Zobrazeno 1 - 10
of 52
pro vyhledávání: '"George S. Laszlo"'
Autor:
Salvatore Fiorenza, Sheryl Y.T. Lim, George S. Laszlo, Erik L. Kimble, Tinh-Doan Phi, Margaret C. Lunn-Halbert, Delaney R. Kirchmeier, Jenny Huo, Hans-Peter Kiem, Cameron J. Turtle, Roland B. Walter
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200854- (2024)
Current CD33-targeted immunotherapies typically recognize the membrane-distal V-set domain of CD33. Here, we show that decreasing the distance between T cell and leukemia cell membrane increases the efficacy of CD33 chimeric antigen receptor (CAR) T
Externí odkaz:
https://doaj.org/article/baa603e202b243ff9dc78a34c841b8f3
Autor:
Nicholas E. Petty, Stefan Radtke, Emily Fields, Olivier Humbert, Mallory J. Llewellyn, George S. Laszlo, Haiying Zhu, Keith R. Jerome, Roland B. Walter, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101121- (2023)
Current immunotherapeutic targets are often shared between neoplastic and normal hematopoietic stem and progenitor cells (HSPCs), leading to unwanted on-target, off-tumor toxicities. Deletion or modification of such targets to protect normal HSPCs is
Externí odkaz:
https://doaj.org/article/bbf076d5311d4ffc9cd892e144be7ab2
Autor:
George S. Laszlo, Mary E. Beddoe, Colin D. Godwin, Olivia M. Bates, Chelsea J. Gudgeon, Kimberly H. Harrington, Roland B. Walter
Publikováno v:
Haematologica, Vol 104, Iss 2 (2019)
Externí odkaz:
https://doaj.org/article/576b77cf1e4c464f85cfc2b2de7cd1a7
Autor:
George S. Laszlo, Todd A. Alonzo, Chelsea J. Gudgeon, Kimberly H. Harrington, Alex Kentsis, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Susana C. Raimondi, Betsy A. Hirsch, Alan S. Gamis, Soheil Meshinchi, Roland B. Walter
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-1 (2016)
Externí odkaz:
https://doaj.org/article/c828f6641677447fbb89446fcb0c0f60
Autor:
George S. Laszlo, Brenda M. Sandmaier, Allie R. Kehret, Johnnie J. Orozco, Donald K. Hamlin, Shannon L. Dexter, Sheryl Y. T. Lim, Frances M. Cole, Jenny Huo, D. Scott Wilbur, Roland B. Walter
Publikováno v:
Leukemia & Lymphoma. :1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e7d307c8d8291ef893ee00904ee0eb0
https://doi.org/10.1080/10428194.2023.2210710
https://doi.org/10.1080/10428194.2023.2210710
Autor:
George S. Laszlo, Johnnie J. Orozco, Allie R. Kehret, Margaret C. Lunn, Jenny Huo, Donald K. Hamlin, D. Scott Wilbur, Shannon L. Dexter, Melissa L. Comstock, Shyril O’Steen, Brenda M. Sandmaier, Damian J. Green, Roland B. Walter
Publikováno v:
Leukemia. 36:1485-1491
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca98e249d4e618e00b0d577cbc83be3f
https://doi.org/10.1038/s41375-022-01580-7
https://doi.org/10.1038/s41375-022-01580-7
Autor:
Roland B. Walter, Soheil Meshinchi, Alan S. Gamis, Betsy A. Hirsch, Susana C. Raimondi, Rhonda E. Ries, Yi-Cheng Wang, Robert B. Gerbing, Kimberly H. Harrington, Chelsea J. Gudgeon, Todd A. Alonzo, George S. Laszlo
Supplemental Figures 1-3, Tables 1-3. Supplemental Figure 1. Highly variable expression of MMRN1 in pediatric AML patient specimens. Supplemental Figure 2. Clinical outcome in patients with high and low MMRN1 expression. Supplemental Figure 3. Relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be789ce36ac6a1f3076057924909f514
https://doi.org/10.1158/1078-0432.22458807.v1
https://doi.org/10.1158/1078-0432.22458807.v1
Autor:
Roland B. Walter, Soheil Meshinchi, Alan S. Gamis, Betsy A. Hirsch, Susana C. Raimondi, Rhonda E. Ries, Yi-Cheng Wang, Robert B. Gerbing, Kimberly H. Harrington, Chelsea J. Gudgeon, Todd A. Alonzo, George S. Laszlo
Purpose: Exploratory gene expression array analyses suggested multimerin-1 (MMRN1) to be a predictive biomarker in acute myelogenous leukemia (AML). Following up on these studies, we evaluated the role of MMRN1 expression as outcome predictor in two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c84cf99806401e9949b2ebaa01c6661
https://doi.org/10.1158/1078-0432.c.6524046.v1
https://doi.org/10.1158/1078-0432.c.6524046.v1
Autor:
Florence Borot, Olivier Humbert, Gregory A Newby, Emily Fields, Sajeev Kohli, Stefan Radtke, George S. Laszlo, Thiyagaraj Mayuranathan, Abdullah Mahmood Ali, Mitchell J. Weiss, Jonathan S. Yen, Roland B. Walter, David R. Liu, Siddhartha Mukherjee, Hans-Peter Kiem
Publikováno v:
bioRxiv
On-target toxicity to normal cells is a major safety concern with targeted immune and gene therapies. Here, we developed a base editing (BE) approach exploiting a naturally occurring CD33 single nucleotide polymorphism leading to removal of full-leng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efe9077b262227a9035dab3e8b8664f
https://europepmc.org/articles/PMC9980058/
https://europepmc.org/articles/PMC9980058/
Autor:
Salvatore Fiorenza, Olivier Humbert, Hans-Peter Kiem, Colin D. Godwin, Benjamin G. Hoffstrom, Roland B. Walter, Eliotte E. Garling, Tinh-Doan Phi, George S. Laszlo, Olivia M. Bates, Margaret C. Lunn, Cameron J. Turtle, Colin Correnti
Publikováno v:
Leukemia
There is increasing interest in targeting CD33 in malignant and non-malignant disorders. In acute myeloid leukemia, longer survival with the CD33 antibody-drug conjugate gemtuzumab ozogamicin (GO) validates this strategy. Still, GO benefits only some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98a9e22852fbcca0f249cbcfb813884
https://doi.org/10.1038/s41375-021-01160-1
https://doi.org/10.1038/s41375-021-01160-1