Výsledky vyhledávání - "George Plitas"

Akademický článek

Preoperative immune checkpoint inhibition and cryoablation in early-stage breast cancer

Autor: Elizabeth Comen, Sadna Budhu, Yuval Elhanati, David Page, Teresa Rasalan-Ho, Erika Ritter, Phillip Wong, George Plitas, Sujata Patil, Edi Brogi, Maxine Jochelson, Yolanda Bryce, Stephen B. Solomon, Larry Norton, Taha Merghoub, Heather L. McArthur

Publikováno v: iScience, Vol 27, Iss 2, Pp 108880- (2024)

Summary: Local cryoablation can engender systemic immune activation/anticancer responses in tumors otherwise resistant to immune checkpoint blockade (ICB). We evaluated the safety/tolerability of preoperative cryoablation plus ipilimumab and nivoluma

Externí odkaz: https://doaj.org/article/3872ec444cc0468d9d5b8ed7958953e2

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Akademický článek

Opioids and immune checkpoint inhibitors differentially regulate a common immune network in triple-negative breast cancer

Autor: Joseph R. Scarpa, Giacomo Montagna, George Plitas, Amitabh Gulati, Gregory W. Fischer, Joshua S. Mincer

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

BackgroundOpioids are the primary analgesics for cancer pain. Recent clinical evidence suggests opioids may counteract the effect of immune checkpoint inhibition (ICI) immunotherapy, but the mechanism for this interaction is unknown. The following ex

Externí odkaz: https://doaj.org/article/a6bede7dc3a54902a6ef190e48d7c203

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Akademický článek

Poor response to neoadjuvant chemotherapy in metaplastic breast carcinoma

Autor: Willard Wong, Edi Brogi, Jorge S. Reis-Filho, George Plitas, Mark Robson, Larry Norton, Monica Morrow, Hannah Y. Wen

Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)

Abstract Metaplastic breast carcinoma (MpBC) is a rare special histologic subtype of breast carcinoma characterized by the presence of squamous and/or mesenchymal differentiation. Most MpBCs are of triple-negative phenotype and neoadjuvant chemothera

Externí odkaz: https://doaj.org/article/dfb94e25ff8d460f8dd36265079a5e88

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Akademický článek

Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

There is an unmet clinical need for simple, accessible biomarkers to select patients who are more likely to respond to immune checkpoint therapy. Here the authors show that a lower neutrophil-to-lymphocyte ratio is associated with better overall and

Externí odkaz: https://doaj.org/article/dd218269962540ee8add1e4fa781b7e2

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Akademický článek

Enhancing mucosal immunity by transient microbiota depletion

Autor: Simone Becattini, Eric R. Littmann, Ruth Seok, Luigi Amoretti, Emily Fontana, Roberta Wright, Mergim Gjonbalaj, Ingrid M. Leiner, George Plitas, Tobias M. Hohl, Eric G. Pamer

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Tissue resident CD8 + T cells present at mucosal surfaces are poised to elicit function in situ, however approaches to boost their number in the gastrointestinal mucosa has been limited. Here the authors combine the use of Listeria monocytogenese and

Externí odkaz: https://doaj.org/article/9cddbe7fed714fe98fcf6304ce6172f0

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Akademický článek

Genetic and epigenetic variation in the lineage specification of regulatory T cells

Autor: Aaron Arvey, Joris van der Veeken, George Plitas, Stephen S Rich, Patrick Concannon, Alexander Y Rudensky

Publikováno v: eLife, Vol 4 (2015)

Regulatory T (Treg) cells, which suppress autoimmunity and other inflammatory states, are characterized by a distinct set of genetic elements controlling their gene expression. However, the extent of genetic and associated epigenetic variation in the

Externí odkaz: https://doaj.org/article/9f7a3b8dce3c43e5ad7262d193f409af

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