Clinical Effects of the Self-administered Subcutaneous Complement Inhibitor Zilucoplan in Patients With Moderate to Severe Generalized Myasthenia Gravis: Results of a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial

Autor: James F, Howard, Richard J, Nowak, Gil I, Wolfe, Miriam L, Freimer, Tuan H, Vu, John L, Hinton, Michael, Benatar, Petra W, Duda, James E, MacDougall, Ramin, Farzaneh-Far, Henry J, Kaminski, Richard, Barohn, Mazen, Dimachkie, Mamatha, Pasnoor, Constantine, Farmakidis, Tina, Liu, Samantha, Colgan, Michael G, Benatar, Tulio, Bertorini, Rekha, Pillai, Robert, Henegar, Mark, Bromberg, Summer, Gibson, Teresa, Janecki, Miriam, Freimer, Bakri, Elsheikh, Paige, Matisak, Angela, Genge, Amanda, Guidon, William, David, Ali A, Habib, Veena, Mathew, Tahseen, Mozaffar, William, Hewitt, Deborah, Barnett, Patricia, Sullivan, Doreen, Ho, Rebecca E, Traub, Manisha, Chopra, Radwa, Aly, Elham, Bayat, Mohammad, Abu-Rub, Shaida, Khan, Dale, Lange, Shara, Holzberg, Bhupendra, Khatri, Emily, Lindman, Tayo, Olapo, Lisa M, Sershon, Robert P, Lisak, Evanthia, Bernitsas, Kelly, Jia, Rabia, Malik, Tiffany D, Lewis-Collins, Michael, Nicolle, Aditi, Sharma, Bhaskar, Roy, Joan, Nye, Michael, Pulley, Alan, Berger, Yasmeen, Shabbir, Amit, Sachdev, Kimberly, Patterson, Zaeem, Siddiqi, Mark, Sivak, Joan, Bratton, George, Small, Anem, Kohli, Mary, Fetter, Tuan, Vu, Lucy, Lam, Brittany, Harvey, Nicholas, Silvestri, Kara, Patrick, Karen, Zakalik, James, MacDougall, Angela, Pontius, Michelle, Hoarty

Publikováno v: JAMA neurology. 77(5)

Importance Many patients with generalized myasthenia gravis (gMG) have substantial clinical disability, persistent disease burden, and adverse effects attributable to chronic immunosuppression. Therefore, there is a significant need for targeted, wel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eeb0f9a4554ca1cd6226b2f14501b70
https://pubmed.ncbi.nlm.nih.gov/32065623

Isolated laryngeal myokymia: diagnosis and treatment

Autor: Clark A. Rosen, Melissa M. Statham, George Small, Michael C. Munin, Jacob Sedgh

Publikováno v: The Laryngoscope. 120(10)

Myokymia is an uncommon neuromuscular disorder that rarely affects the human larynx. No previous reports of isolated laryngeal myokymia are present in the literature, and as such, established treatment protocols are lacking. We report the first case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4060a260436c242a2fd5e148bb8c2689
https://pubmed.ncbi.nlm.nih.gov/20683936

Co-existing inflammatory bowel disease and Barrett’s esophagus is associated with esophageal dysplasia: a propensity score-matched cohort

Autor: Matthew Fasullo, Aditya Sreenivasen, Erik Holzwanger, Charles Lavender, Milan Patel, Tilak Shah, Pritesh Mutha, Robert F. Yacavone, Keith Sultan, Arvind J. Trindade, George Smallfield

Publikováno v: Endoscopy International Open, Vol 09, Iss 10, Pp E1524-E1529 (2021)

Background and study aims Barrettʼs esophagus (BE) and inflammatory bowel disease (IBD) predispose to the development of dysplasia and cancer. It is unclear if the inflammatory cascade seen in IBD affects disease progression in BE. We aimed to deter

Externí odkaz: https://doaj.org/article/0c7ecdaf1cd84931a22e346f3dd4d243

Full-thickness resection device (FTRD) for treatment of upper gastrointestinal tract lesions: the first international experience

Autor: Kaveh Hajifathalian, Yervant Ichkhanian, Qais Dawod, Alexander Meining, Arthur Schmidt, Nicholas Glaser, Kia Vosoughi, David L. Diehl, Ian S. Grimm, Theodore James, Adam W. Templeton, Jason B. Samarasena, Nabil El Hage Chehade, John G. Lee, Kenneth J. Chang, Meir Mizrahi, Mohammed Barawi, Shayan Irani, Shai Friedland, Paul Korc, Abdul Aziz Aadam, Mohammad Al-Haddad, Thomas E. Kowalski, George Smallfield, Gregory G. Ginsberg, Norio Fukami, Michael Lajin, Nikhil A. Kumta, Shou-jiang Tang, Yehia Naga, Stuart K. Amateau, Franklin Kasmin, Martin Goetz, Stefan Seewald, Vivek Kumbhari, Saowanee Ngamruengphong, Srihari Mahdev, Saurabh Mukewar, Kartik Sampath, David L. Carr-Locke, Mouen A. Khashab, Reem Z. Sharaiha

Publikováno v: Endoscopy International Open, Vol 08, Iss 10, Pp E1291-E1301 (2020)

Background and study aims The Full-Thickness Resection Device (FTRD) provides a novel treatment option for lesions not amenable to conventional endoscopic resection techniques. There are limited data on the efficacy and safety of FTRD for resection o

Externí odkaz: https://doaj.org/article/b8a7e939c22149a4b48838ba1f3b3402