Cannabinoid-Inspired Inhibitors of the SARS-CoV-2 Coronavirus 2′-O-Methyltransferase (2′-O-MTase) Non-Structural Protein (Nsp10–16)

Autor: Menny M. Benjamin, George S. Hanna, Cody F. Dickinson, Yeun-Mun Choo, Xiaojuan Wang, Jessica A. Downs-Bowen, Ramyani De, Tamara R. McBrayer, Raymond F. Schinazi, Sarah E. Nielson, Joan M. Hevel, Pankaj Pandey, Robert J. Doerksen, Danyelle M. Townsend, Jie Zhang, Zhiwei Ye, Scott Wyer, Lucas Bialousow, Mark T. Hamann

Publikováno v: Molecules, Vol 29, Iss 21, p 5081 (2024)

The design and synthesis of antiviral compounds were guided by computationally predicted data against highly conserved non-structural proteins (Nsps) of the SARS-CoV-2 coronavirus. Chromenephenylmethanone-1 (CPM-1), a novel biphenylpyran (BPP), was s

Externí odkaz: https://doaj.org/article/9f48bea30a7a4d548c45cff1360d4a7f

Cannabinoid-Inspired Inhibitors of the SARS-CoV-2 Coronavirus 2′- O -Methyltransferase (2′- O -MTase) Non-Structural Protein (Nsp10–16).

Autor: Benjamin, Menny M.¹ (AUTHOR) benjamim@musc.edu, Hanna, George S.¹ (AUTHOR), Dickinson, Cody F.¹ (AUTHOR), Choo, Yeun-Mun² (AUTHOR), Wang, Xiaojuan³ (AUTHOR), Downs-Bowen, Jessica A.⁴ (AUTHOR), De, Ramyani⁴ (AUTHOR), McBrayer, Tamara R.⁴ (AUTHOR), Schinazi, Raymond F.⁴ (AUTHOR), Nielson, Sarah E.⁵ (AUTHOR), Hevel, Joan M.⁵ (AUTHOR), Pandey, Pankaj⁶ (AUTHOR), Doerksen, Robert J.⁷ (AUTHOR), Townsend, Danyelle M.⁸ (AUTHOR), Zhang, Jie⁸ (AUTHOR), Ye, Zhiwei⁸ (AUTHOR), Wyer, Scott¹ (AUTHOR), Bialousow, Lucas¹ (AUTHOR), Hamann, Mark T.^1,9 (AUTHOR) hamannm@musc.edu

Publikováno v: Molecules. Nov2024, Vol. 29 Issue 21, p5081. 17p.

The St. Louis Commune of 1877 : Communism in the Heartland

Autor: Mark Kruger

Following the Civil War, large corporations emerged in the United States and became intent on maximizing their power and profits at all costs. Political corruption permeated American society as those corporate entities grew and spread across the coun