Výsledky vyhledávání - "George S. Worthen"

Akademický článek

Long-term Monocyte Dysfunction after Sepsis in Humanized Mice Is Related to Persisted Activation of Macrophage-Colony Stimulation Factor (M-CSF) and Demethylation of PU.1, and It Can Be Reversed by Blocking M-CSF In Vitro or by Transplanting Naïve Autologous Stem Cells In Vivo

Autor: Krzysztof Laudanski, Natalia Lapko, Mateusz Zawadka, Jacek Polosak, George S. Worthen, Gwenn Danet-Desnoyers, Monika Puzianowska-Kuźnicka

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

The duration of post-sepsis long-term immune suppression is poorly understood. Here, we focused on the role of monocytes (MO) as the pivotal cells for long-term regulation of post-sepsis milieu. Lost ability of MO to adapt is seen in several acute co

Externí odkaz: https://doaj.org/article/fa12137d080145ccbe3fcb261facd607

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Akademický článek

Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates

Autor: Yasmine Issah, Amruta Naik, Soon Y Tang, Kaitlyn Forrest, Thomas G Brooks, Nicholas Lahens, Katherine N Theken, Mara Mermigos, Amita Sehgal, George S Worthen, Garret A FitzGerald, Shaon Sengupta

Publikováno v: eLife, Vol 10 (2021)

Adverse early-life exposures have a lasting negative impact on health. Neonatal hyperoxia that is a risk factor for bronchopulmonary dysplasia confers susceptibility to influenza A virus (IAV) infection later in life. Given our previous findings that

Externí odkaz: https://doaj.org/article/8711544c03ab429194aed378dbce44cd

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Circadian regulation of lung repair and regeneration

Autor: Thomas G Brooks, Elizabeth J. Hennessy, Soumitra Sengupta, Yasmine Issah, George S Worthen, Amita Sehgal, Amruta Naik, Edward E. Morrisey, A. B. Reddy, Kaitlyn Forrest, David B. Frank, Michael Morley, U. Valekunja, Garret A. FitzGerald, Apoorva Babu, Gregory R. Grant

Optimal lung repair and regeneration is essential for recovery from viral infections such as that induced by influenza A virus (IAV). We have previously demonstrated that lung inflammation induced by IAV is under circadian control. However, it is not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44e64251a5770f8001709db2cecc04ae
https://doi.org/10.1101/2021.11.20.469376

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Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice

Autor: Juan He, Erik A. Jensen, George S. Worthen, Wei-Ming Yuan, Michela Perego, Wangkai Liu, Qiang Xiao, Fan Wu, Wei Zhou, Qiliang Cui, Shuyu Fu, Jie Zhou, Chunhong Jia, Dmitry I. Gabrilovich, Xing Li, Xiaoyu Li, Yanlai Tang, Yumei He, Yu-Feng Liu

Publikováno v: J Clin Invest

Inflammation plays a critical role in the development of severe neonatal morbidities. Myeloid-derived suppressor cells (MDSCs) were recently implicated in the regulation of immune responses in newborns. Here, we report that the presence of MDSCs and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67208bf1382497375e409ac22ea4b5ad
https://doi.org/10.1172/jci128164

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Type II alveolar cells with constitutive expression of MHCII and limited antigen presentation capacity contribute to improved respiratory viral disease outcomes

Autor: Edward E. Morrisey, Sushila A. Toulmin, Laurence C. Eisenlohr, Jeremy Katzen, George S Worthen, Maria C. Basil, Bhadiadra C, Jerome Lin, Andrew J. Paris

Type II alveolar cells (AT2s) are critical for basic respiratory homeostasis and tissue repair after lung injury. Prior studies indicate that AT2s also express major histocompatibility complex II (MHCII) molecules, but how MHCII expression by AT2s is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d54b5c8bd6701545036652724e5d2b2
https://doi.org/10.1101/2021.03.18.435984

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Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates

Autor: Katherine N. Theken, Amruta Naik, Shaon Sengupta, Mara Mermigos, Thomas G Brooks, Kaitlyn Forrest, Soon Yew Tang, Amita Sehgal, Nicholas F. Lahens, Garret A. FitzGerald, George S Worthen, Yasmine Issah

Publikováno v: eLife, Vol 10 (2021)
eLife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5632024507f03dcc5ff75cb1c808dace
https://doi.org/10.7554/elife.61241

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Loss of Circadian Protection in Adults Exposed to Neonatal Hyperoxia

Autor: Nicholas F. Lahens, Yasmine Issah, Katherine N. Theken, Garret A. FitzGerald, Amita Sehgal, George S Worthen, Kaitlyn Forrest, Thomas G Brooke, Shaon Sengupta, Amruta Naik, Soon Yew Tang

Adverse early life exposures having a lasting negative impact on health. For examples, neonatal hyperoxia which is a risk factor for chronic lung disease of prematurity or bronchopulmonary dysplasia (BPD) confers susceptibility to respiratory infecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eff9fb79044da921bb402721f852551f
https://doi.org/10.1101/2020.07.10.197277

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