Zobrazeno 1 - 10
of 90
pro vyhledávání: '"George R Bousfield"'
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137897 (2015)
The gonadotropin known as follicle-stimulating hormone (FSH) plays a key role in regulating reproductive processes. Physiologically active FSH is a glycoprotein that can accommodate glycans on up to four asparagine residues, including two sites in th
Externí odkaz:
https://doaj.org/article/af59190077be447a9efc82264a447792
Autor:
Viktor Y. Butnev, Jeffrey V. May, Alan R. Brown, Tarak Sharma, Vladimir Y. Butnev, William K. White, David J. Harvey, George R. Bousfield
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Follicle-stimulating hormone (FSH), an α/β heterodimeric glycoprotein hormone, consists of functionally significant variants resulting from the presence or absence of either one of two FSHβ subunit N-glycans. The two most abundant variants are ful
Externí odkaz:
https://doaj.org/article/65e5a5b4f54b4fa0b40688d3cc45d7e8
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 9020 (2023)
Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining moment in our understanding
Externí odkaz:
https://doaj.org/article/ed4c11dd8c02496cb5ea9ff9a4bc4e11
Autor:
Uchechukwu T. Agwuegbo, Emily Colley, Anthony P. Albert, Viktor Y. Butnev, George R. Bousfield, Kim C. Jonas
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive in vitro and in vivo
Externí odkaz:
https://doaj.org/article/0be72419f62b4829957f4e9975955289
Autor:
Haley R. Blum, Jeffrey V. May, Alan Brown, Gillian P. Johnson, Guohua Hua, Viktor Y. Butnev, Jitu W. George, Sahithi Katta, John S. Davis, Chittibabu Guda, Xiaoying Hou, Kendra L. Clark, Siddesh Southekal, Kim Jonas, James D. Eudy, George R. Bousfield
Publikováno v:
Hum Reprod
STUDY QUESTION Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)? SUMMARY ANSWER Compared with fully-glycos
Autor:
Gillian P Johnson, Caitlan G A Onabanjo, Kate Hardy, Viktor Y Butnev, George R Bousfield, Kim C Jonas
Publikováno v:
Johnson, G P, Onabanjo, C G A, Hardy, K, Butnev, V Y, Bousfield, G R & Jonas, K C 2022, ' Follicle stimulating hormone glycosylation variants distinctly modulate pre-antral follicle growth and survival ', Endocrinology, vol. 163, no. 12 . https://doi.org/10.1210/endocr/bqac161
Follicle-stimulating hormone (FSH) is a key endocrine regulator of ovarian function. FSH is secreted as 2 macroglycosylation variants: partially glycosylated FSH (FSH21/18) and fully glycosylated FSH (FSH24). FSH21/18 is more potent than FSH24 at bin
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1635-1640 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Highlights • Routinely generated glycan data on reproductive system need systematic storage, ease of access, and data integration. • Currently, no database stores information on glycans associated with reproductive hormone
Highlights • Routinely generated glycan data on reproductive system need systematic storage, ease of access, and data integration. • Currently, no database stores information on glycans associated with reproductive hormone
Publikováno v:
Reproduction
Female reproductive aging is characterized by a rise in follicle-stimulating hormone (FSH) levels during peri-menopause. N-linked glycans are co-translationally attached to the Asn7 and Asn24 residues on the FSHβ subunit. Differences in the number o
Publikováno v:
Endocrine Abstracts.
Autor:
George Barisas, Duaa Althumairy, Nicholas Baez, Deborah A. Roess, Xiaoping Zhang, Debbie C. Crans, George R. Bousfield
Publikováno v:
Diseases
Diseases, Vol 8, Iss 35, p 35 (2020)
Diseases, Vol 8, Iss 35, p 35 (2020)
Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating hormone receptors (FSHRs) is essential for the successful reproduction of human beings. Both receptors and the thyroid-stimulating hormone receptor are members of a