Zobrazeno 1 - 10
of 263
pro vyhledávání: '"George S Baillie"'
Publikováno v:
Future Science OA, Vol 9, Iss 9 (2023)
Aim: PDE4D7 expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the PDE4D coding region were associated. Patients & methods: RNA
Externí odkaz:
https://doaj.org/article/54a2186f034a4b5fbe5ce12cc796c057
Publikováno v:
Future Science OA, Vol 7, Iss 2 (2021)
Much interest has been expended lately in characterizing the association between DExH-Box helicase 9 (DHX9) dysregulation and malignant development, however, the enigmatic nature of DHX9 has caused conflict as to whether it regularly functions as an
Externí odkaz:
https://doaj.org/article/cba462c2111b4ed29c4b84d0ff594825
Autor:
Amit Mahindra, Gonzalo Tejeda, Mario Rossi, Omar Janha, Imogen Herbert, Caroline Morris, Danielle C Morgan, Wendy Beattie, Augusto C Montezano, Brian Hudson, Andrew B Tobin, David Bhella, Rhian M Touyz, Andrew G Jamieson, George S Baillie, Connor M Blair
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260283 (2021)
SARS-CoV-2 viral attachment and entry into host cells is mediated by a direct interaction between viral spike glycoproteins and membrane bound angiotensin-converting enzyme 2 (ACE2). The receptor binding motif (RBM), located within the S1 subunit of
Externí odkaz:
https://doaj.org/article/bd3f0fee6eca437982991ad72b197890
Autor:
Arman Javadi, Ravi K Deevi, Emma Evergren, Elodie Blondel-Tepaz, George S Baillie, Mark GH Scott, Frederick C Campbell
Publikováno v:
eLife, Vol 6 (2017)
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signaling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein
Externí odkaz:
https://doaj.org/article/86bf581531044d0085ae49e06cb62ac6
Autor:
Christina Schoenherr, Adam Byron, Emma Sandilands, Ketevan Paliashvili, George S Baillie, Amaya Garcia-Munoz, Cristina Valacca, Francesco Cecconi, Bryan Serrels, Margaret C Frame
Publikováno v:
eLife, Vol 6 (2017)
Here, using mouse squamous cell carcinoma cells, we report a completely new function for the autophagy protein Ambra1 as the first described ‘spatial rheostat’ controlling the Src/FAK pathway. Ambra1 regulates the targeting of active phospho-Src
Externí odkaz:
https://doaj.org/article/7aa48c44f5304c8d82115c88d5b94df4
Autor:
Robbert Havekes, Alan J Park, Jennifer C Tudor, Vincent G Luczak, Rolf T Hansen, Sarah L Ferri, Vibeke M Bruinenberg, Shane G Poplawski, Jonathan P Day, Sara J Aton, Kasia Radwańska, Peter Meerlo, Miles D Houslay, George S Baillie, Ted Abel
Publikováno v:
eLife, Vol 5 (2016)
Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage. Here, we examine the impact of brief periods of sleep d
Externí odkaz:
https://doaj.org/article/32f1bf3a9ee043e8a3a8e3f02ed72e8f
Autor:
Jawad S Khalil, Paulo A. Saldanha, Connor M Blair, Jiayue Ling, Wei Ji, George S. Baillie, Khalid M Naseem, Leonid L Nikitenko, Francisco Rivero
The activity of myosin light chain phosphatase (MLCP) is fine-tuned by the phosphorylation status of the MLCP target subunit 1 (MYPT1), which is determined by the antagonistic effects of Rho kinase (ROCK) and cAMP/cGMP-dependent protein kinases (PKA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee74fe964fef6185883f51ab0f1c3e8a
https://doi.org/10.1101/2023.04.27.538407
https://doi.org/10.1101/2023.04.27.538407
Publikováno v:
Cancers; Volume 15; Issue 1; Pages: 262
Objectives: To investigate the association of the prognostic risk score CAPRA&PDE4D5/7/9 as measured on pre-surgical diagnostic needle biopsy tissue with pathological outcomes after radical prostatectomies in a clinically low–intermediate-risk pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dab381cd20882cf4f4e41fb7bc502b
Autor:
Alexandra D. Brown, Kathleen L. Vergunst, Makenzie Branch, Connor M. Blair, Denis J. Dupré, George S. Baillie, David N. Langelaan
The microphthalmia-associated transcription factor (MITF) is a master regulator of the melanocyte cell lineage. Aberrant MITF activity can lead to multiple malignancies including skin cancer, where it modulates the proliferation and invasiveness of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d8876f2e151cbef396eab8cb3107b34
https://doi.org/10.1101/2022.08.28.505448
https://doi.org/10.1101/2022.08.28.505448
Autor:
Alice Main, Andri Bogusalvskyii, Jacqueline Howie, Chien-wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date. In the heart, S-palmitoylation reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70822cf6eb2faffd02fabc5cc956e698
https://doi.org/10.1101/2022.08.19.504400
https://doi.org/10.1101/2022.08.19.504400