Zobrazeno 1 - 10
of 263
pro vyhledávání: '"George S, Baillie"'
Autor:
Saruda Thongyim, Thomas A. Wright, Pachara Sattayawat, Thida Kaewkod, George S. Baillie, Yingmanee Tragoolpua, Siriphorn Jangsutthivorawat, Aussara Panya
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Periodontal disease is more prevalent in patients with diabetes, and it has a negative impact on their quality of life. Inhibiting the infection and inflammation processes that cause periodontal disease can reduce the severity of the disease and chan
Externí odkaz:
https://doaj.org/article/be1c34abb12347e78b311ae2f757789f
Autor:
Sean F. Cooke, Thomas A. Wright, Yuan Yan Sin, Jiayue Ling, Elka Kyurkchieva, Nattaporn Phanthaphol, Thomas Mcskimming, Katharine Herbert, Selma Rebus, Andrew V. Biankin, David K. Chang, George S. Baillie, Connor M. Blair
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is considered the third leading cause of cancer mortality in the western world, offering advanced stage patients with few viable treatment options. Consequently, there remains an urgent unmet need to d
Externí odkaz:
https://doaj.org/article/16d4a69d0ef14307a98c84f3b800fbc9
Autor:
Chloe Gulliver, Tara Busiau, Ashleigh Byrne, Jane E. Findlay, Ralf Hoffmann, George S. Baillie
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 707-725 (2024)
A robust body of work has demonstrated that a reduction in cAMP‐specific 3′,5′‐cyclic phosphodiesterase 4D isoform 7 (PDE4D7) is linked with negative prostate cancer outcomes; however, the exact molecular mechanism that underpins this relatio
Externí odkaz:
https://doaj.org/article/40e3306a4c564677806f725011d25c00
Publikováno v:
Future Science OA, Vol 9, Iss 9 (2023)
Aim: PDE4D7 expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the PDE4D coding region were associated. Patients & methods: RNA
Externí odkaz:
https://doaj.org/article/54a2186f034a4b5fbe5ce12cc796c057
Autor:
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date. In the heart, S-palmitoylation reg
Externí odkaz:
https://doaj.org/article/7cbe5c5a5f744ee8954ab054d0919e50
Autor:
Elka Kyurkchieva, George S. Baillie
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 7, p 133 (2023)
The second messenger, cyclic adenosine monophosphate (cAMP), is a master regulator of signal transduction that maintains cell homeostasis. A fine balance between cAMP synthesis by adenylyl cyclase and degradation by phosphodiesterases (PDEs) underpin
Externí odkaz:
https://doaj.org/article/8d7ca209cf6940caa3f08b1381a5dadd
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Recent advances in the treatment of melanoma that involve immunotherapy and B-Raf inhibition have revolutionised cancer care for this disease. However, an un-met clinical need remains in B-Raf inhibitor resistant patients where fi
Externí odkaz:
https://doaj.org/article/595c5659b7134552a9c0581e9e360ed4
Publikováno v:
Future Science OA, Vol 7, Iss 2 (2021)
Much interest has been expended lately in characterizing the association between DExH-Box helicase 9 (DHX9) dysregulation and malignant development, however, the enigmatic nature of DHX9 has caused conflict as to whether it regularly functions as an
Externí odkaz:
https://doaj.org/article/cba462c2111b4ed29c4b84d0ff594825
Autor:
Amit Mahindra, Gonzalo Tejeda, Mario Rossi, Omar Janha, Imogen Herbert, Caroline Morris, Danielle C. Morgan, Wendy Beattie, Augusto C. Montezano, Brian Hudson, Andrew B. Tobin, David Bhella, Rhian M. Touyz, Andrew G. Jamieson, George S. Baillie, Connor M. Blair
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
SARS-CoV-2 viral attachment and entry into host cells is mediated by a direct interaction between viral spike glycoproteins and membrane bound angiotensin-converting enzyme 2 (ACE2). The receptor binding motif (RBM), located within the S1 subunit of
Externí odkaz:
https://doaj.org/article/f0f07f9a6ed44895934fa969a58c9b5e
Autor:
Jamie J. L. Williams, Nasser Alotaiq, William Mullen, Richard Burchmore, Libin Liu, George S. Baillie, Fred Schaper, Paul F. Pilch, Timothy M. Palmer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
SOCS3 is an important negative feedback inhibitor of JAK–STAT-mediated cytokine signalling. Here the authors implicate cavin-1 — an essential component of caveolae — in the recruitment of SOCS3 to the plasma membrane to prevent sustained cytoki
Externí odkaz:
https://doaj.org/article/150955b131d248018bd4158e8688ea0e