Zobrazeno 1 - 10
of 29
pro vyhledávání: '"George R. Molloy"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1728:18-33
Our previous studies established in U87-MG glioblastoma cells that elevated cAMP increased transcription of the endogenous as well as a transiently-transfected brain creatine kinase (CKB) gene, despite the absence of a cAMP response element (CRE) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccc1f31d0153af58cffb7c88d088857
https://doi.org/10.1016/j.bbaexp.2005.01.007
https://doi.org/10.1016/j.bbaexp.2005.01.007
Publikováno v:
Developmental Neuroscience. 25:421-435
Brain creatine kinase (CKB) has a central role in the regeneration of ATP in the brain. During postnatal development of rat brain cerebrum, the CKB protein level was very low at postnatal day 1 and week 1 but by week 4 had increased 6- to 7-fold and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96373370ef7497748149cb42cda4a03
https://doi.org/10.1159/000075668
https://doi.org/10.1159/000075668
Publikováno v:
Journal of Neuroscience Research. 56:371-385
Our previous studies have shown that transcription of brain creatine kinase (CKB) mRNA in U87-MG glioblastoma cells is stimulated by a forskolin-mediated increase in cyclic AMP (cAMP) via a pathway involving protein kinase A (PKA) and the activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c930cc6f329f21732137e26ccd2c82
https://doi.org/10.1002/(sici)1097-4547(19990515)56:4<371::aid-jnr5>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19990515)56:4<371::aid-jnr5>3.0.co
Publikováno v:
Developmental Neuroscience. 19:384-394
Creatine kinases (CK) catalyze the reversible transfer of a high energy phosphate group between creatine phosphate and ADP to regenerate ATP in cell types where the requirements for ATP are extensive and/or sudden. Previously, we have shown in primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4c4e3f6191d294806ec3fca3754dcc
https://doi.org/10.1159/000111236
https://doi.org/10.1159/000111236
Publikováno v:
Developmental Neuroscience. 19:375-383
The cytoplasmic creatine kinase (CKB) enzyme has a central role in the regeneration of ATP in the brain. We have shown previously that CKB mRNA levels in cultured primary rat brain astrocytes and oligodendrocytes are much higher than in primary neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0089096c26bd8915b2465a9b198c9459
https://doi.org/10.1159/000111235
https://doi.org/10.1159/000111235
Publikováno v:
Molecular Brain Research. 41:50-56
The creatine kinase-B (CKB) enzyme is proposed to have a pivotal role in the regeneration of ATP in the nervous system. In the present study, the steady-state levels of CKB mRNA were determined by RNase protection assay in seventeen separate brain re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4645124c000fd6d1d3b975a03ec7ca4
https://doi.org/10.1016/0169-328x(96)00065-4
https://doi.org/10.1016/0169-328x(96)00065-4
Publikováno v:
Molecular and Cellular Biology. 14:8483-8492
The creatine kinases (CK) regenerate ATP for cellular reactions with a high energy expenditure. While muscle CK (CKM) is expressed almost exclusively in adult skeletal and cardiac muscle, brain CK (CKB) expression is more widespread and is highest in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c58c0f0a86caee926a8680255a478af
https://doi.org/10.1128/mcb.14.12.8483-8492.1994
https://doi.org/10.1128/mcb.14.12.8483-8492.1994
Publikováno v:
Journal of Neuroscience Research. 39:70-82
The brain creatine kinase (CKB) gene is expressed in a variety of tissues with highest expression seen in the brain. We have previously shown in primary rat brain cell cultures that CKB mRNA levels are high in oligodendrocytes and astrocytes and low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659965b0efa021455b6ad571767c1b03
https://doi.org/10.1002/jnr.490390110
https://doi.org/10.1002/jnr.490390110
Publikováno v:
Journal of Neuroscience Research. 35:92-102
We have recently shown that while brain creatine kinase (CKB) mRNA was detectable in RNA from cultured primary rat brain neurons, CKB mRNA was about 15-fold higher in primary astrocytes and 17-fold higher in oligodendrocytes (Molloy et al., J Neuroch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967e01ebcebf7096dbf2a391370bf0a1
https://doi.org/10.1002/jnr.490350111
https://doi.org/10.1002/jnr.490350111
Publikováno v:
Biochemical Journal
Biochemical Journal, Portland Press, 2002, 367 (2), pp.369-380
Biochemical Journal, Portland Press, 2002, 367 (Pt 2), pp.369-80. ⟨10.1042/BJ20020709⟩
Biochemical Journal, Portland Press, 2002, 367 (2), pp.369-380
Biochemical Journal, Portland Press, 2002, 367 (Pt 2), pp.369-80. ⟨10.1042/BJ20020709⟩
International audience; Transcription and accumulation of brain-type creatine kinase (CKB) mRNA and its protein was examined during postnatal development of rat brain cerebellum, the brain region containing highest CKB mRNA in the adult. CKB protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4505ebad7c1106903fe51206ba15f1c
https://hal.univ-grenoble-alpes.fr/hal-01990762
https://hal.univ-grenoble-alpes.fr/hal-01990762
