Zobrazeno 1 - 3
of 3
pro vyhledávání: '"George R, Tonn"'
Autor:
Daniel C-H Lin, Jane Zhang, Run Zhuang, Frank Li, Kathy Nguyen, Michael Chen, Thanhvien Tran, Edwin Lopez, Jenny Ying Lin Lu, Xiaoyan Nina Li, Liang Tang, George R Tonn, Gayathri Swaminath, Jeff D Reagan, Jin-Long Chen, Hui Tian, Yi-Jyun Lin, Jonathan B Houze, Jian Luo
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27270 (2011)
Agonists of GPR40 (FFA1) have been proposed as a means to treat type 2 diabetes. Through lead optimization of a high throughput screening hit, we have identified a novel GPR40 agonist called AMG 837. The objective of these studies was to understand t
Externí odkaz:
https://doaj.org/article/729ea24e76304c709713d2c9927fb903
Autor:
Patrick S. Lee, Guillaume Lapointe, Ann Marie Madera, Robert L. Simmons, Wenjian Xu, Aregahegn Yifru, Meiliana Tjandra, Subramanian Karur, Alice Rico, Katherine Thompson, Jade Bojkovic, Lili Xie, Kyoko Uehara, Amy Liu, Wei Shu, Cornelia Bellamacina, David McKenney, Laura Morris, George R. Tonn, Colin Osborne, Bret M. Benton, Laura McDowell, Jiping Fu, Zachary K. Sweeney
Publikováno v:
Journal of medicinal chemistry. 61(20)
This report summarizes the identification and synthesis of novel LpxC inhibitors aided by computational methods that leveraged numerous crystal structures. This effort led to the identification of oxazolidinone and isoxazoline inhibitors with potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade1f58c704f5b522b1f39fc2181a0e2
https://pubmed.ncbi.nlm.nih.gov/30226381
https://pubmed.ncbi.nlm.nih.gov/30226381
Autor:
George R, Tonn, Simon G, Wong, Sylvia C, Wong, Michael G, Johnson, Ji, Ma, Robert, Cho, Leslie C, Floren, Kathryn, Kersey, Karen, Berry, Andrew P, Marcus, Xuemei, Wang, Bettina, Van Lengerich, Julio C, Medina, Paul G, Pearson, Bradley K, Wong
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 37(3)
(R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]-pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxyphenyl)-acetamide (AMG 487) is a potent and selective orally bioavailable chemokine (C-X-C motif) receptor 3 (CXCR3) antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2f9dbbe66e4e45e13bc1d5a184766fc
https://pubmed.ncbi.nlm.nih.gov/19088267
https://pubmed.ncbi.nlm.nih.gov/19088267