Zobrazeno 1 - 10
of 507
pro vyhledávání: '"George R. Uhl"'
Autor:
Yuki Moriya, Yoshiyuki Kasahara, Masafumi Shimada, Yasufumi Sakakibara, Hideaki Fujii, Hiroshi Nagase, Soichiro Ide, Kazutaka Ikeda, F. Scott Hall, George R. Uhl, Ichiro Sora
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 3, Pp 135-141 (2023)
Previous pharmacological data have shown the possible existence of functional interactions between μ- (MOP), κ- (KOP), and δ-opioid receptors (DOP) in pain and mood disorders. We previously reported that MOP knockout (KO) mice exhibit a lower stre
Externí odkaz:
https://doaj.org/article/09bb7dc779c5447daf3862372f76af88
Autor:
George R. Uhl
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
Substance use disorders provide challenges for development of effective medications. Use of abused substances is likely initiated, sustained and “quit” by complex brain and pharmacological mechanisms that have both genetic and environmental deter
Externí odkaz:
https://doaj.org/article/66345e6601c14147a229bea2534a352f
Publikováno v:
Neuropsychopharmacology Reports, Vol 41, Iss 1, Pp 91-101 (2021)
Abstract Aims 5‐Methoxy‐N,N‐diisopropyltryptamine (5‐MeO‐DIPT) is a synthetic orally active hallucinogenic tryptamine analogue. The present study examined whether the effects of 5‐MeO‐DIPT involve the serotonin transporter (SERT) and se
Externí odkaz:
https://doaj.org/article/9ec6adf1b7d34777af4a64be00906261
Autor:
Yoshiyuki Kasahara, Yasufumi Sakakibara, Takashi Hiratsuka, Yuki Moriya, Klaus‐Peter Lesch, F. Scott Hall, George R. Uhl, Ichiro Sora
Publikováno v:
Neuropsychopharmacology Reports, Vol 39, Iss 2, Pp 130-133 (2019)
Abstract Aim Repeated psychostimulant drug treatment, including methamphetamine, in rodents readily produces behavioral sensitization, which reflects altered brain function caused by repeated drug exposure. Dendritic remodeling of medium spiny neuron
Externí odkaz:
https://doaj.org/article/b28b36dddd2b4b0e85c5cfd36a3d1adc
Autor:
Miho Tanaka, Atsushi Sato, Shinya Kasai, Yoko Hagino, Hiroko Kotajima-Murakami, Hirofumi Kashii, Yukio Takamatsu, Yasumasa Nishito, Masumi Inagaki, Masashi Mizuguchi, F. Scott Hall, George R. Uhl, Dennis Murphy, Ichiro Sora, Kazutaka Ikeda
Publikováno v:
Molecular Autism, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract Background Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms. Methods We
Externí odkaz:
https://doaj.org/article/25c07c7ab67344558030fde5cba9da02
Autor:
Soichiro Ide, Yuiko Ikekubo, Jennifer Hua, Yukio Takamatsu, George R. Uhl, Ichiro Sora, Kazutaka Ikeda
Publikováno v:
Neuropsychopharmacology Reports, Vol 38, Iss 3, Pp 149-153 (2018)
Abstract Aim Attention‐deficit/hyperactivity disorder is a heterogeneous neurobiological disorder that is characterized by inattention, impulsivity, and an increase in motor activity. Although methylphenidate has been used as a medication for decad
Externí odkaz:
https://doaj.org/article/549a64fffcf04384a637ec1ef3bb5358
Autor:
Jana Drgonova, Donna Walther, G. Luke Hartstein, Mohammad O. Bukhari, Michael H. Baumann, Jonathan Katz, F. Scott Hall, Elizabeth R. Arnold, Shaun Flax, Anthony Riley, Olga Rivero, Klaus-Peter Lesch, Juan Troncoso, Barbara Ranscht, George R. Uhl
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 537-547 (2016)
Abstract The Cadherin 13 (CDH13) gene encodes a cell adhesion molecule likely to influence development and connections of brain circuits that modulate addiction, locomotion and cognition, including those that involve midbrain dopamine neurons. Human
Externí odkaz:
https://doaj.org/article/f5a73434f62e4c7da5554e4adfb91325
Publikováno v:
Drug Target Insights, Vol 2016, Iss 10, Pp 1-7 (2016)
Externí odkaz:
https://doaj.org/article/feb99750492a4677888e9b5f32b00d29
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2018)
Background: μ-opioid receptor knockout (MOP-KO) mice display baseline hyperalgesia. We have recently identified changes in tissue volume in the periaqueductal gray matter (PAG) using magnetic resonance imaging voxel-based morphometry. Changes in the
Externí odkaz:
https://doaj.org/article/6b3ed971faf249dd84f98a69f1801cea
Publikováno v:
Neural Plasticity, Vol 2018 (2018)
A variety of genetic approaches, including twin studies, linkage studies, and candidate gene studies, has established a firm genetic basis for addiction. However, there has been difficulty identifying the precise genes that underlie addiction liabili
Externí odkaz:
https://doaj.org/article/3656551342f9426395c4f92e3b70b960