Zobrazeno 1 - 10
of 11
pro vyhledávání: '"George Skalka"'
Autor:
Declan Whyte, George Skalka, Peter Walsh, Ania Wilczynska, Nikki R. Paul, Claire Mitchell, Colin Nixon, William Clarke, Martin Bushell, Jennifer P. Morton, Daniel J. Murphy, Nathiya Muthalagu
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1212-1227 (2023)
The AMP‐activated protein kinase (AMPK)‐related kinase NUAK1 (NUAK family SNF1‐like kinase 1) has emerged as a potential vulnerability in MYC‐dependent cancer but the biological roles of NUAK1 in different settings are poorly characterised, a
Externí odkaz:
https://doaj.org/article/6896303684144ae5bf0d4de609aa31de
Autor:
Andrew Craxton, Deeksha Munnur, Rebekah Jukes-Jones, George Skalka, Claudia Langlais, Kelvin Cain, Michal Malewicz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
PAXX functions as part of the nonhomologous end-joining pathway to repair double-strand DNA breaks. Here the authors show PAXX and its paralogs interact with polymerase lambda to promote joining of incompatible ends.
Externí odkaz:
https://doaj.org/article/9c0730c851de40b5b3372bd7dc7822b1
Autor:
Deeksha Munnur, Joanna Somers, George Skalka, Ria Weston, Rebekah Jukes-Jones, Mohammed Bhogadia, Cyril Dominguez, Kelvin Cain, Ivan Ahel, Michal Malewicz
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2028-2036.e6 (2019)
Summary: Although poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood. NR4A nuclear orphan receptors were previously linked to DSB repair; h
Externí odkaz:
https://doaj.org/article/fdedb83939404dee9e65c1e7a9fcb645
Autor:
Declan Whyte, George Skalka, Peter Walsh, Ania Wilczynska, Nikki R. Paul, Claire Mitchell, Colin Nixon, William Clarke, Martin Bushell, Jennifer P. Morton, Daniel J. Murphy, Nathiya Muthalagu
Publikováno v:
Molecular Oncology.
Autor:
null Declan Whyte, null George Skalka, null Peter Walsh, null Ania Wilczynska, null Nikki R. Paul, null Claire Mitchell, null Colin Nixon, null William Clarke, null Martin Bushell, null Jennifer P. Morton, null Daniel J. Murphy, null Nathiya Muthalagu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef763b43e6d10b3ea0a7ccd567b72841
https://doi.org/10.1002/1878-0261.13425/v2/response1
https://doi.org/10.1002/1878-0261.13425/v2/response1
Autor:
Janna Luessing, Aldo S. Bader, Wei-Ting Lu, George Skalka, Ben R Hawley, Noel F. Lowndes, Martin Bushell
Proteins with RNA-binding activity are increasingly being implicated in DNA damage responses (DDR). Additionally, DNA:RNA-hybrids are rapidly generated around DNA double-strand breaks (DSBs), and are essential for effective repair. Here, using a meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b78dc5f1a2054e8607f798b77c459c1
https://www.repository.cam.ac.uk/handle/1810/344182
https://www.repository.cam.ac.uk/handle/1810/344182
Autor:
Anne E. Willis, Laura McDonald, George Skalka, Andrew D. Campbell, Heather McKinnon, Kevin M. Haigis, John R. P. Knight, Sebastian May-Wilson, Kathryn Gilroy, William J. Faller, Emma Stanway, Leah Officer, Rachael C. L. Smith, Joshua D.G. Leach, Joseph A. Waldron, Rachel A. Ridgway, Nicola Valeri, Ewan M. Smith, Arafath Kaja Najumudeen, Nahum Sonenberg, Joanne Edwards, Rene Jackstadt, Ana Teodósio, John Le Quesne, Dustin J. Flanagan, Anne Cheasty, Georgios Kanellos, Kerri McArthur, Christopher G. Proud, Constantinos Alexandrou, Georgios Vlachogiannis, Neil P. Jones, Nikola Vlahov, Owen J. Sansom, Kathryn Af Pennel, Craig MacKay, Martin E. Swarbrick, Martin Bushell
Publikováno v:
Knight, J R P, Alexandrou, C, Skalka, G L, Vlahov, N, Pennel, K, Officer, L, Teodosio, A, Kanellos, G, Gay, D M, May-Wilson, S, Smith, E M, Najumudeen, A K, Gilroy, K, Ridgway, R A, Flanagan, D J, Smith, R C L, McDonald, L, MacKay, C, Cheasty, A, McArthur, K, Stanway, E, Leach, J D, Jackstadt, R, Waldron, J A, Campbell, A D, Vlachogiannis, G, Valeri, N, Haigis, K M, Sonenberg, N, Proud, C G, Jones, N P, Swarbrick, M E, McKinnon, H J, Faller, W J, Quesne, J L, Edwards, J, Willis, A E, Bushell, M & Sansom, O J 2021, ' MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression ', Cancer discovery, vol. 11, no. 5, pp. 1228-1247 . https://doi.org/10.1158/2159-8290.CD-20-0652
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b093ca20383c7ab94bac414895dbf3
https://doi.org/10.1158/2159-8290.CD-20-0652
https://doi.org/10.1158/2159-8290.CD-20-0652
Publikováno v:
Cell Cycle
Common hallmarks of cancer include the dysregulation of cell cycle progression and the acquisition of genome instability. In tumors, G1 cell cycle checkpoint induction is often lost. This increases the reliance on a functional G2/M checkpoint to prev
Autor:
Cyril Dominguez, Deeksha Munnur, Michal Malewicz, Rebekah Jukes-Jones, Ivan Ahel, George Skalka, Kelvin Cain, Mohammed Bhogadia, Joanna Somers, Ria Weston
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2028-2036.e6 (2019)
Cell Reports
Cell Reports
Summary Although poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood. NR4A nuclear orphan receptors were previously linked to DSB repair; ho
Autor:
Ana Sofia Rocha, Owen J. Sansom, Callum R Livingstone, Thomas M Drake, Miryam Mueller, Thomas G. Bird, George Skalka, Stephanie May, Colin Nixon, Ann Hedley, Christos Kiourtis, William C. Clark, Robin M. Shaw
/IntroductionUnderstanding how the liver regenerates is a key biological question. Hepatocytes are the principle regenerative population in the liver. Recently, numerous lineage tracing studies (which apply genetic tagging to a restricted population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e4d6e46c50723358540acf4c666f55f
https://doi.org/10.1101/2020.12.09.405936
https://doi.org/10.1101/2020.12.09.405936