Zobrazeno 1 - 10
of 123
pro vyhledávání: '"George P Vlasuk"'
Autor:
James G Krueger, Mayte Suárez-Fariñas, Inna Cueto, Artemis Khacherian, Robert Matheson, Lawrence C Parish, Craig Leonardi, Denise Shortino, Akanksha Gupta, Jonathan Haddad, George P Vlasuk, Eric W Jacobson
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142081 (2015)
Activation of Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, is an unexplored therapeutic approach for treatment of inflammatory diseases. We randomized 40 patients with moderate-to-severe psoriasis (4:1) to three escalati
Externí odkaz:
https://doaj.org/article/9e19d739bed14e038b7414b6243efab0
Autor:
Hongying Yang, Wei Zhang, Heng Pan, Heidi G Feldser, Elden Lainez, Christine Miller, Stewart Leung, Zhong Zhong, Huizhen Zhao, Sharon Sweitzer, Thomas Considine, Thomas Riera, Vipin Suri, Brian White, James L Ellis, George P Vlasuk, Christine Loh
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46364 (2012)
Chronic inflammation is a major contributing factor in the pathogenesis of many age-associated diseases. One central protein that regulates inflammation is NF-κB, the activity of which is modulated by post-translational modifications as well as by a
Externí odkaz:
https://doaj.org/article/a56d628fd5a94f1da31e23a4f38bf9f6
Autor:
Vincenzo Libri, Andrew P Brown, Giulio Gambarota, Jonathan Haddad, Gregory S Shields, Helen Dawes, David J Pinato, Ethan Hoffman, Peter J Elliot, George P Vlasuk, Eric Jacobson, Martin R Wilkins, Paul M Matthews
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51395 (2012)
SRT2104 has been developed as a selective small molecule activator of SIRT1, a NAD(+)-dependent deacetylase involved in the regulation of energy homeostasis and the modulation of various metabolic pathways, including glucose metabolism, oxidative str
Externí odkaz:
https://doaj.org/article/45457f0e83024b468534bb0f4103a851
Autor:
Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk, Eddine Saiah
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Aberrant mTORC1 signaling is linked to several chronic diseases. Here, the authors develop a small molecule inhibitor that binds the small G-protein Rheb and selectively blocks mTORC1 signaling, holding potential for therapeutic applications.
Externí odkaz:
https://doaj.org/article/e4e93d6c676242c793f6e0e9b9280186
Autor:
Elaine M. Quinet, Michael D. Basso, Anita R. Halpern, David W. Yates, Robert J. Steffan, Valerie Clerin, Christine Resmini, James C. Keith, Thomas J. Berrodin, Irene Feingold, Wenyan Zhong, Helen B. Hartman, Mark J. Evans, Stephen J. Gardell, Elizabeth DiBlasio-Smith, William M. Mounts, Edward R. LaVallie, Jay Wrobel, Ponnal Nambi, George P. Vlasuk
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 12, Pp 2358-2370 (2009)
Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in several cellular functions but most notably cholesterol homeostasis encompassing cholesterol transport, catabolism, and abso
Externí odkaz:
https://doaj.org/article/ec0b71a6e2bf4790a3a5a3256e00f5d7
Autor:
Catharine H. Duman, George P. Vlasuk, Taro Kato, Santosh Pothula, Rong-Jian Liu, Eddine Saiah, Seung Hahm, Ronald S. Duman, Rosemarie Terwilliger
Publikováno v:
J Clin Invest
Preclinical studies demonstrate that rapid-acting antidepressants, including ketamine, require stimulation of mTORC1 signaling. This pathway is regulated by neuronal activity and endocrine and metabolic signals, notably including the amino acid leuci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bc335f8b180901f671e2f0efb2f1c7
https://europepmc.org/articles/PMC6546461/
https://europepmc.org/articles/PMC6546461/
Autor:
Emilie Giaime, George P. Vlasuk, Jessica J. Howell, Shomit Sengupta, Seung Hahm, David John O'neill, Eddine Saiah, Sridhar Narayan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several important chronic medical conditions many of which are associated with advancing age. A variety of inputs including the amino acid leucine are required for full mTORC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6678722f6226c83bc4a70778e2d4d3
https://doi.org/10.1038/s41598-019-40693-5
https://doi.org/10.1038/s41598-019-40693-5
Autor:
Robert Langer, John M. Maraganore, David P. Schenkein, Neil Warma, Chris Adams, Chip Clark, Mark Levin, William Rastetter, Bruce A Leicher, Nancy A Thornberry, Robert I Blum, Jonathan G Rosin, Kleanthis G Xanthopoulos, Timothy D. Harris, Jeff L Cleland, Robert Forrester, Nancy Simonian, Peter Barrett, Stephen Bloch, William J Rieflin, Brian M Gallagher, Lewis Rusty Williams, Doug Doerfler, Richard Ulevitch, David R. Liu, Andrew Levin, P. Grint, Nick J Simon, Pablo J Cagnoni, Daphne Zohar, Kush M Parmar, Guy Macdonald, Corey M McCann, Stelios Papadopoulos, Michael D Clayman, Diego Miralles, Paula Cobb, John Diekman, Jeremy M Levin, Amir Nashat, Samuel G Waksal, Rachel King, Sandford Sandy Zweifach, Gail J Maderis, Ankit Mahadevia, Heather Franklin, Cary G Pfeffer, Steven K Brauer, Akshay Vaishnaw, Clay B. Siegall, Howard Furst, Jonathan S Leff, William J Rutter, Dennis J. Purcell, Mary T Szela, J C Gutierrez-Ramos, Sean A McCarthy, Elizabeth Lr Donley, Yaron Werber, Doug E Williams, Christoph Westphal, Paul Sekhri, W Eddie Martucci, Jeb Keiper, John E Osborn, Simba Gill, Bassil Dahiyat, Steven H Holtzman, Annalisa Jenkins, Saurabh Saha, Matthew J. During, Camille Samuels, Mara G Aspinall, Chad Robins, Jason P Rhodes, Herve Hoppenot, Jeff Kaplan, Michael A Narachi, Amit Rakhit, Julia C Owens, Steve M Paul, Martin Varsavsky, Mark G. Currie, Rajeev Shah, Rob Perez, H. Stewart Parker, Jeff Stein, Leonard Patrick Gage, Perry Karsen, Joel F Martin, Bob More, Matthew Perry, James G McArthur, Gregory J Flesher, Martin Tolar, Andrew Schwab, James A Geraghty, Eric L Dobmeier, Brook Byers, Vanessa King, Mason W. Freeman, Larry Miller, Marco Taglietti, Jeff Albers, Neil A Exter, Michael W Bonney, Ron Cohen, Nick Leschly, Bruce L Booth, William J Newell, Peter Kolchinsky, Ryan J Watts, Paul Laikind, Andrew G. Myers, Cedric Francois, Stephen T Isaacs, Scott Koenig, Michel Vounatsos, Tuan Ha-Ngoc, Nicholas Galakatos, George P Vlasuk, Isaac Ciechanover, Jeff Kindler, Brian M. Cali, Matthew R Patterson, Kenneth I Moch, Tom Graney, Martin Babler, Jonathan J Fleming, Mark A Goldsmith, Daniel M Bradbury, John Mendlein, Mike Powell, Nessan Bermingham, Eric Elenko, H. Robert Horvitz, Yujiro Steve Hata, Mark Pruzanski, Faheem Hasnain, Henri A. Termeer, Maxine Gowen, Scott M Rocklage, Anne VanLent, Thomas Shenk, Leslie Henshaw, Jeff Jonker, Nina Kjellson, Deborah Dunsire, Zoe Barry, Ron C Renaud, Alex Martin, Uri Lopatin, George Scangos, Jean Kim, Kartik Ramamoorthi, Michael Rosenblatt, Nagesh K Mahanthappa, Harvey F. Lodish, Paul B Bolno, Wendell Wierenga, Atul Pande, Barry Greene, Alan Levy, Adrian Ad Rawcliffe, Wende S Hutton, C Geoffrey McDonough, Vicki L. Sato, Jean-Francois Formela, David V. Goeddel, Bill Haney, Rich Heyman, James E Audia, Ron Cooper, Nina Tandon, Brett Ahrens, Julian Adams, Peter Hecht, John J Lee, Stuart L. Schreiber, Laurence E Reid, Bernat Olle, Paul Hastings, John A. Scarlett, Michael Su, David Grayzel, Ted W Love, Arnold J. Levine, Gerhard Koenig, Thomas E Hughes, Jens W Eckstein, Wendy Nelson, Vikas Goyal
Publikováno v:
Nature Biotechnology. 35:204-206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2d10770c0eb9d17bb770366663a693
https://doi.org/10.1038/nbt.3824
https://doi.org/10.1038/nbt.3824
Autor:
Lauren A. Berstler, Sarah J. Mahoney, George P. Vlasuk, Sridhar Narayan, Eddine Saiah, Seong A. Kang, Lisa Molz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
The small G-protein Rheb activates the mechanistic target of rapamycin complex 1 (mTORC1) in response to growth factor signals. mTORC1 is a master regulator of cellular growth and metabolism; aberrant mTORC1 signaling is associated with fibrotic, met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79821839bb734d9a67167aa43008928e
https://doi.org/10.1038/s41467-018-03035-z
https://doi.org/10.1038/s41467-018-03035-z
Autor:
Oleg Kraydashenko, George P. Vlasuk, Peter J. Elliott, Arun K. Baksi, Ethan Hoffmann, Eric W. Jacobson, Jonathan Haddad, Alsu Zalevkaya, Roman Stets
Publikováno v:
British Journal of Clinical Pharmacology. 78:69-77
Aim SRT2104 is a selective activator of SIRT1. In animal models, SRT2104 improves glucose homeostasis and increases insulin sensitivity. We evaluated the tolerability and pharmacokinetics of SRT2104, and its effects on glycaemic control, in adults wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50926de29542c7ba78e50d0f5a40efb2
https://doi.org/10.1111/bcp.12327
https://doi.org/10.1111/bcp.12327