Zobrazeno 1 - 10
of 24
pro vyhledávání: '"George R, Gunn"'
Autor:
Karen Liao, Keguan Chen, Sara Brett, Andrew Gehman, Ann M Schwartz, George R Gunn, Stephen L DeWall
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249049 (2021)
Interleukin-7 (IL-7) signaling modulates T cell activity and is implicated in numerous autoimmune diseases. An anti-IL-7 receptor monoclonal antibody (GSK2618960) biotherapeutic was evaluated in healthy subjects for safety, pharmacokinetics (PK), pha
Externí odkaz:
https://doaj.org/article/788236ade2a64347a34ce69e5cadabb4
Simple method to determine the concentration and incorporation ratio of ruthenium-labeled antibodies
Publikováno v:
Bioanalysis. 14:19-28
Aim: Ruthenium-labeled antibodies are commonly used detection reagents in bioanalysis assays and must be characterized to ensure quality. The aim of this work was to develop a method to determine the concentration and incorporation ratio (the degree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5116edfcb489fad78df01e88839d6d5
https://doi.org/10.4155/bio-2021-0197
https://doi.org/10.4155/bio-2021-0197
Autor:
Swati Gupta, Sylvie Bertholet, Daniela Verthelyi, Jason Delcarpini, George R Gunn, Richard Siggers, Anna Ma, Fabio Garofolo, Lisa Kierstead, Mark Milton, Francis Dessy, Johann Poetzl, Arno Kromminga, Boris Gorovits, Marco Petrillo, Madeleine Dahlbäck, Lynne Jesaitis, Robert J Kubiak, Becky Schweighardt, Mohsen Rajabi Abhari, Kay Stubenrauch, Meina Liang, Yanmei Lu, Susan Kirshner, Haoheng Yan, John Kamerud, Rocio Murphy, Naveen Dakappagari, Holger Koch, Akiko Ishii-Watabe, Yuanxin Xu, Sam Song, Michael A Partridge, Lucia Zhang, Chris Stebbins, Vibha Jawa, Andrew Exley, Elana Cherry, Jim McNally, Manoj Rajadhyaksha, Bart Corsaro, Bonnie Wu, Therese Solstad, Jean-Claude Marshall, Isabelle Cludts, Ivo Sonderegger, Sumit Kar, Tong-Yuan Yang, Roland F Staack, João Pedras-Vasconcelos, Natasha Savoie, Yuling Wu, Samuel O. Pine, Ghanashyam Sarikonda
Publikováno v:
Bioanalysis. 13:415-463
The 14th edition of the Workshop on Recent Issues in Bioanalysis (14th WRIB) was held virtually on June 15-29, 2020 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78dad76399423931f3bb96a1903bd264
https://doi.org/10.4155/bio-2021-0007
https://doi.org/10.4155/bio-2021-0007
Publikováno v:
Analytical Biochemistry. 664:115033
Degree of labeling and label efficiency are key factors for optimal characterization of critical reagents that are used in ligand binding assays. Here, three case studies are shown demonstrating how liquid chromatography-mass spectrometry (LC-MS) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5543fdb8daf894995ca12c6a40dd1a23
https://doi.org/10.1016/j.ab.2022.115033
https://doi.org/10.1016/j.ab.2022.115033
Autor:
Jim McNally, Szilárd Kamondi, Daniel Kramer, Honglue Shen, Vibha Jawa, Jane Ruppel, Charles S Hottenstein, Kelli R. Phillips, Meina Liang, Michael E Hodsdon, Dong Geng, Joanne Goodman, Mohsen Rajabi Ahbari, Heather Myler, Marta Starcevic Manning, Alvydas Mikulskis, William Hallett, Haoheng Yan, Adrienne Clements-Egan, Paul Chamberlain, Qiang Qu, ZhenZhen Liu, Carol Gleason, Viswanath Devanaryan, George R Gunn, Susan M. Richards, Theresa J Goletz, Troy E. Barger, Susana Liu, Lakshmi Amaravadi, Veerle Snoeck, Joao Pedras-Vasconcelos, Kathryn Lindley, Robert Nelson, Mark Ware, Shobha Purushothama, An Song, Susan Kirshner, Brian M Janelsins, Jad Zoghbi, Steven Bowen, Ronald R. Bowsher
Publikováno v:
The AAPS Journal. 24
Evolving immunogenicity assay performance expectations and a lack of harmonized anti-drug antibody validation testing and reporting tools have resulted in significant time spent by health authorities and sponsors on resolving filing queries. Followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bacf181ab0fa77b1607ce8395bb2e0
https://doi.org/10.1208/s12248-021-00649-y
https://doi.org/10.1208/s12248-021-00649-y
Autor:
Stephen DeWall, Sara Brett, Keguan Chen, Andrew Gehman, George R Gunn, Ann M. Schwartz, Karen Liao
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0249049 (2021)
PLoS ONE, Vol 16, Iss 3, p e0249049 (2021)
Interleukin-7 (IL-7) signaling modulates T cell activity and is implicated in numerous autoimmune diseases. An anti-IL-7 receptor monoclonal antibody (GSK2618960) biotherapeutic was evaluated in healthy subjects for safety, pharmacokinetics (PK), pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02991f95e477619c171344bf158bfb80
http://europepmc.org/articles/PMC7987154
http://europepmc.org/articles/PMC7987154
Autor:
Bart, Corsaro, Tong-Yuan, Yang, Rocio, Murphy, Ivo, Sonderegger, Andrew, Exley, Sylvie, Bertholet, Naveen, Dakappagari, Francis, Dessy, Fabio, Garofolo, Lisa, Kierstead, Holger, Koch, Ghanashyam, Sarikonda, Natasha, Savoie, Richard, Siggers, Therese, Solstad, Yanmei, Lu, Mark, Milton, Jean-Claude, Marshall, Jason, DelCarpini, Boris, Gorovits, Swati, Gupta, Lynne, Jesaitis, John, Kamerud, Arno, Kromminga, Anna, Ma, Jim, McNally, Haoheng, Yan, Bonnie, Wu, Daniela, Verthelyi, Susan, Kirshner, Joao, Pedras-Vasconcelos, Manoj, Rajadhyaksha, Roland F, Staack, Elana, Cherry, Isabelle, Cludts, Madeleine, Dahlbäck, George R, Gunn, Akiko, Ishii-Watabe, Vibha, Jawa, Robert, Kubiak, Michael, Partridge, Marco, Petrillo, Samuel O, Pine, Johann, Poetzl, Sam, Song, Chris, Stebbins, Yuling, Wu, Lucia, Zhang, Sumit, Kar, Meina, Liang, Mohsen Rajabi, Abhari, Becky, Schweighardt, Kay, Stubenrauch, Yuanxin, Xu
Publikováno v:
Bioanalysis. 13(6)
The 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40e211e9d228d8f55e8aa54ba0385b30
https://pubmed.ncbi.nlm.nih.gov/33533276
https://pubmed.ncbi.nlm.nih.gov/33533276
Autor:
Adrienne Clements-Egan, Binodh DeSilva, Viswanath Devanarayan, Boris Gorovits, George R. Gunn, Vinod P. Shah, Kelli R. Phillips, Susan Kirshner, Heather Myler
Publikováno v:
The AAPS Journal. 21
In September 2018, the American Association of Pharmaceutical Scientists (AAPS) conducted an Annual Guidance Forum on the considerations related to immunogenicity testing for therapeutic protein products. In addition to a broad representation by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09c5e535f432b4e29687662b3186436
https://doi.org/10.1208/s12248-019-0328-8
https://doi.org/10.1208/s12248-019-0328-8
Autor:
David C.F. Sealey, Subrata Ghosh, Fakhreddin Jamali, Gopi Shankar, George R. Gunn, Bernd Meibohm
Publikováno v:
Clinical and Experimental Immunology. 184:137-146
Summary Unlike conventional chemical drugs where immunogenicity typically does not occur, the development of anti-drug antibodies following treatment with biologics has led to concerns about their impact on clinical safety and efficacy. Hence the elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fb5dc0a9f3d8e52966c950797c6076
https://doi.org/10.1111/cei.12742
https://doi.org/10.1111/cei.12742
Autor:
George R Gunn, Zhenhua Xu, Omoniyi J. Adedokun, Cynthia Gargano, Jocelyn H. Leu, Paul Rutgeerts, William J. Sandborn, Gopi Shankar
Publikováno v:
Inflammatory bowel diseases. 25(9)
Background Antidrug antibody (ADA) detection with standard bridging enzyme immunoassays (EIA) can yield false-negative results or underestimate titers through drug interference. A more sensitive assay was needed to determine clinical impact of antigo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8307745b1042f83f10852543199f4776
https://pubmed.ncbi.nlm.nih.gov/30753466
https://pubmed.ncbi.nlm.nih.gov/30753466