Zobrazeno 1 - 10
of 21
pro vyhledávání: '"George R Marcotte"'
Autor:
George R. Marcotte, Matthew J. Miller, Hawley E. Kunz, Zachary C. Ryan, Matthew D. Strub, Patrick M. Vanderboom, Carrie J. Heppelmann, Sarah Chau, Zachary D. Von Ruff, Sean P. Kilroe, Andrew T. McKeen, Jason M. Dierdorff, Jennifer I. Stern, Karl A. Nath, Chad E. Grueter, Vitor A. Lira, Andrew R. Judge, Blake B. Rasmussen, K. Sreekumaran Nair, Ian R. Lanza, Scott M. Ebert, Christopher M. Adams
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle–specific expres
Externí odkaz:
https://doaj.org/article/af1307b64c1b4419953e38f85ed47944
Autor:
Scott M Ebert, Blake B Rasmussen, Andrew R Judge, Sarah M Judge, Lars Larsson, Ronald C Wek, Tracy G Anthony, George R Marcotte, Matthew J Miller, Mark A Yorek, Adrian Vella, Elena Volpi, Jennifer I Stern, Matthew D Strub, Zachary Ryan, John J Talley, Christopher M Adams
Publikováno v:
J Nutr
Activating transcription factor 4 (ATF4) is a multifunctional transcription regulatory protein in the basic leucine zipper superfamily. ATF4 can be expressed in most if not all mammalian cell types, and it can participate in a variety of cellular res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236e79fa0970ae2554bdf964592515da
https://doi.org/10.1093/jn/nxab440
https://doi.org/10.1093/jn/nxab440
Autor:
Matthew J. Miller, George R. Marcotte, Nathan Basisty, Cameron Wehrfritz, Zachary C. Ryan, Matthew D. Strub, Andrew T. McKeen, Jennifer I. Stern, Karl A. Nath, Blake B. Rasmussen, Andrew R. Judge, Birgit Schilling, Scott M. Ebert, Christopher M. Adams
Publikováno v:
GeroScience.
Aging slowly erodes skeletal muscle strength and mass, eventually leading to profound functional deficits and muscle atrophy. The molecular mechanisms of skeletal muscle aging are not well understood. To better understand mechanisms of muscle aging,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d8d16ffc4ee7f2111a2d8bf44695d62
https://doi.org/10.1007/s11357-023-00772-y
https://doi.org/10.1007/s11357-023-00772-y
Autor:
Daniel W. D. West, George R. Marcotte, Courtney M. Chason, Natalie Juo, Leslie M. Baehr, Sue C. Bodine, Keith Baar
Publikováno v:
Frontiers in Physiology, Vol 9 (2019)
Anabolic resistance to feeding in aged muscle is well-characterized; however, whether old skeletal muscle is intrinsically resistant to acute mechanical loading is less clear. The aim of this study was to determine the impact of aging on muscle prote
Externí odkaz:
https://doaj.org/article/bee0d0588951453db5c9be9fdb3098fc
Autor:
Nathan Basisty, Kristin C. Tomcheck, George R. Marcotte, Asma Al-Zougbi, Austin D. DeLau, Zachary P. Skopec, Jason M. Dierdorff, Jacob A. Rathmacher, Steven A. Bullard, Christopher M. Adams, Sue C. Bodine, Scott M. Ebert, Birgit Schilling
Publikováno v:
The Journal of Biological Chemistry
Skeletal muscle atrophy is a highly-prevalent and debilitating condition that remains poorly understood at the molecular level. Previous work found that aging, fasting, and immobilization promote skeletal muscle atrophy via expression of activating t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888d3abfe8657e3bf2385cc6d0ed66e5
https://doi.org/10.1074/jbc.ra119.012095
https://doi.org/10.1074/jbc.ra119.012095
Autor:
Benjamin F. Miller, Jose Alberto Lopez-Dominguez, George R. Marcotte, Megan N. Roberts, Andrea G. Marshall, Keith Baar, Marita A. Wallace, Nicholas W. Aguirre, Leslie M. Baehr, Jon J. Ramsey, David C. Hughes, Karyn L. Hamilton
Publikováno v:
Aging cell, vol 20, iss 4
Aging Cell
Aging Cell
The causes of the decline in skeletal muscle mass and function with age, known as sarcopenia, are poorly understood. Nutrition (calorie restriction) interventions impact many cellular processes and increase lifespan and preserve muscle mass and funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75376d2a02e9079d140e7a515a6ba5f
https://escholarship.org/uc/item/0ht2w36k
https://escholarship.org/uc/item/0ht2w36k
Autor:
Keith Baar, Sue C. Bodine, Andrea G. Marshall, Scott M. Ebert, Arik Davidyan, George R. Marcotte, Daniel W. D. West, Christopher M. Adams, Leslie M. Baehr, David C. Hughes
Publikováno v:
The Journal of Physiology. 596:2883-2900
Key points Force transfer is integral for maintaining skeletal muscle structure and function. One important component is dystrophin. There is limited understanding of how force transfer is impacted by age and loading. Here, we investigate the force t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff1e594137bcf0e33221f0c59a3a6b1
https://doi.org/10.1113/jp275833
https://doi.org/10.1113/jp275833
Autor:
Sue C. Bodine, Austin D. DeLau, Christopher M. Adams, George R. Marcotte, Scott M. Ebert, Asma Al-Zougbi, Kristin C. Tomcheck, David K. Meyerholz, Jason M. Dierdorff, Zachary P. Skopec, Steven A. Bullard
Publikováno v:
J Appl Physiol (1985)
Age-related skeletal muscle atrophy is a very common and serious condition that remains poorly understood at the molecular level. Several lines of evidence have suggested that the tumor suppressor p53 may play a central, causative role in skeletal mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068cfd1b176dfb08125be7d566dfd4cf
https://pubmed.ncbi.nlm.nih.gov/31465716
https://pubmed.ncbi.nlm.nih.gov/31465716
Autor:
George R. Marcotte, Luís G O de Sousa, Andrea G. Marshall, Keith Baar, Leslie M. Baehr, Sue C. Bodine, Daniel W. D. West
Publikováno v:
Aging, vol 8, iss 1
Aging (Albany NY)
Aging (Albany NY)
Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d8f58ed04579859ee9834a4b4eac1a
https://doi.org/10.18632/aging.100879
https://doi.org/10.18632/aging.100879
Autor:
George R. Marcotte, Courtney M. Chason, Daniel W. D. West, Sue C. Bodine, Aldrin V. Gomes, Luis Tolento, Leslie M. Baehr, Keith Baar
Publikováno v:
The Journal of Physiology. 594:453-468
Author(s): West, Daniel WD; Baehr, Leslie M; Marcotte, George R; Chason, Courtney M; Tolento, Luis; Gomes, Aldrin V; Bodine, Sue C; Baar, Keith | Abstract: Key pointsRibosome biogenesis is the primary determinant of translational capacity, but its re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9e11ff40c7f5711841836d3e96f751d
https://doi.org/10.1113/jp271365
https://doi.org/10.1113/jp271365