Zobrazeno 1 - 10
of 543
pro vyhledávání: '"George Q. Daley"'
Autor:
Tianyu Tan, Bo Gao, Hua Yu, Hongru Pan, Zhen Sun, Anhua Lei, Li Zhang, Hengxing Lu, Hao Wu, George Q. Daley, Yu Feng, Jin Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract LIN28A is important in somatic reprogramming and pluripotency regulation. Although previous studies addressed that LIN28A can repress let-7 microRNA maturation in the cytoplasm, few focused on its role within the nucleus. Here, we show that
Externí odkaz:
https://doaj.org/article/53c6d0779a1f4b76ac7eb79679ef83b6
Autor:
Hua Yu, Zhen Sun, Tianyu Tan, Hongru Pan, Jing Zhao, Ling Zhang, Jiayu Chen, Anhua Lei, Yuqing Zhu, Lang Chen, Yuyan Xu, Yaxin Liu, Ming Chen, Jinghao Sheng, Zhengping Xu, Pengxu Qian, Cheng Li, Shaorong Gao, George Q. Daley, Jin Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
The role of the nucleolus in cell fate is not well known. Here the authors show nucleolar integrity maintained by rRNA-mediated liquid-liquid phase separation and 3D chromatin structure of perinucleolar heterochromatin regulates the fate transition o
Externí odkaz:
https://doaj.org/article/24ed821a05d7423a843829e3bb8e0f2c
Autor:
Josefine Tratwal, Guillaume Falgayrac, Alexandrine During, Nicolas Bertheaume, Charles Bataclan, Daniel N. Tavakol, Vasco Campos, Ludovic Duponchel, George Q. Daley, Guillaume Penel, Christophe Chauveau, Olaia Naveiras
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Bone marrow adipocytes (BMAds) constitute the most abundant stromal component of adult human bone marrow. Two subtypes of BMAds have been described, the more labile regulated adipocytes (rBMAds) and the more stable constitutive adipocytes (cBMAds), w
Externí odkaz:
https://doaj.org/article/4902e5f201334c0e8c7482fd57750abb
Autor:
Mohamed Abou-el-Enein, Aris Angelis, Frederick R. Appelbaum, Nancy C. Andrews, Susan E. Bates, Arlene S. Bierman, Malcolm K. Brenner, Marina Cavazzana, Michael A. Caligiuri, Hans Clevers, Emer Cooke, George Q. Daley, Victor J. Dzau, Lee M. Ellis, Harvey V. Fineberg, Lawrence S.B. Goldstein, Stephen Gottschalk, Margaret A. Hamburg, Donald E. Ingber, Donald B. Kohn, Adrian R. Krainer, Marcela V. Maus, Peter Marks, Christine L. Mummery, Roderic I. Pettigrew, Joni L. Rutter, Sarah A. Teichmann, Andre Terzic, Fyodor D. Urnov, David A. Williams, Jedd D. Wolchok, Mark Lawler, Cameron J. Turtle, Gerhard Bauer, John P.A. Ioannidis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 11-14 (2021)
Externí odkaz:
https://doaj.org/article/c3fa45c6e32349f68ffd7fcab701dc16
Autor:
Dahai Wang, Mayuri Tanaka-Yano, Eleanor Meader, Melissa A. Kinney, Vivian Morris, Edroaldo Lummertz da Rocha, Nan Liu, Tianxin Liu, Qian Zhu, Stuart H. Orkin, Trista E. North, George Q. Daley, R. Grant Rowe
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110587- (2022)
Summary: Hematopoiesis changes over life to meet the demands of maturation and aging. Here, we find that the definitive hematopoietic stem and progenitor cell (HSPC) compartment is remodeled from gestation into adulthood, a process regulated by the h
Externí odkaz:
https://doaj.org/article/a3c71faa5bb64419ab9cc810a7891658
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
Autor:
Joseph W. Franses, Julia Philipp, Pavlos Missios, Irun Bhan, Ann Liu, Chittampalli Yashaswini, Eric Tai, Huili Zhu, Matteo Ligorio, Benjamin Nicholson, Elizabeth M. Tassoni, Niyati Desai, Anupriya S. Kulkarni, Annamaria Szabolcs, Theodore S. Hong, Andrew S. Liss, Carlos Fernandez-del Castillo, David P. Ryan, Shyamala Maheswaran, Daniel A. Haber, George Q. Daley, David T. Ting
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Metastatic dissemination contributes to the lethality in pancreatic ductal adenocarcinoma (PDAC). Here, the authors perform RNA-sequencing on patient derived circulating tumor cells (CTCs) and identify three major CTC subgroups, and show the therapeu
Externí odkaz:
https://doaj.org/article/8bd6be3bfdd24c5bb956606bf62f9ee0
Autor:
Alena V. Yermalovich, Jihan K. Osborne, Patricia Sousa, Areum Han, Melissa A. Kinney, Michael J. Chen, Daisy A. Robinton, Helen Montie, Dan S. Pearson, Sean B. Wilson, Alexander N. Combes, Melissa H. Little, George Q. Daley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nephrogenesis ceases after postnatal day 2 in the mouse or after the 36th week of gestation in humans, but how this is regulated is unclear. Here, the authors identify a role for the RNA-binding protein Lin28 and suppression of let-7 microRNA in regu
Externí odkaz:
https://doaj.org/article/67ffa389fabd4131821bc10193d477ff
Autor:
Carla Lopes, Yang Tang, Sandra I. Anjo, Bruno Manadas, Isabel Onofre, Luís P. de Almeida, George Q. Daley, Thorsten M. Schlaeger, Ana Cristina Carvalho Rego
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mitochondrial deregulation has gained increasing support as a pathological mechanism in Huntington’s disease (HD), a genetic-based neurodegenerative disorder caused by CAG expansion in the HTT gene. In this study, we thoroughly investigated mitocho
Externí odkaz:
https://doaj.org/article/034c49801e4a46ddac39a80d660201f9
Autor:
Edroaldo Lummertz da Rocha, R. Grant Rowe, Vanessa Lundin, Mohan Malleshaiah, Deepak Kumar Jha, Carlos R. Rambo, Hu Li, Trista E. North, James J. Collins, George Q. Daley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Single cell analysis provides insight into cell states and transitions, but to interpret the data, improved algorithms are needed. Here, the authors present CellRouter as a method to analyse single-cell trajectories from RNA-sequencing data, and prov
Externí odkaz:
https://doaj.org/article/a6f7ea0f1a01485c910f1c2cda66c406
Autor:
Sriram Chandrasekaran, Jin Zhang, Zhen Sun, Li Zhang, Christian A. Ross, Yu-Chung Huang, John M. Asara, Hu Li, George Q. Daley, James J. Collins
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2965-2977 (2017)
Summary: Metabolism is an emerging stem cell hallmark tied to cell fate, pluripotency, and self-renewal, yet systems-level understanding of stem cell metabolism has been limited by the lack of genome-scale network models. Here, we develop a systems a
Externí odkaz:
https://doaj.org/article/12012fd51a0043a1aa8fdde6efdb0515