Zobrazeno 1 - 10
of 162
pro vyhledávání: '"George Panayotou"'
Autor:
Katerina Karkali, Samuel W. Vernon, Richard A. Baines, George Panayotou, Enrique Martín-Blanco
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we
Externí odkaz:
https://doaj.org/article/b866f92b75464a13a267f89280a79503
Autor:
Patrícia A. Gomes, Cristian Bodo, Carlos Nogueras-Ortiz, Martina Samiotaki, Minghao Chen, Carina Soares-Cunha, Joana M. Silva, Bárbara Coimbra, George Stamatakis, Liliana Santos, George Panayotou, Foteini Tzouanou, Clarissa L. Waites, Christos Gatsogiannis, Nuno Sousa, Dimitrios Kapogiannis, Bruno Costa-Silva, Ioannis Sotiropoulos
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Extracellular vesicles (EVs), including small EVs (sEVs) such as exosomes, exhibit great potential for the diagnosis and treatment of brain disorders, representing a valuable tool for precision medicine. The latter demands high-qu
Externí odkaz:
https://doaj.org/article/1b9f0ce8293249e8b5b641bda464ebec
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The shape and size of the mature central nervous system is highly regular, implying precise architectural rules. The authors show that alterations in JNK signaling in selected neurons impact the overall 3-dimensional organization of the Drosophila ve
Externí odkaz:
https://doaj.org/article/1cf7f66382af4d7d85478b20b4b0f74c
Autor:
Athanasios Armakolas, Vasiliki Dimopoulou, Adrianos Nezos, George Stamatakis, Martina Samiotaki, George Panayotou, Maria Tampaki, Martha Stathaki, Spyridon Dourakis, John Koskinas
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 10, Pp 4714-4734 (2022)
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. Early detection/diagnosis is vital for the prognosis of HCC, whereas diagnosis at late stages is associated with very low survival rate. Early diagnosis is based on 6-
Externí odkaz:
https://doaj.org/article/a9245a65e74c4870be8c3f5c85c1911e
Autor:
Nasia Antoniou, Kanella Prodromidou, Georgia Kouroupi, Ioanna Boumpoureka, Martina Samiotaki, George Panayotou, Maria Xilouri, Ismini Kloukina, Leonidas Stefanis, Regis Grailhe, Era Taoufik, Rebecca Matsas
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract Combining high throughput screening approaches with induced pluripotent stem cell (iPSC)-based disease modeling represents a promising unbiased strategy to identify therapies for neurodegenerative disorders. Here we applied high content imag
Externí odkaz:
https://doaj.org/article/cea8d1232e85465989ceec532c924bc4
Autor:
Kreon Koukoulas, Antonis Giakountis, Angeliki Karagiota, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3468-3489 (2021)
The hypoxia‐inducible factor HIF‐1 is essential for oxygen homeostasis. Despite its well‐understood oxygen‐dependent expression, regulation of its transcriptional activity remains unclear. We show that phosphorylation by extracellular signal
Externí odkaz:
https://doaj.org/article/96b5fdc018014ecb9f0b7ff7a70f7dfc
Autor:
Chrysa Taze, Sotiria Drakouli, Martina Samiotaki, George Panayotou, George Simos, Eleni Georgatsou, Ilias Mylonis
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102545- (2022)
The cellular response to hypoxia, in addition to HIF-dependent transcriptional reprogramming, also involves less characterized transcription-independent processes, such as alternative splicing of the VEGFA transcript leading to the production of the
Externí odkaz:
https://doaj.org/article/c2aac6436ca34230b1d797e213c692b8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Metabolism comprises of two axes in order to serve homeostasis: anabolism and catabolism. Both axes are interbranched with the so-called bioenergetics aspect of metabolism. There is a plethora of analytical biochemical methods to monitor metabolites
Externí odkaz:
https://doaj.org/article/2bad0a2883624dae8ae9d914857f9a2a
Autor:
Sofia K. Georgiou-Siafis, Martina K. Samiotaki, Vassilis J. Demopoulos, George Panayotou, Asterios S. Tsiftsoglou
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1959 (2022)
Hemin, an oxidized form of heme, acts as potent oxidant to regulate glutathione (GSH) content in pro-erythroid K562 nucleated cells, via activation of the KEAP1/NRF2 defensive signaling pathway. Moreover, GSH, as an essential metabolite, is involved
Externí odkaz:
https://doaj.org/article/ed316448150d4603a2fa23b813692c4a
Autor:
Vagelis Rinotas, Panagiotis Nikolaou, Konstantinos Kritikos, Apostolos Papadopoulos, Lenka Plestilova, Astrid Jüngel, Martina Samiotaki, George Panayotou, Eleni Douni
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100461- (2020)
Externí odkaz:
https://doaj.org/article/49f8f95d679945878f4ffcdf36e32e52