Zobrazeno 1 - 10
of 52
pro vyhledávání: '"George P, Dinos"'
Autor:
Georgia G. Kournoutou, Panagiota C. Giannopoulou, Eleni Sazakli, Michalis Leotsinidis, Dimitrios L. Kalpaxis, George P. Dinos
Publikováno v:
Toxics, Vol 8, Iss 4, p 89 (2020)
The impact of metals bioaccumulation in marine organisms is a subject of intense investigation. This study was designed to determine the association between oxidative stress induced by seawater enriched with trace metals and protein synthesis using a
Externí odkaz:
https://doaj.org/article/6ab6a85c199a4ae7af6785a36b1ea7e5
Autor:
Panagiota C. Giannopoulou, Dionissia A. Missiri, Georgia G. Kournoutou, Eleni Sazakli, Georgios E. Papadopoulos, Dionissios Papaioannou, George P. Dinos, Constantinos M. Athanassopoulos, Dimitrios L. Kalpaxis
Publikováno v:
Antibiotics, Vol 8, Iss 1, p 9 (2019)
Over the last years, we have been focused on chloramphenicol conjugates that combine in their structure chloramphenicol base with natural polyamines, spermine, spermidine and putrescine, and their modifications. Conjugate 3, with spermidine (SPD) as
Externí odkaz:
https://doaj.org/article/0310811461524476b92200062bb1396d
Autor:
Ourania N Kostopoulou, George E Magoulas, Georgios E Papadopoulos, Athanasia Mouzaki, George P Dinos, Dionissios Papaioannou, Dimitrios L Kalpaxis
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134526 (2015)
As fight against antibiotic resistance must be strengthened, improving old drugs that have fallen in reduced clinical use because of toxic side effects and/or frequently reported resistance, like chloramphenicol (CAM), is of special interest. Chloram
Externí odkaz:
https://doaj.org/article/0ca8fb61f603433ea8dc1089a63d44b3
Autor:
Elena Plessa, Anthony Bougas, Yury S. Polikanov, George P. Dinos, Maxim S. Svetlov, Marios G. Krokidis, Chih-Wei Chen
Publikováno v:
RNA
The 70S ribosome is a major target for antibacterial drugs. Two of the classical antibiotics, chloramphenicol (CHL) and erythromycin (ERY), competitively bind to adjacent but separate sites on the bacterial ribosome: the catalytic peptidyl transferas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f44e88d726cfd1c1188d9d018bade0
https://doi.org/10.1261/rna.069260.118
https://doi.org/10.1261/rna.069260.118
Autor:
Constantinos M. Athanassopoulos, George P. Dinos, Georgia G. Kournoutou, Eleni Poulou-Sidiropoulou, Artemis Tsirogianni, Anthony Bougas
Publikováno v:
Antibiotics, Vol 10, Iss 394, p 394 (2021)
Antibiotics
Volume 10
Issue 4
Antibiotics
Volume 10
Issue 4
To combat the dangerously increasing pathogenic resistance to antibiotics, we developed new pharmacophores by chemically modifying a known antibiotic, which remains to this day the most familiar and productive way for novel antibiotic development. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026fa084aaae29576fd42107441d220a
https://www.mdpi.com/2079-6382/10/4/394
https://www.mdpi.com/2079-6382/10/4/394
Autor:
George P. Dinos, Constantinos M. Athanassopoulos, Dionissia A. Missiri, Panagiota C. Giannopoulou, Ioannis A. Vlachogiannis, Georgios E. Papadopoulos, Dionissios Papaioannou, Dimitrios L. Kalpaxis
Publikováno v:
Antibiotics, Vol 5, Iss 2, p 20 (2016)
Chloramphenicol (CAM) is the D-threo isomer of a small molecule, consisting of a p-nitrobenzene ring connected to a dichloroacetyl tail through a 2-amino-1,3-propanediol moiety. CAM displays a broad-spectrum bacteriostatic activity by specifically in
Externí odkaz:
https://doaj.org/article/1c026c2eed274faab59cd55f2b6975d2
Autor:
Dimitrios L. Kalpaxis, Panagiota C. Giannopoulou, Georgia G Kournouto, Eleni Sazakli, George P. Dinos, Michalis Leotsinidis
Publikováno v:
Toxics, Vol 8, Iss 89, p 89 (2020)
Toxics
Volume 8
Issue 4
Toxics
Volume 8
Issue 4
The impact of metals bioaccumulation in marine organisms is a subject of intense investigation. This study was designed to determine the association between oxidative stress induced by seawater enriched with trace metals and protein synthesis using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee474c72c426eff6386d7c5d220ee9d0
https://doi.org/10.20944/preprints202009.0642.v1
https://doi.org/10.20944/preprints202009.0642.v1
Autor:
George P. Dinos
Publikováno v:
British Journal of Pharmacology. 174:2967-2983
Macrolides represent a large family of protein synthesis inhibitors of great clinical interest due to their applicability to human medicine. Macrolides are composed of a macrocyclic lactone of different ring sizes, to which one or more deoxy-sugar or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b6a77dfeb362d22522fcef9e9e9eee
https://doi.org/10.1111/bph.13936
https://doi.org/10.1111/bph.13936
Publikováno v:
Amino Acids. 49:995-1004
Chloramphenicol peptides were recently established as useful tools for probing nascent polypeptide chain interaction with the ribosome, either biochemically, or structurally. Here, we present a new 10mer chloramphenicol peptide, which exerts a dual i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8a23f4e9b787252de26197518d92cf
https://doi.org/10.1007/s00726-017-2406-5
https://doi.org/10.1007/s00726-017-2406-5
Autor:
Yury S. Polikanov, Thomas A. Steitz, Benjamin J. Burnett, Scott C. Blanchard, Agata L. Starosta, George P. Dinos, Wanli Lu, Daniel S. Terry, Daniel N. Wilson, Roger B. Altman, Manuel F. Juette, Kevin A. Reynolds
Publikováno v:
Molecular Cell. 58:832-844
The increase in multi-drug resistant bacteria is limiting the effectiveness of currently approved antibiotics, leading to a renewed interest in antibiotics with distinct chemical scaffolds. We have solved the structures of the Thermus thermophilus 70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1867bfaba49c19132aa2c0dc1a431a
https://doi.org/10.1016/j.molcel.2015.04.014
https://doi.org/10.1016/j.molcel.2015.04.014