Zobrazeno 1 - 10
of 38
pro vyhledávání: '"George P. Murphy"'
Autor:
Dmitry A. Kretov, Leighton Folkes, Alexandra Mora-Martin, Isha A. Walawalkar, Imrat, Noreen Syedah, Kim Vanuytsel, Simon Moxon, George J. Murphy, Daniel Cifuentes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post-transcriptional regulatory layer instructs the level of chromatin reg
Externí odkaz:
https://doaj.org/article/12c9809215524e7283c8840d491bb1be
Autor:
Alexandra B. Ysasi, Anna E. Engler, Pushpinder Singh Bawa, Feiya Wang, Regan D. Conrad, Anthony K. Yeung, Jason R. Rock, Jennifer Beane-Ebel, Sarah A. Mazzilli, Ruth A. Franklin, Joseph P. Mizgerd, George J. Murphy
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110169- (2024)
Summary: Macrophages are critical for maintenance and repair of mucosal tissues. While functionally distinct subtypes of macrophage are known to have important roles in injury response and repair in the lungs, little is known about macrophages in the
Externí odkaz:
https://doaj.org/article/5b903bda8cf440d19e820e282f3de643
Autor:
Marcell Costa de Medeiros, Stephanie The, Emily Bellile, Nickole Russo, Ligia Schmitd, Erika Danella, Priyanka Singh, Rajat Banerjee, Christine Bassis, George R. Murphy, Maureen A. Sartor, Isabelle Lombaert, Thomas M. Schmidt, Avi Eisbruch, Carol Anne Murdoch-Kinch, Laura Rozek, Gregory T. Wolf, Gen Li, Grace Y. Chen, Nisha J. D’Silva
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-23 (2023)
Abstract Background Oral squamous cell carcinoma (SCC) is associated with oral microbial dysbiosis. In this unique study, we compared pre- to post-treatment salivary microbiome in patients with SCC by 16S rRNA gene sequencing and examined how microbi
Externí odkaz:
https://doaj.org/article/53d09eb53b624a0d8219879a7a9c03cf
Autor:
Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Jünger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schröder, Samar Sadeghi, Seda Ballikaya, Martin Gasser, Ana M. Waaga-Gasser, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-25 (2022)
Abstract Background While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly to standard treatment. GMP-manufactured skin-derived ABCB5+ mese
Externí odkaz:
https://doaj.org/article/4819e8d8b5ba4b6b811f719469da6383
Autor:
Leonard Knoedler, Samuel Knoedler, Adriana C. Panayi, Catherine A. A. Lee, Sam Sadigh, Lioba Huelsboemer, Viola A. Stoegner, Andreas Schroeter, Barbara Kern, Vikram Mookerjee, Christine G. Lian, Stefan G. Tullius, George F. Murphy, Bohdan Pomahac, Martin Kauke-Navarro
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive surgery that has revolutionized the treatment of patients with devastating injuries, including those with limb losses or facial disfigurement. The transplanted un
Externí odkaz:
https://doaj.org/article/ed8a16d5bc9b49b6ae63569214747c5c
Autor:
Wei Wen Teo, Xinang Cao, Chan-Shuo Wu, Hong Kee Tan, Qiling Zhou, Chong Gao, Kim Vanuytsel, Sara S. Kumar, George J. Murphy, Henry Yang, Li Chai, Daniel G. Tenen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Identification of a long non-coding RNA LEVER, that inhibits the Polycomb Repressive Complex 2 (PRC2) and controls nearby embryonic form of beta-globin gene, provides additional evidence for PRC2-RNA functional interaction.
Externí odkaz:
https://doaj.org/article/c0033e53f61b43739e86a5b844cef74f
Autor:
Kim Vanuytsel, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Zhe Wang, Wilfredo F. Garcia-Beltran, Vladimir Vrbanac, Dylan Parsons, Evan C. Lam, Taylor M. Matte, Todd W. Dowrey, Sara S. Kumar, Mengze Li, Feiya Wang, Anthony K. Yeung, Gustavo Mostoslavsky, Ruben Dries, Joshua D. Campbell, Anna C. Belkina, Alejandro B. Balazs, George J. Murphy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
During human embryonic development, haematopoietic stem cells of the foetal liver undergo expansion, while retaining engraftment capacity. Here the authors apply CITE-seq to profile single cells from a human foetal liver, identifying a molecular sign
Externí odkaz:
https://doaj.org/article/cac11a57fa10405ca22f6fddb6df2365
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 8 (2022)
Spitz neoplasms are a diverse group of molecularly and histologically defined melanocytic tumors with varying biologic potentials. The precise classification of Spitz neoplasms can be challenging. Recent studies have revealed recurrent fusions involv
Externí odkaz:
https://doaj.org/article/dc462cf7d3294525bc57d2e3baa86590
Autor:
Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Ann-Kathrin Dachtler, Korinna Kraft, Markus Stücker, Georg Daeschlein, Michael Jünger, Tobias Görge, Ulrich Meyer-Pannwitt, Cornelia Erfurt-Berge, Charlotte von Engelhardt, Andreas Klare, Christiane Pfeiffer, Jasmina Esterlechner, Hannes M. Schröder, Martin Gasser, Ana M. Waaga-Gasser, Matthias Goebeler, Seda Ballikaya, Samar Sadeghi, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth
Publikováno v:
JID Innovations, Vol 2, Iss 1, Pp 100067- (2022)
A significant number of chronic venous ulcers (CVUs) fail to heal despite guideline-conform standards of care. Skin-derived ABCB5+ mesenchymal stem cells can dampen the sustained IL-1β‒driven inflammation present in chronic wounds. On the basis of
Externí odkaz:
https://doaj.org/article/30269062a0c04e579251c083a6768869
Autor:
Mengfan Wu, Dany Y. Matar, Zhen Yu, Ziyu Chen, Samuel Knoedler, Brian Ng, Oliver A. Darwish, Sadaf Sohrabi, Leigh Friedman, Valentin Haug, George F. Murphy, Yuval Rinkevich, Dennis P. Orgill, Adriana C. Panayi
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2125 (2022)
Scarring is associated with significant morbidity. The mechanical signaling factor yes-associated protein (YAP) has been linked to Engrailed-1 (En1)-lineage positive fibroblasts (EPFs), a pro-scarring fibroblast lineage, establishing a connection bet
Externí odkaz:
https://doaj.org/article/6c3ad043fe484fbc8ec105a129948200