Zobrazeno 1 - 10
of 42
pro vyhledávání: '"George R R, Bell"'
Autor:
Kacey VanderVorst, Courtney A. Dreyer, Jason Hatakeyama, George R. R. Bell, Julie A. Learn, Anastasia L. Berg, Maria Hernandez, Hyun Lee, Sean R. Collins, Kermit L. Carraway
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-19 (2023)
Abstract Background In light of the growing appreciation for the role of collective cell motility in metastasis, a deeper understanding of the underlying signaling pathways will be critical to translating these observations to the treatment of advanc
Externí odkaz:
https://doaj.org/article/e905f750599d4911b712a3df4fed5973
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Here the authors use optogenetic tools to directly measure spatial signal processing in leukocyte chemotaxis. Their results reveal the importance of multiple negative feedback loops for maintaining spatial information in chemotaxis.
Externí odkaz:
https://doaj.org/article/6ece3c5855d54a95807d677d7e95147c
Autor:
Amalia Hadjitheodorou, George R. R. Bell, Felix Ellett, Shashank Shastry, Daniel Irimia, Sean R. Collins, Julie A. Theriot
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Neutrophils migrate with remarkably stable front-rear polarization. Using optogenetic receptor control to induce reversal of polarization in restrictive microfluidic channels, the authors find that myosin II promotes this stability by suppressing tra
Externí odkaz:
https://doaj.org/article/9b9cbbb7074d45fe8ce70da40ca6262f
Autor:
Julie A. Theriot, Shashank Shastry, Daniel Irimia, George R. R. Bell, Sean R. Collins, Amalia Hadjitheodorou, Felix Ellett
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
To migrate efficiently to target locations, cells must integrate receptor inputs while maintaining polarity: a distinct front that leads and a rear that follows. Here we investigate what is necessary to overwrite pre-existing front-rear polarity in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c817c9e1ced86328931b4f34ed14c2
https://doaj.org/article/9b9cbbb7074d45fe8ce70da40ca6262f
https://doaj.org/article/9b9cbbb7074d45fe8ce70da40ca6262f
Autor:
Amalia Hadjitheodorou, George R. R. Bell, Felix Ellett, Daniel Irimia, Robert Tibshirani, Sean R. Collins, Julie A. Theriot
As neutrophils navigate complex environments to reach sites of infection, they may encounter obstacles that force them to split their front into multiple leading edges, raising the question of how the cell selects which front to maintain and which fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25e8ed5dc0995470f3d9b45de2379782
https://doi.org/10.1101/2022.02.21.481331
https://doi.org/10.1101/2022.02.21.481331
Autor:
Kacey VanderVorst, Courtney A. Dreyer, Jason Hatakeyama, George R. R. Bell, Anastasia L. Berg, Maria Hernandez, Hyun Lee, Sean R. Collins, Kermit L. Carraway
As evidence supporting essential roles for collective cell migration in carcinoma metastasis continues to accumulate, a better understanding of the underlying cellular and molecular mechanisms will be critical to translating these findings to the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f7b1fcd338d96e6021c96e69a3fc463
https://doi.org/10.1101/2022.01.07.475316
https://doi.org/10.1101/2022.01.07.475316
Publikováno v:
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
During chemotaxis, neutrophils use cell surface G Protein Coupled Receptors to detect chemoattractant gradients. The downstream signaling system is wired with multiple feedback loops that amplify weak inputs and promote spatial separation of cell fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321bf24315a4ee0bdb616a4fd731b279
https://doi.org/10.1101/2021.04.03.438340
https://doi.org/10.1101/2021.04.03.438340
Publikováno v:
American Malacological Bulletin. 34:40-50
Invasion of the bryozoan Membranipora membranacea to the Gulf of Maine provided an additional prey resource to the dorid nudibranch Onchidoris muricata (Muller, 1776). We examined prey choice based on past diet history and compared growth and reprodu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c5a6dc2a599e581cdfef83c9c8c7cb4
https://doi.org/10.4003/006.034.0107
https://doi.org/10.4003/006.034.0107
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1821
Neutrophils are key early responders in the innate immune response that use chemotaxis, the directed migration along chemical gradients, to reach sites of infection or inflammation. This process requires integrating inputs from cell surface receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c5f89bd33b385f125a4aa58f49b4dea
https://pubmed.ncbi.nlm.nih.gov/30062406
https://pubmed.ncbi.nlm.nih.gov/30062406
Autor:
Sean R. Collins, George R. R. Bell
Publikováno v:
Developmental cell. 46(1)
Cells migrate by applying rearward forces against extracellular media. It is unclear how this is achieved in amoeboid migration, which lacks adhesions typical of lamellipodia-driven mesenchymal migration. To address this question, we developed optoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c1d33302a0917981ca4aa614dc7e5b
https://pubmed.ncbi.nlm.nih.gov/29937389
https://pubmed.ncbi.nlm.nih.gov/29937389