Zobrazeno 1 - 10
of 31
pro vyhledávání: '"George Sflomos"'
Autor:
Tatjana Geukens, Maxim De Schepper, Wouter Van Den Bogaert, Karen Van Baelen, Marion Maetens, Anirudh Pabba, Amena Mahdami, Sophia Leduc, Edoardo Isnaldi, Ha-Linh Nguyen, Imane Bachir, Maysam Hajipirloo, Gitte Zels, Josephine Van Cauwenberge, Kristien Borremans, Vincent Vandecaveye, Birgit Weynand, Peter Vermeulen, Eleonora Leucci, Maria Francesca Baietti, George Sflomos, Laura Battista, Cathrin Brisken, Patrick W. B. Derksen, Thijs Koorman, Daan Visser, Colinda L. G. J. Scheele, Daniela S. Thommen, Sigrid Hatse, Sarah-Maria Fendt, Evy Vanderheyden, Thomas Van Brussel, Rogier Schepers, Bram Boeckx, Diether Lambrechts, Giuseppe Marano, Elia Biganzoli, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Hans Wildiers, François Richard, Giuseppe Floris, Christine Desmedt
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) metastases and 5-8
Externí odkaz:
https://doaj.org/article/64acb1b4e34a40a5a3f7576042fa573b
Autor:
Patrick Aouad, Yueyun Zhang, Fabio De Martino, Céline Stibolt, Simak Ali, Giovanna Ambrosini, Sendurai A. Mani, Kelly Maggs, Hazel M. Quinn, George Sflomos, Cathrin Brisken
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The study of tumour dormancy is limited by suitable in vivo models. Here the authors show that mammary intraductal breast cancer (BC) xenografts model estrogen receptor α-positive (ER+) BC dormancy and rapid metastatic progression characteristic of
Externí odkaz:
https://doaj.org/article/e64c8d7c36a048a5972caf859a65088a
Autor:
Valentina Scabia, Ayyakkannu Ayyanan, Fabio De Martino, Andrea Agnoletto, Laura Battista, Csaba Laszlo, Assia Treboux, Khalil Zaman, Athina Stravodimou, Didier Jallut, Maryse Fiche, Philip Bucher, Giovanna Ambrosini, George Sflomos, Cathrin Brisken
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The role of progesterone receptor (PR) and its interplay with estrogen receptor (ER) in breast cancer is controversial. Here, the authors demonstrate that PR can have an ER-independent role in breast cancer growth and metastasis and that its effects
Externí odkaz:
https://doaj.org/article/e90383a7e88449f6abdfb06422e18297
Autor:
George Sflomos, Nora Schaumann, Matthias Christgen, Henriette Christgen, Stephan Bartels, Hans Kreipe, Laura Battista, Cathrin Brisken
Publikováno v:
Cancers, Vol 15, Iss 13, p 3299 (2023)
Invasive lobular carcinoma (ILC) is a common breast cancer subtype that is often diagnosed at advanced stages and causes significant morbidity. Late-onset secondary tumor recurrence affects up to 30% of ILC patients, posing a therapeutic challenge if
Externí odkaz:
https://doaj.org/article/259b6ff613474728a337a07c2f86cbb1
Autor:
Ana Luísa Cartaxo, Marta F. Estrada, Giacomo Domenici, Ruben Roque, Fernanda Silva, Emilio J. Gualda, Pablo Loza-Alvarez, George Sflomos, Cathrin Brisken, Paula M. Alves, Saudade André, Catarina Brito
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-14 (2020)
Abstract Background Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) and, in these case
Externí odkaz:
https://doaj.org/article/fc981856c13b4158bcfc1adff2fdfb38
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1
Autor:
George Sflomos, Laura Battista, Patrick Aouad, Fabio De Martino, Valentina Scabia, Athina Stravodimou, Ayyakkannu Ayyanan, Assia Ifticene‐Treboux, RLS, Philipp Bucher, Maryse Fiche, Giovanna Ambrosini, Cathrin Brisken
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
Abstract Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from other estrogen receptor‐positive (ER+) breast canc
Externí odkaz:
https://doaj.org/article/8496cd22d6914407af3da1471f234dcb
Autor:
Stéphanie Cagnet, Dalya Ataca, George Sflomos, Patrick Aouad, Sonia Schuepbach-Mallepell, Henry Hugues, Andrée Krust, Ayyakkannu Ayyanan, Valentina Scabia, Cathrin Brisken
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Oestrogen receptors α (ERα) are expressed in a subset of mammary epithelial cells. Here, the authors identify cells with low-ERα protein levels and show that distinct cell populations have distinct requirements for the AF1 and AF2 domains of the E
Externí odkaz:
https://doaj.org/article/648ebe25ccab4e248c751792d692bd28
Autor:
Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller, Tobias M Gorges, Manfred Jücker, Jean‐Paul Thiery, Cathrin Brisken, Sabine Riethdorf, Catherine Alix‐Panabières, Klaus Pantel
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
Abstract Functional studies giving insight into the biology of circulating tumor cells (CTCs) remain scarce due to the low frequency of CTCs and lack of appropriate models. Here, we describe the characterization of a novel CTC‐derived breast cancer
Externí odkaz:
https://doaj.org/article/6fcb45740e9c4955a376a11179160a9e
Autor:
George Sflomos, Koen Schipper, Thijs Koorman, Amanda Fitzpatrick, Steffi Oesterreich, Adrian V. Lee, Jos Jonkers, Valerie G. Brunton, Matthias Christgen, Clare Isacke, Patrick W. B. Derksen, Cathrin Brisken
Publikováno v:
Cancers, Vol 13, Iss 21, p 5396 (2021)
Invasive lobular carcinoma (ILC) accounts for up to 15% of all breast cancer (BC) cases and responds well to endocrine treatment when estrogen receptor α-positive (ER+) yet differs in many biological aspects from other ER+ BC subtypes. Up to 30% of
Externí odkaz:
https://doaj.org/article/e9a688d788384c04ad1a7eade81bf161
Autor:
Brisken, George Sflomos, Nora Schaumann, Matthias Christgen, Henriette Christgen, Stephan Bartels, Hans Kreipe, Laura Battista, Cathrin
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3299
Invasive lobular carcinoma (ILC) is a common breast cancer subtype that is often diagnosed at advanced stages and causes significant morbidity. Late-onset secondary tumor recurrence affects up to 30% of ILC patients, posing a therapeutic challenge if