Zobrazeno 1 - 10
of 43
pro vyhledávání: '"George P. Liao"'
Autor:
Supinder S. Bedi, Benjamin M. Aertker, George P. Liao, Henry W. Caplan, Deepa Bhattarai, Fanni Mandy, Franciska Mandy, Luis G. Fernandez, Pamela Zelnick, Matthew B. Mitchell, Walter Schiffer, Margaret Johnson, Emma Denson, Karthik Prabhakara, Hasen Xue, Philippa Smith, Karen Uray, Scott D. Olson, Robert W. Mays, Charles S. Cox
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-13 (2018)
Abstract Background Traumatic brain injury (TBI) is a major cause of death and disability. TBI results in a prolonged secondary central neuro-inflammatory response. Previously, we have demonstrated that multiple doses (2 and 24 h after TBI) of multip
Externí odkaz:
https://doaj.org/article/cce291713bdd42509e6bebc93fc98d84
Autor:
George P. Liao, Benjamin M. Aertker, Daniel J. Kota, Karthik S. Prabhakara, Philipp Smith, Robert A. Hetz, Hasen Xue, Supinder Bedi, Scott D. Olson, Charles S. Cox
Publikováno v:
ADMET and DMPK, Vol 3, Iss 3, Pp 182-189 (2015)
The blood brain barrier plays an important role in traumatic brain injury, serving at the crossroads of secondary injury and potential therapies. In regards to trauma, this barrier contains an array of cellular and molecular components that protect t
Externí odkaz:
https://doaj.org/article/b8bb097843cf4017ad11c3a8874f2bf8
Autor:
Yue-Ming Li, Naga Vara Kishore Pillarsetty, Jason S. Lewis, Lukas M. Carter, Blesida Punzalan, Kelly E. Henry, Georgia Frost, George P. Liao, Thomas Li, Xianzhong Wu, Veronica L. Nagle, Teja Kalidindi, Pengju Nie
Purpose:Abnormal Notch signaling promotes cancer cell growth and tumor progression in various cancers. Targeting γ-secretase, a pivotal regulator in the Notch pathway, has yielded numerous γ-secretase inhibitors (GSIs) for clinical investigation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7fa567cdfaa98b337a9a25705f95ce
https://doi.org/10.1158/1078-0432.c.6530742.v1
https://doi.org/10.1158/1078-0432.c.6530742.v1
Autor:
Yue-Ming Li, Naga Vara Kishore Pillarsetty, Jason S. Lewis, Lukas M. Carter, Blesida Punzalan, Kelly E. Henry, Georgia Frost, George P. Liao, Thomas Li, Xianzhong Wu, Veronica L. Nagle, Teja Kalidindi, Pengju Nie
Supplementary Figure 1. The radiolabeling product of [124I]PN67 was confirmed by co-injecting cold compound 2 (100uM in 100ul DMSO/H2O/MeCN) with the radioactive fraction (50uCi in 100ul H2O/MeCN) onto HPLC. (A) UV 235/254nm wavelength channels were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7830870d737367f074916de621b096
https://doi.org/10.1158/1078-0432.22481619.v1
https://doi.org/10.1158/1078-0432.22481619.v1
Autor:
Yue-Ming Li, Naga Vara Kishore Pillarsetty, Jason S. Lewis, Lukas M. Carter, Blesida Punzalan, Kelly E. Henry, Georgia Frost, George P. Liao, Thomas Li, Xianzhong Wu, Veronica L. Nagle, Teja Kalidindi, Pengju Nie
Supplementary Table 1. Biodistribution data of [124I]PN67 versus time/h, administrated by i.v. tail-vein injection in BALB/c mice bearing 4T1-Luc tumors. Data is represented as average %ID/g {plus minus} SD with n=5 animals/group.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e2e62712a85cfc12139c8cce5accde
https://doi.org/10.1158/1078-0432.22481601.v1
https://doi.org/10.1158/1078-0432.22481601.v1
Autor:
Yue-Ming Li, Naga Vara Kishore Pillarsetty, Jason S. Lewis, Lukas M. Carter, Blesida Punzalan, Kelly E. Henry, Georgia Frost, George P. Liao, Thomas Li, Xianzhong Wu, Veronica L. Nagle, Teja Kalidindi, Pengju Nie
NMR and Mass (HRMS) spectroscopy data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae91e51864771731efc88e1ce8d3718
https://doi.org/10.1158/1078-0432.22481604
https://doi.org/10.1158/1078-0432.22481604
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance γ-Secretase cleaves multiple transmembrane proteins, but little is known about how it controls its substrate specificity. γ-Secretase activating protein (GSAP) has been reported to differentially activate γ-secretase for APP and Notch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4386df35ae555b376b0dff25062183
https://doi.org/10.1073/pnas.1820160116
https://doi.org/10.1073/pnas.1820160116
Autor:
George P. Liao, Thomas Li, Kelly E. Henry, Veronica L. Nagle, Blesida Punzalan, Xianzhong Wu, Jason S. Lewis, Lukas M. Carter, Naga Vara Kishore Pillarsetty, Pengju Nie, Teja Kalidindi, Georgia R. Frost, Yue-Ming Li
Publikováno v:
Clin Cancer Res
Purpose: Abnormal Notch signaling promotes cancer cell growth and tumor progression in various cancers. Targeting γ-secretase, a pivotal regulator in the Notch pathway, has yielded numerous γ-secretase inhibitors (GSIs) for clinical investigation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd8701089a39acff7d3d4e980642e68
https://pubmed.ncbi.nlm.nih.gov/34475100
https://pubmed.ncbi.nlm.nih.gov/34475100
Autor:
George P. Liao, Jenifer Juranek, Claudia Pedroza, Anna Romanowska-Pawliczek, Pramod K. Dash, Huimahn A Choi, Robert A. Hetz, Laura L. Worth, Benjamin M. Aertker, Imoigele P. Aisiku, Margaret L. Jackson, Linda Ewing-Cobbs, Sean I Savitz, Dean A. Lee, John B. Holcomb, Fabio Triolo, Ryan S. Kitagawa, Charles S. Cox
Publikováno v:
Stem Cells. 35:1065-1079
Preclinical studies using bone marrow derived cells to treat traumatic brain injury have demonstrated efficacy in terms of blood–brain barrier preservation, neurogenesis, and functional outcomes. Phase 1 clinical trials using bone marrow mononuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf8ee498648dd6f17709e56fcb3a638
https://doi.org/10.1002/stem.2538
https://doi.org/10.1002/stem.2538
Autor:
Benjamin M. Aertker, George P. Liao, Robert W. Mays, Fanni Mandy, Supinder S. Bedi, Margaret Johnson, Emma Denson, Matthew B. Mitchell, Scott D. Olson, Hasen Xue, Luis G. Fernandez, Philippa Smith, Franciska Mandy, Karthik S. Prabhakara, Henry W. Caplan, Charles S. Cox, Karen S. Uray, Walter Schiffer, Deepa Bhattarai, Pamela Zelnick
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-13 (2018)
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-13 (2018)
Background Traumatic brain injury (TBI) is a major cause of death and disability. TBI results in a prolonged secondary central neuro-inflammatory response. Previously, we have demonstrated that multiple doses (2 and 24 h after TBI) of multipotent adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5b33ad1cfa9c7ce78f665a4eea19a0
http://europepmc.org/articles/PMC5856201
http://europepmc.org/articles/PMC5856201