Zobrazeno 1 - 10
of 68
pro vyhledávání: '"George P.A. Rice"'
Autor:
J. Baskerville, Brian G. Weinshenker, George C. Ebers, George P.A. Rice, W. Carriere, John H. Noseworthy
Publikováno v:
Scopus-Elsevier
We used hypothetical entry criteria typical of those used in clinical therapeutic trials to determine the patients who would have been eligible among those followed in a clinic-based study of multiple sclerosis (MS) in London, Ontario, between 1972 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679674fd70980918381d1ffc9299002b
https://doi.org/10.1093/brain/114.2.1057
https://doi.org/10.1093/brain/114.2.1057
Autor:
Margaret K. Vandervoort, K. D. Grinwich, Donald H. Lee, H. Cauvier, B. J. Harris, S. J. Karlik, George P.A. Rice, Marybeth Hopkins, M. Penman, George C. Ebers, J. H. Noseworthy
We treated 13 patients with progressive MS with mitoxantrone. All patients received a standard IV dose of mitoxantrone (8 mg/m2) every 3 weeks for a total of seven infusions, with dosage adjustments depending on the hematologic profile at the nadir.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900c88cf87d15ad15e1378bfe50abba8
https://doi.org/10.1212/wnl.43.7.1401
https://doi.org/10.1212/wnl.43.7.1401
The clinical features of relapses and progression largely define multiple sclerosis phenotypes. A relapsing course is followed by chronic progression in some 80% of cases within 2 decades. The relationship between these phases and long-term outcome r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fe774971079071dfb2f63b0146c20c
https://ora.ox.ac.uk/objects/uuid:00a83820-b5e7-4b1f-9ecc-d767e4cf140c
https://ora.ox.ac.uk/objects/uuid:00a83820-b5e7-4b1f-9ecc-d767e4cf140c
Autor:
Alexandra Degenhardt, Anneke Neuhaus, Antonio Scalfari, Paolo A. Muraro, Martin Daumer, George C. Ebers, George P.A. Rice
Publikováno v:
Brain
The relationship of relapses to long-term disability in multiple sclerosis is uncertain. Relapse reduction is a common therapeutic target but clinical trials have shown dissociation between relapse suppression and disability accumulation. We investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e67e28000d40bc7f06ba6d3fc2c50e
https://doi.org/10.1093/brain/awq118
https://doi.org/10.1093/brain/awq118
Publikováno v:
Neurology. 64:1336-1342
The symptoms, severity, and course of multiple sclerosis (MS) vary among patients, leading to complex treatment issues. In recent years, research has focused on specific adhesion molecules that participate in the activation and function of lymphocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b89a1ec936cb3f4cef2af1f6bc1b93b
https://doi.org/10.1212/01.wnl.0000158329.30470.d0
https://doi.org/10.1212/01.wnl.0000158329.30470.d0
Autor:
George C. Ebers, M. Kremenchutzky, Walter Hader, W. J. Koopman, D. A. Cottrell, J. Baskerville, George P.A. Rice
Publikováno v:
Brain. 122:625-639
Classifications of multiple sclerosis subtypes have been largely based on clinical phenomenology. Nevertheless, definitions of relapse, remission and progression have been imprecise. Recently an international consensus group, as part of a reclassific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e828ac19875d978727da6a35117dd917
https://doi.org/10.1093/brain/122.4.625
https://doi.org/10.1093/brain/122.4.625
Autor:
George P.A. Rice
Publikováno v:
BioDrugs. 12:267-277
Disease progression and advancing disability will supervene in the majority of multiple sclerosis patients who are followed over the long-term. This process can begin insidiously from the onset of the disease (primary progression) or after one or mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045f960bbb3379020e01bf992d3e2977
https://doi.org/10.2165/00063030-199912040-00004
https://doi.org/10.2165/00063030-199912040-00004
Autor:
K Cousin, S Hashimoto, J E Paulseth, A D Sadovnick, Jean-Pierre Bouchard, Pierre Duquette, George C. Ebers, Luanne M. Metz, T. Gray, K Kukay, William Pryse-Phillips, T J Murray, Avindra Nath, Sharon Warren, David A. Hinds, H. Armstrong, R. F. Nelson, Neil Risch, Carol M. Anderson, Joel Oger, George P.A. Rice, W Hader, Donald G. Brunet, Dennis E. Bulman, A. Auty, Robert B. Bell, Matthew L. Freedman, Paul O'Connor, Donald W. Paty, Gordon S. Francis
Publikováno v:
Nature Genetics. 13:472-476
The aetiology of multiple sclerosis (MS) is uncertain. There is strong circumstantial evidence to indicate it is an autoimmune complex trait. Risks for first degree relatives are increased some 20 fold over the general population. Twin studies have s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffbb67f82004f7a7b66c54a286cf768
https://doi.org/10.1038/ng0896-472
https://doi.org/10.1038/ng0896-472
Autor:
Stephen J. Karlik, Michael Eliasziw, J. Ross Mitchell, George P.A. Rice, Aaron Fenster, Donald H. Lee
Publikováno v:
Medical Physics. 23:115-126
Recently, guidelines for the use of MRI in the monitoring of MS have recommended the use of imaging systems with mid-field (0.5-1.0 T) or high-field (greater than 1.0 T) strengths. Higher field strengths provide many advantages, including increased s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cbddd053f40a283d2e495be20d0d01
https://doi.org/10.1118/1.597689
https://doi.org/10.1118/1.597689
Publikováno v:
Journal of Infectious Diseases. 170:1267-1271
To study fetal brain infection with human cytomegalovirus (HCMV), an in vitro model was established using the human primary nontransformed neuronal cell line HCN-1A. On exposure to a mixture of factors promoting differentiation, HCN-1A cells differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2336cae9cd2742f6850fdf1c6bd30455
https://doi.org/10.1093/infdis/170.5.1267
https://doi.org/10.1093/infdis/170.5.1267