Zobrazeno 1 - 5
of 5
pro vyhledávání: '"George R. Wilmot"'
The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications
Autor:
Louisa P. Selvadurai, Susan L. Perlman, George R. Wilmot, Sub H. Subramony, Christopher M. Gomez, Tetsuo Ashizawa, Henry L. Paulson, Chiadi U. Onyike, Liana S. Rosenthal, Haris I. Sair, Sheng-Han Kuo, Eva-Maria Ratai, Theresa A. Zesiewicz, Khalaf O. Bushara, Gülin Öz, Cameron Dietiker, Michael D. Geschwind, Alexandra B. Nelson, Puneet Opal, Talene A. Yacoubian, Peggy C. Nopoulos, Vikram G. Shakkottai, Karla P. Figueroa, Stefan M. Pulst, Peter E. Morrison, Jeremy D. Schmahmann
Spinocerebellar ataxias (SCAs) are progressive neurodegenerative disorders, but there is no metric that predicts disease severity over time. We hypothesized that by developing a new metric, the Severity Factor (S-Factor) using immutable disease param
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9f84d79ecb1e743ffa267784f9f2c4
https://escholarship.org/uc/item/798300bm
https://escholarship.org/uc/item/798300bm
Autor:
George R. Wilmot, Bernard W. Agranoff, Rafael P. Ballestero, Michael L. Leski, Michael D. Uhler
Publikováno v:
Proceedings of the National Academy of Sciences. 92:8621-8625
Using data derived from peptide sequencing of p68/70, a protein doublet induced during optic nerve regeneration in goldfish, we have isolated cDNAs that encode RICH (regeneration-induced CNPase homolog) from a goldfish regenerating retina cDNA librar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fba59d36ebdd470827860329eebb798
https://doi.org/10.1073/pnas.92.19.8621
https://doi.org/10.1073/pnas.92.19.8621
Publikováno v:
The Journal of Neuroscience. 13:387-401
Previous attempts to characterize the molecular events that support successful regeneration of axotomized goldfish retinal ganglion cells (RGCs) have led to the discovery of an acidic protein doublet in retina that displays an increased incorporation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994d3387241830c25ba4e63b231ed7b3
https://doi.org/10.1523/jneurosci.13-01-00387.1993
https://doi.org/10.1523/jneurosci.13-01-00387.1993
Publikováno v:
The Journal of biological chemistry. 272(17)
Biochemical characterization of changes in gene expression that accompany optic nerve regeneration has led to the identification of proteins that may play key roles in the regeneration process. In this report, a cDNA encoding gRICH70, a novel isoform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ad1a7d0ccc67139edbbb5b1824f951
https://pubmed.ncbi.nlm.nih.gov/9111061
https://pubmed.ncbi.nlm.nih.gov/9111061
Publikováno v:
Brain research. 571(1)
Kainic acid is supposed to be a specific agonist for a subclass of excitatory glutamate receptors in the vertebrate CNS. An investigation of (2 nM) [3H]kainic acid binding sites in goldfish brain, using quantitative autoradiography, has revealed evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7435a8ceeaac86ce1649f9e77cd02a
https://pubmed.ncbi.nlm.nih.gov/1377085
https://pubmed.ncbi.nlm.nih.gov/1377085