Application of Mendelian randomization to explore the causal role of the human gut microbiome in colorectal cancer

Autor: Charlie Hatcher, George Richenberg, Samuel Waterson, Long H. Nguyen, Amit D. Joshi, Robert Carreras-Torres, Victor Moreno, Andrew T. Chan, Marc Gunter, Yi Lin, Conghui Qu, Mingyang Song, Graham Casey, Jane C. Figueiredo, Stephen B. Gruber, Jochen Hampe, Heather Hampel, Mark A. Jenkins, Temitope O. Keku, Ulrike Peters, Catherine M. Tangen, Anna H. Wu, David A. Hughes, Malte C. Rühlemann, Jeroen Raes, Nicholas J. Timpson, Kaitlin H. Wade

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract The role of the human gut microbiome in colorectal cancer (CRC) is unclear as most studies on the topic are unable to discern correlation from causation. We apply two-sample Mendelian randomization (MR) to estimate the causal relationship be

Externí odkaz: https://doaj.org/article/3de8785a834d4867853ad4bb6d8b5078

Abstract 6504: Germline genetically predicted body mass index is associated with endometrial cancer somatic transcriptomic, immune, and mutational signatures in The Cancer Genome Atlas

Autor: George Richenberg, Victoria Gray, Carina Owen, Tom Gaunt, Caroline Relton, Emma Vincent, Siddhartha Kar

Publikováno v: Cancer Research. 83:6504-6504

High body mass index (BMI) is a causal risk factor for endometrial cancer but the molecular mechanisms underlying this association remain elusive. Here we sought to characterize the tumor genomic landscape of endometrial cancers that have developed o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a46c4e535302cd21e0ae797387ec5849
https://doi.org/10.1158/1538-7445.am2023-6504

Application of Mendelian randomization to explore the causal role of the human gut microbiome in colorectal cancer.

Autor: Hatcher, Charlie^1,2 (AUTHOR), Richenberg, George^1,2 (AUTHOR), Waterson, Samuel^2,3 (AUTHOR), Nguyen, Long H.⁴ (AUTHOR), Joshi, Amit D.⁴ (AUTHOR), Carreras-Torres, Robert^5,6 (AUTHOR), Moreno, Victor^5,7,8,9 (AUTHOR), Chan, Andrew T.⁴ (AUTHOR), Gunter, Marc¹⁰ (AUTHOR), Lin, Yi¹¹ (AUTHOR), Qu, Conghui¹² (AUTHOR), Song, Mingyang^13,14,15 (AUTHOR), Casey, Graham¹⁶ (AUTHOR), Figueiredo, Jane C.¹⁷ (AUTHOR), Gruber, Stephen B.¹⁸ (AUTHOR), Hampe, Jochen¹⁹ (AUTHOR), Hampel, Heather²⁰ (AUTHOR), Jenkins, Mark A.²¹ (AUTHOR), Keku, Temitope O.²² (AUTHOR), Peters, Ulrike¹² (AUTHOR)

Publikováno v: Scientific Reports. 7/26/2023, Vol. 13 Issue 1, p1-14. 14p.

Trade and Traders in Mid-Victorian Liverpool : Mercantile Business and the Making of a World Port

Autor: Graeme Milne

This book charts the development of Liverpool's trade, shipping and business culture in the third quarter of the nineteenth century. Using previously neglected evidence, it assesses the causes and consequences of major changes in the port's economy,