Zobrazeno 1 - 10
of 763
pro vyhledávání: '"George R, Pettit"'
Publikováno v:
Archives of Biochemistry and Biophysics. 730:109412
Publikováno v:
Archives of Biochemistry and Biophysics. 727:109296
A tritiated derivative of the sponge-derived natural product spongistatin 1 was prepared, and its interactions with tubulin were examined. [
Publikováno v:
Journal of natural products. 83(5)
The remarkable biological activity of the dolastatin 10 structural modifications quinstatins and isoquinstatins prompted further investigation into drug hybrids containing biologically active isoquinoline moieties. In this study, the isoquinoline alk
Publikováno v:
Journal of Natural Products. 81:451-457
In order to further explore quinoline-type structural modification of the powerful anticancer drug dolastatin 10, an Indian Ocean sea hare constituent and parent molecule of the very successful antibody drug conjugate (ADC) Adcetris, our recent quins
Publikováno v:
Journal of Natural Products. 80:692-698
Discovery of the exceptionally powerful anticancer drug dolastatin 10 (1), contained in the sea hare Dolabella auricularia, opened a new frontier needed for improving human cancer treatment. Subsequently, major advances have been achieved based on re
Autor:
John C. Knight, George R. Pettit, Noeleen Melody, Jean-Charles Chapuis, Justin Searcy, Gordon M. Cragg, Rui Tan
Publikováno v:
Journal of Natural Products. 79:507-518
Cytotoxic constituents of the terrestrial plant Bridelia ferruginea were isolated using bioactivity-guided fractionation, which revealed the presence of the previously known deoxypodophyllotoxin (1), isopicrodeoxypodophyllotoxin (2), β-peltatin (3),
Publikováno v:
Arch Biochem Biophys
[(3)H]Diazonamide A ([(3)H]DZA), prepared from the natural product isolated from Diazona angulata, bound to tubulin in larger aberrant assembly products (> 500 kDa by sizing HPLC) but not to the α,β-tubulin heterodimer. The binding reaction was rap
Publikováno v:
Journal of natural products. 81(3)
The medicinal potential of the plant pentacyclic triterpene betulin has generated long-term interest focused on various SAR research avenues. The present approach was based on producing further analogues (chimeras) arising from a studied modification
Publikováno v:
Journal of Natural Products. 78:1446-1450
For the purpose of advancing knowledge of the structural variations available in the natural cephalostatins contained in the marine worm Cephalodiscus gilchristi, the isolation and structure of the 20th member (1) has been accomplished (10(-7) % yiel
Autor:
Xing Zheng, John C. Knight, Delbert L. Herald, Bryan R. Moser, George R. Pettit, Jean-Charles Chapuis
Publikováno v:
Journal of Natural Products. 78:1067-1072
Cephalostatin 1 (1) has proved to be a remarkably potent cancer cell growth inhibitor. Since this steroidal alkaloid constituent of the marine worm Cephalodiscus gilchristi possesses a complex structure, providing preclinical supplies by total synthe