Zobrazeno 1 - 10
of 57
pro vyhledávání: '"George Rosenberger"'
Autor:
George Rosenberger, Wenxue Li, Mikko Turunen, Jing He, Prem S. Subramaniam, Sergey Pampou, Aaron T. Griffin, Charles Karan, Patrick Kerwin, Diana Murray, Barry Honig, Yansheng Liu, Andrea Califano
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid, context-specific signaling network rewir
Externí odkaz:
https://doaj.org/article/858e3837977347e38a966598bebfacfc
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102293- (2023)
Summary: The Size-Exclusion Chromatography Analysis Toolkit (SECAT) elucidates protein complex dynamics using co-fractionated bottom-up mass spectrometry (CF-MS) data. Here, we present a protocol for the network-centric analysis and interpretation of
Externí odkaz:
https://doaj.org/article/ea8f64263af94ef4aa8024ae0df404b0
Autor:
Vadim Demichev, Lukasz Szyrwiel, Fengchao Yu, Guo Ci Teo, George Rosenberger, Agathe Niewienda, Daniela Ludwig, Jens Decker, Stephanie Kaspar-Schoenefeld, Kathryn S. Lilley, Michael Mülleder, Alexey I. Nesvizhskii, Markus Ralser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
The dia-PASEF technology uses ion mobility separation to reduce signal interferences and increase sensitivity of mass spectrometry-based proteomics. The authors present algorithms and a software solution, which boost proteomic depth in dia-PASEF expe
Externí odkaz:
https://doaj.org/article/530223c882bd4d63b31f0e4036920910
Autor:
Barbora Salovska, Erli Gao, Sophia Müller‐Dott, Wenxue Li, Carlos Chacon Cordon, Shisheng Wang, Aurelien Dugourd, George Rosenberger, Julio Saez‐Rodriguez, Yansheng Liu
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 2, Pp n/a-n/a (2023)
Abstract Background The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role of metformin in the prevention and treatment of cancer
Externí odkaz:
https://doaj.org/article/7d1cadd1d0054306a8ad9fc8134f036d
Autor:
Qian Chen, Mairene Coto-Llerena, Aleksei Suslov, Raphael Dias Teixeira, Isabel Fofana, Sandro Nuciforo, Maike Hofmann, Robert Thimme, Nina Hensel, Volker Lohmann, Charlotte K. Y. Ng, George Rosenberger, Stefan Wieland, Markus H. Heim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
A genetic variant in the IFN-lambda 4 gene has been associated with poor hepatitis C virus prognosis but it is not clear how this functions. Here the authors show that IFN-lambda 4 promotes ER stress and inhibits presentation of HCV epitopes to CD8+
Externí odkaz:
https://doaj.org/article/490276d24a40458c86a47d3c716fb078
Autor:
Isabell Bludau, Max Frank, Christian Dörig, Yujia Cai, Moritz Heusel, George Rosenberger, Paola Picotti, Ben C. Collins, Hannes Röst, Ruedi Aebersold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Many proteins exist in various proteoforms but detecting these variants by bottom-up proteomics remains difficult. Here, the authors present a computational approach based on peptide correlation analysis to identify and characterize proteoforms from
Externí odkaz:
https://doaj.org/article/4bc622ef871944e7b4a94176e06f1144
Autor:
Barbora Salovska, Hongwen Zhu, Tejas Gandhi, Max Frank, Wenxue Li, George Rosenberger, Chongde Wu, Pierre‐Luc Germain, Hu Zhou, Zdenek Hodny, Lukas Reiter, Yansheng Liu
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 3, Pp 1-19 (2020)
Abstract Profiling of biological relationships between different molecular layers dissects regulatory mechanisms that ultimately determine cellular function. To thoroughly assess the role of protein post‐translational turnover, we devised a strateg
Externí odkaz:
https://doaj.org/article/7eb9b1cb88724f28b0e02d5b8de1d4d0
Autor:
Moritz Heusel, Isabell Bludau, George Rosenberger, Robin Hafen, Max Frank, Amir Banaei‐Esfahani, Audrey van Drogen, Ben C Collins, Matthias Gstaiger, Ruedi Aebersold
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 1, Pp 1-22 (2019)
Abstract Proteins are major effectors and regulators of biological processes that can elicit multiple functions depending on their interaction with other proteins. The organization of proteins into macromolecular complexes and their quantitative dist
Externí odkaz:
https://doaj.org/article/94f8741ead474fbc9b1bd932e6cc5d80
Autor:
Christina Ludwig, Ludovic Gillet, George Rosenberger, Sabine Amon, Ben C Collins, Ruedi Aebersold
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 8, Pp 1-23 (2018)
Abstract Many research questions in fields such as personalized medicine, drug screens or systems biology depend on obtaining consistent and quantitatively accurate proteomics data from many samples. SWATH‐MS is a specific variant of data‐indepen
Externí odkaz:
https://doaj.org/article/212c63d12c084d8d8234958f755d97d2
Autor:
Ben C. Collins, Christie L. Hunter, Yansheng Liu, Birgit Schilling, George Rosenberger, Samuel L. Bader, Daniel W. Chan, Bradford W. Gibson, Anne-Claude Gingras, Jason M. Held, Mio Hirayama-Kurogi, Guixue Hou, Christoph Krisp, Brett Larsen, Liang Lin, Siqi Liu, Mark P. Molloy, Robert L. Moritz, Sumio Ohtsuki, Ralph Schlapbach, Nathalie Selevsek, Stefani N. Thomas, Shin-Cheng Tzeng, Hui Zhang, Ruedi Aebersold
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
SWATH-mass spectrometry consists of a data-independent acquisition and a targeted data analysis strategy that aims to maintain the favorable quantitative characteristics on the scale of thousands of proteins. Here, using data generated by eleven grou
Externí odkaz:
https://doaj.org/article/44740b6f8c2d466ca5462d8455eae709