Zobrazeno 1 - 10
of 16
pro vyhledávání: '"George R. Lankas"'
Autor:
Hyun O. Ok, Tesfaye Biftu, Ann E. Weber, Scott D. Edmondson, William P. Feeney, Joseph K. Wu, Kelly Ann Pryor, George R. Lankas, Reshma A. Patel, Aleksandr Petrov, Xiaoping Zhang, Xiaoxia Qian, Nancy A. Thornberry, Dooseop Kim, Andrea Woods, Ranabir Sinha Roy, George J. Eiermann, Chi-Chung Chan, Dawn E. Ippolito, Maria G. Beconi, Lan Zhu, Leah Bitalac Reigle, Huaibing He, Dennis M. Zaller, Barbara Leiting, Kathryn A. Lyons
Publikováno v:
Diabetes. 54:2988-2994
Dipeptidyl peptidase (DPP)-IV inhibitors are a new approach to the treatment of type 2 diabetes. DPP-IV is a member of a family of serine peptidases that includes quiescent cell proline dipeptidase (QPP), DPP8, and DPP9; DPP-IV is a key regulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d32fb4e0599d1cdc316ba006f027e4
https://doi.org/10.2337/diabetes.54.10.2988
https://doi.org/10.2337/diabetes.54.10.2988
Autor:
Jeffery W Lawrence, Clay B. Frederick, William H. Schaefer, Dana A. Stoffregen, Amy F Loughlin, Dennis C. Dean, George R. Lankas, Nathan X. Yu, Lori Mixson, Conrad E. Raab
Publikováno v:
Toxicology and Applied Pharmacology. 194:10-23
As a class, hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors can potentially cause skeletal myopathy. One statin, cerivastatin, has recently been withdrawn from the market due to an unacceptably high incidence of rhabdomyolysis. The me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad9b70146d06ef54ddd496575cdb829
https://doi.org/10.1016/j.taap.2003.08.013
https://doi.org/10.1016/j.taap.2003.08.013
Publikováno v:
Food and Chemical Toxicology. 39:367-374
Thiabendazole (TBZ) is a potent anthelmintic and fungicide used in the treatment of parasitic infections in humans and domestic animals and post-harvest protection of agricultural commodities. TBZ is not teratogenic or selectively foetotoxic in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78afa5e3fcb07bdfe120a1c4e1c2ba83
https://doi.org/10.1016/s0278-6915(00)00148-4
https://doi.org/10.1016/s0278-6915(00)00148-4
Publikováno v:
Toxicology and Applied Pharmacology. 143:357-365
A subpopulation of CF-1 mice is unusual in its sensitivity to the avermectins, abamectin and ivermectin, with neurotoxicity occurring at 100-fold lower doses than in other species and mouse strains. We have shown that the sensitive CF-1 mice are defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957dc291c2992488096fa873f52571db
https://doi.org/10.1006/taap.1996.8086
https://doi.org/10.1006/taap.1996.8086
Publikováno v:
Toxicology. 108:207-215
L-695,256 is a novel 2-fluorenonyl carbapenem antibiotic with significant antimicrobial activity against strains of methicillin-resistant Staphylococci. This prototype compound was administered intravenously to rhesus monkeys (Macaca mulatta) at does
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d61089fbdef46fe479af4adc770e289
https://doi.org/10.1016/0300-483x(96)03305-7
https://doi.org/10.1016/0300-483x(96)03305-7
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology.
BACKGROUND: Lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reduces de novo cholesterol biosynthesis primarily in the liver. Since cholesterol is a major component of brain myelin and peak periods of brain myelination occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0743aa133ea9b17c3ba0200557c76f72
https://doi.org/10.1002/bdrb.20296
https://doi.org/10.1002/bdrb.20296
Autor:
George R, Lankas, Barbara, Leiting, Ranabir Sinha, Roy, George J, Eiermann, Maria G, Beconi, Tesfaye, Biftu, Chi-Chung, Chan, Scott, Edmondson, William P, Feeney, Huaibing, He, Dawn E, Ippolito, Dooseop, Kim, Kathryn A, Lyons, Hyun O, Ok, Reshma A, Patel, Aleksandr N, Petrov, Kelly Ann, Pryor, Xiaoxia, Qian, Leah, Reigle, Andrea, Woods, Joseph K, Wu, Dennis, Zaller, Xiaoping, Zhang, Lan, Zhu, Ann E, Weber, Nancy A, Thornberry
Publikováno v:
Diabetes. 54(10)
Dipeptidyl peptidase (DPP)-IV inhibitors are a new approach to the treatment of type 2 diabetes. DPP-IV is a member of a family of serine peptidases that includes quiescent cell proline dipeptidase (QPP), DPP8, and DPP9; DPP-IV is a key regulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0bc87f350446e11e798e5fcfe533a679
https://pubmed.ncbi.nlm.nih.gov/16186403
https://pubmed.ncbi.nlm.nih.gov/16186403
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 12(4)
A subpopulation of the CF-1 mouse strain contains a spontaneous mutation in the P-glycoprotein (Pgp) mdr1a gene, which leads to a lack of mdr1a expression in the placenta as well as brain and intestine. Individual CF-1 mice can be identified accordin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3514f34b0f15f305c9832c92bb0d73fb
https://pubmed.ncbi.nlm.nih.gov/9717696
https://pubmed.ncbi.nlm.nih.gov/9717696
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 32(3)
The potential reproductive toxicity of the fungicide and anthelmintic thiabendazole (TBZ) was assessed in Sprague-Dawley rats for two generations. Doses of 10, 30 or 90 mg/kg/day were administered by way of the diet beginning at 8 wk of age for the F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be2920f0bc280effd4ba572c8d59c9b
https://pubmed.ncbi.nlm.nih.gov/8157218
https://pubmed.ncbi.nlm.nih.gov/8157218
Publikováno v:
Toxicologic pathology. 22(2)
When chemicals that are nongenotoxic in conventional assays produce increases in tumor incidence in rodents in chronic bioassays, the determination of the significance of these data for human safety is a challenging task. An important first step in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccc889a6175cbce4872e4713a3ea5fe
https://pubmed.ncbi.nlm.nih.gov/7973360
https://pubmed.ncbi.nlm.nih.gov/7973360