishi, H, Ernandez, T, Sethi, S, Croce, K, Stavrakis, G, Alcocer-Varela, J, Gomez-Martin, D, van Rooijen, N, Kyttaris, V C, Lichtman, A H, Tsokos, G C & Mayadas, T N 2012, ' Human Lupus Serum Induces Neutrophil-Mediated Organ Damage in Mice That Is Enabled by Mac-1 Deficiency ', Journal of Immunology, vol. 189, no. 7, pp. 3714-3723 . https://doi.org/10.4049/jimmunol.1201594
Systemic lupus erythematosus (SLE) is a chronic, multiorgan inflammatory autoimmune disorder associated with high levels of circulating autoantibodies and immune complexes. We report that passive transfer of human SLE sera into mice expressing the un
Autor:
Arlene H. Sharpe, Gordon J. Freeman, Goro Tajima, James A. Lederer, De-xiu Bu, Andrew H. Lichtman, Margarite L. Tarrio, Elena Maganto-Garcia, Petr Jarolim, George Stavrakis
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:1100-1107
Objective— Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers negative signals on interaction with its 2 ligands, PD-L1 and PD-L2. We studied the contribution of the PD-1 pathway to regulation of T cells that promote a
Autor:
Yuzhi Zhang, Hiroyuki Yamazaki, Guillermo García-Cardeña, Zachary A. Pepper-Cunningham, Andrew H. Lichtman, Petr Jarolim, Masanori Aikawa, Elena Maganto-Garcia, George Stavrakis, Nir Grabie, De-xiu Bu, Margarite L. Tarrio
Publikováno v:
Journal of Clinical Investigation. 120:1961-1970
The transcription factor Krüppel-like factor 2 (KLF2) is required for the quiescent and migratory properties of naive T cells. Statins, a class of HMG-CoA reductase inhibitors, display pleiotropic immunomodulatory effects that are independent of the
Autor:
Toshiro Fujita, Tatsuo Shimosawa, Yunmei Wang, Shinya Kaname, Junichi Hirahashi, Kazuo Suzuki, Daniel I. Simon, Keiichi Hishikawa, Yutaka Nagahama, Tanya N. Mayadas, George Stavrakis, Ling Xiao, Naotake Tsuboi
Publikováno v:
Circulation. 120:1255-1265
Background— Inflammation and thrombosis coexist in several disorders. Although it is recognized that leukocytes may induce a procoagulant state at sites of inflammation, the critical molecular determinants of this process remain largely unknown. Me
Autor:
Rosa DaCosta, Hong Pang, Nir Grabie, Gordon J. Freeman, Israel Gotsman, Arlene H. Sharpe, George Stavrakis, Andrew H. Lichtman, Manish J. Butte, Mary E. Keir
Publikováno v:
Circulation. 116:2062-2071
Background—PD-L1 and PD-L2 are ligands for the inhibitory receptor programmed death-1 (PD-1), which is an important regulator of immune responses. PD-L1 is induced on cardiac endothelial cells under inflammatory conditions, but little is known abou
Autor:
Andrew H. Lichtman, George Stavrakis, Paurene Duramad, Victoria A. Love, Nir Grabie, Arlene H. Sharpe
Publikováno v:
Circulation Research. 101:248-257
CD8+cytotoxic T lymphocytes contribute to viral and autoimmune myocarditis and cardiac allograft rejection. The role of cytotoxic T-lymphocyte–associated antigen (CTLA)-4 as a negative regulator of CD4+T cells is well defined, yet CTLA-4 regulation
Autor:
George Stavrakis, Sara Knight, Ling Xiao, Ulrich H. von Andrian, Peter E. O'Donnell, Tracy Stokol, Tanya N. Mayadas, Marina Botto
Publikováno v:
The Journal of Experimental Medicine
Inflammation induced by circulating immunoglobulin G–immune complexes (ICs) characterizes many immune-mediated diseases. In this work, the molecular requirements for the deposition of circulating ICs and subsequent acute leukocyte recruitment in mi
Autor:
Michael A. Gimbrone, Masaya Takahas, M. Judah Folkman, Stephanie Kwei, George A. Taylor, George Stavrakis, Guillermo García-Cardeña
Publikováno v:
The American Journal of Pathology. 164:81-89
Venous arterialization occurs when a vein segment is transposed as a bypass graft into the arterial circulation, resulting in a structural and functional reorganization of the vascular wall in response to the new local biomechanical environment. Alth