Zobrazeno 1 - 10
of 42
pro vyhledávání: '"George R, Heath"'
Autor:
Sabine M. Ulamec, Roberto Maya-Martinez, Emily J. Byrd, Katherine M. Dewison, Yong Xu, Leon F. Willis, Frank Sobott, George R. Heath, Patricija van Oosten Hawle, Vladimir L. Buchman, Sheena E. Radford, David J. Brockwell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors of this work characterize the effect of amino acid substitution on α-synuclein (α-Syn) aggregation. Residues 38 and 42 (in addition to 39) within the P1 region of α-Syn affect amyloid formation. The effect of substitution at position 3
Externí odkaz:
https://doaj.org/article/795dea3b15b941688aa5f281361c1332
Autor:
Yong Xu, Roberto Maya-Martinez, Nicolas Guthertz, George R. Heath, Iain W. Manfield, Alexander L. Breeze, Frank Sobott, Richard Foster, Sheena E. Radford
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here the authors carry out chemical kinetic studies revealing that aggregation of hIAPP and its variant S20G involves secondary nucleation. Two small molecules with novel scaffolds are shown to inhibit or accelerate aggregation by binding different m
Externí odkaz:
https://doaj.org/article/d21098cc865040188a3674711bd2d77e
Autor:
Raghavendar Reddy Sanganna Gari, Joel José Montalvo‐Acosta, George R. Heath, Yining Jiang, Xiaolong Gao, Crina M. Nimigean, Christophe Chipot, Simon Scheuring
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
High-speed atomic force microscopy height spectroscopy and single channel electrophysiology recordings are used to correlate conformational and functional dynamics of the model membrane protein, outer membrane protein G (OmpG). These techniques show
Externí odkaz:
https://doaj.org/article/244843fefff4420181bab8bb8e548a7e
Autor:
Francis R. Hopkins, Beatriz Álvarez-Rodríguez, George R. Heath, Kyriakoulla Panayi, Samantha Hover, Thomas A. Edwards, John N. Barr, Juan Fontana
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The Bunyavirales order is the largest group of negative-sense RNA viruses, containing many lethal human pathogens for which approved anti-infective measures are not available. The bunyavirus genome consists of multiple negative-sense RNA seg
Externí odkaz:
https://doaj.org/article/ca0a31a995f34aa189f26897e51a0d34
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Excitatory amino acid transporters (EAATs) are crucial for the removal of excitatory amino acids from the synaptic cleft. Here authors combined high-speed atomic force microscopy line-scanning with automated state assignment for the determination of
Externí odkaz:
https://doaj.org/article/c95aa1629c334ed0810a6e777c977f72
Autor:
George R. Heath, Simon Scheuring
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The dynamics of biomolecules can occur over a wide range of time and length scales. Here the authors develop a high-speed AFM height spectroscopy method to directly detect the motion of unlabeled molecules at Angstrom spatial and microsecond temporal
Externí odkaz:
https://doaj.org/article/10b963554d2e41b2b5ae312445bcf43c
Autor:
Hayden Burdett, Martina Foglizzo, Laura J. Musgrove, Dhananjay Kumar, Gillian Clifford, Lisa J. Campbell, George R. Heath, Elton Zeqiraj, Marcus D. Wilson
Chromatin association of the BRCA1-BARD1 heterodimer is critical to promote homologous recombination repair of DNA double-strand breaks (DSBs) in S/G2. How the BRCA1-BARD1 complex interacts with chromatin that contains both damage induced histone H2A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93e34e10779b1e9b60372afd5412b072
https://doi.org/10.1101/2023.03.28.533771
https://doi.org/10.1101/2023.03.28.533771
Autor:
Xiaolong Gao, George R. Heath, Raghavendar Reddy Sanganna Gari, Simon Scheuring, Crina M. Nimigean, Christophe Chipot, Yining Jiang, Joel José Montalvo‐Acosta
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Conformational changes in ion channels lead to gating of an ion-conductive pore. Ion flux has been measured with high temporal resolution by single-channel electrophysiology for decades. However, correlation between functional and conformational dyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c438695a37c6e09ce424077aca3399fb
https://doaj.org/article/244843fefff4420181bab8bb8e548a7e
https://doaj.org/article/244843fefff4420181bab8bb8e548a7e
Autor:
Shifra Lansky, Ekaterina Kots, Simon Scheuring, Janice L. Robertson, George Khelashvili, George R. Heath, Harel Weinstein
Publikováno v:
Nature. 594:385-390
Understanding structural dynamics of biomolecules at the single-molecule level is vital to advancing our knowledge of molecular mechanisms. Currently, there are few techniques that can capture dynamics at the sub-nanometre scale and in physiologicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40ad75450ca4a2a44a7193cc617a4d2f
https://doi.org/10.1038/s41586-021-03551-x
https://doi.org/10.1038/s41586-021-03551-x
Autor:
Sabine M, Ulamec, Roberto, Maya-Martinez, Emily J, Byrd, Katherine M, Dewison, Yong, Xu, Leon F, Willis, Frank, Sobott, George R, Heath, Patricija, van Oosten Hawle, Vladimir L, Buchman, Sheena E, Radford, David J, Brockwell
Publikováno v:
Nature communications. 13(1)
Alpha-synuclein (αSyn) is a protein involved in neurodegenerative disorders including Parkinson's disease. Amyloid formation of αSyn can be modulated by the 'P1 region' (residues 36-42). Here, mutational studies of P1 reveal that Y39A and S42A exte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89b1e3ae3e24b7c969295b86ef771ad4
https://pubmed.ncbi.nlm.nih.gov/36008493
https://pubmed.ncbi.nlm.nih.gov/36008493